A5042822966- Trypanosoma species research and implications
- Peroxisome Proliferator-Activated Receptors
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Viral Infections and Immunology Research
- Lipid metabolism and disorders
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- interferon and immune responses
- Parasites and Host Interactions
- Herpesvirus Infections and Treatments
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Tuberculosis Research and Epidemiology
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- Immune Response and Inflammation
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Fibrosis and Remodeling
Instituto de Investigaciones Biomédicas en Retrovirus y Sida
2018-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
University of Buenos Aires
2016-2024
Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied mechanisms involved latter, demonstrating participation of IL-10/STAT3/SOCS3 pathway. To achieve goal, properties were using an vitro model cardiomyocyte primary culture stimulated with LPS. LPS increased both SOCS3 expression and STAT3 phosphorylation. The...
Chagas disease, caused by Trypanosoma cruzi, is the main cause of dilated cardiomyopathy in Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) due to Nifurtimox shortage or unavailability. Both induce adverse drug effects (ADE) varied severity many patients, leading discontinuation abandonment. Since dosage may influence ADE, we aimed assess Bzl efficacy terms parasiticidal and anti-inflammatory activity, using doses lower than those previously reported. BALB/c mice...
Tuberculosis (TB) is a major health problem characterized by an immuno-endocrine imbalance: elevated plasma levels of cortisol and pro- anti-inflammatory mediators, as well reduced dehydroepiandrosterone. The etiological agent, Mycobacterium tuberculosis (Mtb), captured pulmonary macrophages (Mf), whose activation necessary to cope with the control Mtb, however, excessive inflammatory response also leads tissue damage. Glucocorticoids (GC) are critical elements counteract immunoinflammatory...
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from beginning of infection, is critical for control parasite proliferation and evolution Chagas disease. Peroxisome proliferator-activated receptors (PPAR)-α, are known to modulate inflammation. In this study we investigated whether a PPAR-α agonist, Fenofibrate, improves function parameters in murine model T. BALB/c mice were sequentially infected with two strains...
Chagas disease is caused by Trypanosoma cruzi infection and represents an important public health concern in Latin America. Macrophages are one of the main infiltrating leukocytes response to infection. Parasite persistence could trigger a sustained activation these cells, contributing damage observed this pathology, particularly heart. HP24, pyridinecarboxylic acid derivative, new PPARγ ligand that exerts anti-inflammatory pro-angiogenic effects. The aim work was deepen study mechanisms...
IL-10 is an anti-inflammatory cytokine that plays a significant role in the modulation of immune response many pathological conditions, including infectious diseases. Infection with Trypanosoma cruzi (T. cruzi), etiological agent Chagas disease, results ongoing inflammatory may cause heart dysfunction, ultimately leading to failure. Given its and nature, this work we analyzed whether lack hinders effects fenofibrate, PPARα ligand, murine model disease (CHD) using knockout (IL-10 KO) mice....
Chagas disease, caused by Trypanosoma cruzi, stands as the primary cause of dilated cardiomyopathy in Americas. Macrophages play a crucial role heart's response to infection. Given their functional and phenotypic adaptability, manipulating specific macrophage subsets could be vital aiding essential cardiovascular functions including tissue repair defense against PPARα are ligand-dependent transcription factors involved lipid metabolism inflammation regulation. However, fenofibrate, ligand,...
Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune and the microvascular abnormalities associated with are crucial aspects generation of heart damage Chagas disease. Upon parasite uptake, macrophages, which involved clearance infection, increase mediators, leading to killing. exacerbation may lead tissue damage. PPARγ is a ligand-dependent nuclear transcription factor that exerts important anti-inflammatory effects improving endothelial...
Benznidazole (Bzl), the drug of choice in many countries for treatment Chagas disease, leads to parasite clearance early stages infection and contributes immunomodulation. In addition its parasiticidal effect, Bzl inhibits NF-κB pathway. this regard, we have previously described that occurs through IL-10/STAT3/SOCS3 PI3K pathway is involved regulation immune system by inhibiting STAT3. work, participation immunomodulatory effects cardiac cells, main targets was further studied. For that, use...
Abstract Lipoprotein lipase (LPL) and endothelial (EL) are involved in lipoprotein metabolism. In insulin‐resistance, their behavior is altered. Peroxisome proliferator‐activated receptors (PPAR) apoproteins (apo)CII CIII could be partly responsible for these alterations. To evaluate this response, we assessed Lpl Lipg expression, protein levels, enzyme activity adipose tissue (AT) heart an obesity model. Besides, the role of PPAR apoC. Male Wistar rats were fed with standard diet (Control,...
Chronic cardiomyopathy is one of the most relevant outcomes Chagas disease associated with parasite persistence and exacerbated inflammatory response. Fenofibrate, a third generation fibric acid derivative peroxisome proliferator-activated receptor-α ligand, involved in regulation However, participation macrophages this scenario has not been elucidated. Here we show, for first time, that play fundamental role fenofibrate-mediated modulation heart pro-inflammatory response fibrosis caused by...
Chronic Chagas disease cardiomyopathy (CCC) is the most important clinical manifestation of infection with Trypanosma cruzi ( T. ) due to its frequency and effects on morbidity mortality. Peripheral blood mononuclear cells (PBMC) infiltrate tissue differentiate into inflammatory macrophages. Advances in pathophysiology show that myeloid cell subpopulations contribute cardiac homeostasis, emerging as possible therapeutic targets. We previously demonstrated fenofibrate, PPARα agonist, controls...
Abstract Background Myocardial infarction (MI) is a dynamic process that leads to ventricular remodeling (VR) and largely heart failure (HF). Previous studies established Galectin-3 (Gal-3) highly increased in the infarct zone from beginning of MI also it prognostic marker HF. Purpose We aimed study effects genetic deletion Gal-3 on macrophage (MΦ) infiltration, cytokines expression, fibrosis MMP-2 activity as well VR function after mice. Methods Male C57BL/6J KO mice were subjected...