A5054679667- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- T-cell and Retrovirus Studies
- HIV/AIDS drug development and treatment
- RNA regulation and disease
- Diabetes Treatment and Management
- Hemoglobinopathies and Related Disorders
- Hemoglobin structure and function
- Virus-based gene therapy research
- Machine Learning in Bioinformatics
- Cytomegalovirus and herpesvirus research
- 14-3-3 protein interactions
- Erythrocyte Function and Pathophysiology
- Viral Infectious Diseases and Gene Expression in Insects
- Genomics and Chromatin Dynamics
- Glycosylation and Glycoproteins Research
Yokohama City University
2018
Kyoto University
2010-2017
Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs subsequent translational regulation. Msi1 has two RNA-binding domains (RBDs), RBD1 RBD2, which recognize r(GUAG) r(UAG), respectively. These minimal recognition sequences are connected by variable linkers in mRNAs, however, molecular mechanism recognizes targets is not yet understood. We previously determined solution structure RBD1:r(GUAGU) complex. Here, we first RBD2:r(GUAGU) The...
Acetyl-3,5-dibromosalicylic acid (dibromoaspirin) is shown to be a potent acylating agent of intracellular hemoglobin in vitro. Transfer the actyl group dibromoaspirin amino groups hemoglobins A and S seems occur predominantly at just two or three sites on these proteins. This acetylation produces moderate increases oxygen affinities normal sickle erythrocytes. Furthermore, treatment with directly inhibits erythrocyte sickling. antisickling effect paralleled by an increase minimum gelling...
Micro RNA s are small noncoding that regulate translation and mRNA stability by binding target in complex with Argonaute ( AGO ) proteins. interacts a member of the TNRC 6 family proteins to form micro RNP complex, which recruits CCR 4‐ NOT accelerate deadenylation inhibits translation. primarily repress but have been shown enhance specific type reporter various experimental systems: G0 quiescent mammalian cells, Xenopus laevis oocytes, Drosophila embryo extracts, HeLa cells. In all cases...
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