A5011923444- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Vagus Nerve Stimulation Research
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Workplace Violence and Bullying
- Adipose Tissue and Metabolism
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Signaling Pathways in Disease
- Innovations in Medical Education
- Renin-Angiotensin System Studies
University of Buenos Aires
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2023
Instituto Cardiovascular de Buenos Aires
2015-2020
Instituto de Fisiología Vegetal
2018
Instituto de Cardiología y Cirugía Cardiovascular
2017
Universidad de Las Tunas
2013
Universidad de Sonora
2013
Centro Científico Tecnológico - San Juan
2006
Hospital Italiano de Buenos Aires
2003
Favaloro Foundation
2003
This investigation was designed to determine the participation of vagus nerve and muscarinic receptors in remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, femoral artery dissected. After 30 min monitoring, hearts isolated subjected global no-flow ischaemia 180 reperfusion (non-rIPC group). The ventricular function evaluated, considering left developed pressure end-diastolic pressure. In rIPC group, three cycles hindlimb (5 min) min), same protocol as...
The effect of ischemic postconditioning (Postcon) in hypercholesterolemic animals is unknown. objectives were to determine if preconditioning (IPC) and Postcon reduce infarct size assess A1 receptors K+(ATP) channels are involved mechanisms. Isolated rabbit hearts perfused according the Langendorff technique subjected 30 minutes ischemia reperfusion (G1). In Group 2, IPC was performed (1 cycle 5 ischemia/reperfusion) before ischemia. 3 (G3), (2 cycles 30-second reperfusion/ischemia) after G3...
What is the central question of this study? Ischaemia-reperfusion peripheral tissues protects heart from subsequent myocardial ischaemia-reperfusion injury, a phenomenon referred to as remote ischaemic preconditioning (rIPC). This study evaluated possible triggers rIPC. main finding and its importance? Remote reduces infarct size through vagal pathway mechanism involving phosphorylation Akt endothelial nitric oxide synthase, opening mitochondrial ATP-dependent K(+) channels an increase in H2...
The activation of matrix metalloproteinases (MMPs) contributes to myocardial injury at the onset reperfusion; however, their role in ischaemic postconditioning is unknown. aim present study was examine effects on MMP activity isolated rabbit hearts. hearts were subjected 30 min global ischaemia followed by 180 reperfusion (I/R group; n = 8). In group (n 8), a protocol performed (2 cycles s reperfusion-ischaemia). other experiments, we added doxycycline, an inhibitor, 25 7) or 50 micromol...
There is evidence that statin treatment before ischemia protects myocardium from ischemia/reperfusion injury. The objective to determine whether rosuvastatin administered during reperfusion modifies infarct size and the recovery of postischemic ventricular dysfunction in normocholesterolemic hypercholesterolemic rabbits. In addition, we also evaluated role matrix metalloproteinase type 2 (MMP)-2 activation. Langendorff-perfused rabbit hearts were subjected 30 minutes 120 reperfusion. group...
Calcineurin is a Ca(2+)/calmodulin-dependent protein phosphatase that induces myocardial growth in response to several physiological and pathological stimuli. inhibition, induced either via cyclosporine or genetically, can decrease hypertrophy secondary pressure overload without affecting left ventricular (LV) systolic function. Since also affect LV diastolic function, the goal of this study was examine effects chronic (2 wk aortic banding) transgenic (Tg) mice overexpressing Zaki-4beta...
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from beginning of infection, is critical for control parasite proliferation and evolution Chagas disease. Peroxisome proliferator-activated receptors (PPAR)-α, are known to modulate inflammation. In this study we investigated whether a PPAR-α agonist, Fenofibrate, improves function parameters in murine model T. BALB/c mice were sequentially infected with two strains...
Adenosine is involved in classic preconditioning most species and acts especially through adenosine A 1 3 receptors. The aim of the present study was to evaluate whether remote ischemic (rIPC) activates receptors improves mitochondrial function, thereby reducing myocardial infarct size. Isolated rat hearts were subjected 30 min global ischemia 60 reperfusion [ischemia-reperfusion (I/R)]. In a second group, before isolation heart, rIPC protocol (3 cycles hindlimb I/R) performed. Infarct size...
Dystrophin is responsible for the mechanical stabilization of sarcolemma, and it has been shown that one most sensitive proteins to ischemic injury. However, enzyme this proteolysis still unknown. Isolated rabbit hearts were subjected 30 min global ischemia with without reperfusion (180 min) determine whether dystrophin cleaved by matrix metalloproteinase (MMP)-2 during acute preconditioning (PC) prevents breakdown through MMP-2 inhibition. The activity was evaluated zymography using...
IL-10 is an anti-inflammatory cytokine that plays a significant role in the modulation of immune response many pathological conditions, including infectious diseases. Infection with Trypanosoma cruzi (T. cruzi), etiological agent Chagas disease, results ongoing inflammatory may cause heart dysfunction, ultimately leading to failure. Given its and nature, this work we analyzed whether lack hinders effects fenofibrate, PPARα ligand, murine model disease (CHD) using knockout (IL-10 KO) mice....
Chagas disease, caused by Trypanosoma cruzi, stands as the primary cause of dilated cardiomyopathy in Americas. Macrophages play a crucial role heart's response to infection. Given their functional and phenotypic adaptability, manipulating specific macrophage subsets could be vital aiding essential cardiovascular functions including tissue repair defense against PPARα are ligand-dependent transcription factors involved lipid metabolism inflammation regulation. However, fenofibrate, ligand,...
β-blockers are no longer considered as first-line antihypertensive drugs due to their lower cardioprotection.Considering the differences in pharmacological properties of β-blockers, present work compared effects third-generation - carvedilol and nebivolol with a agent amlodipine on hemodynamic parameters, including short-term blood pressure variability (BPV), ability prevent target organ damage spontaneously hypertensive rats (SHR). SHR were orally treated carvedilol, nebivolol, atenolol, or...
The α1-adrenergic receptors (α1-ARs) are involved in preconditioning. Given that certain intracellular pathways seem to be shared by preconditioning and postconditioning, it is possible postconditioning could also mediated α1-ARs. objective was evaluate, analyzing infarct size, if α1-ARs activation trigger determine Akt glycogen synthase kinase 3β (GSK-3β) phosphorylation. Langendorff-perfused rat hearts were subjected 30 minutes of ischemia 120 reperfusion (I/R; n = 8). After global...
The involvement of natriuretic peptides was studied during the hypertrophic remodeling transition mediated by sequential exposure to chronic hemodynamic overload. We induced hypertension in rats pressure (renovascular) or volume overload (DOCA-salt) 6 and 12 weeks treatment. also consecutive combination both models inverse sequences: RV weeks/DS DS weeks/RV weeks. All treated groups developed hypertension. Cardiac hypertrophy left ventricular ANP gene expression were more pronounced single...