A5089209738- Viral Infectious Diseases and Gene Expression in Insects
- Hormonal Regulation and Hypertension
- Insect Resistance and Genetics
- Renin-Angiotensin System Studies
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Heart Failure Treatment and Management
- Insect symbiosis and bacterial influences
- Entomopathogenic Microorganisms in Pest Control
- Blood Pressure and Hypertension Studies
- Mosquito-borne diseases and control
- Liver Disease Diagnosis and Treatment
- Ion Transport and Channel Regulation
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- Invertebrate Immune Response Mechanisms
- GDF15 and Related Biomarkers
- Cancer Research and Treatments
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Sulfur Compounds in Biology
- Genomics and Chromatin Dynamics
- Dental Trauma and Treatments
- Parasitic Diseases Research and Treatment
- Plant Virus Research Studies
National University of Quilmes
2014-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2010-2023
University of Buenos Aires
2011-2021
Centre for Life
2019
University College London
2019
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2010
Mosquitoes are the primary vectors of arthropod-borne pathogens. Aedes aegypti is one most widespread mosquito species worldwide, responsible for transmitting diseases such as Dengue, Zika, and Chikungunya, among other medically significant viruses. Characterizing array viruses circulating in mosquitoes, particularly , a crucial tool detecting developing novel strategies to prevent arbovirus outbreaks. In this study, we address implementation sequencing analysis pipeline based on Oxford...
Baculoviruses are viral pathogens that infect different species of Lepidoptera, Diptera, and Hymenoptera, with a global distribution. Due to their biological characteristics the biotechnological applications derived from these entities, Baculoviridae family is an important subject study manipulation in natural sciences. With advent RNA interference mechanisms, presence baculoviral genes do not code for proteins but instead generate transcripts similar microRNAs (miRNAs) has been described....
The adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and advance into mitosis. Therefore, diseases characterized by lost contractile tissue usually evolve myocardial remodeling heart failure. Analyzing cardiac transcriptome at different developmental stages in large mammal closer human than laboratory rodents may serve disclose positive negative regulators potentially targetable induce regeneration clinical setting. Thus we aimed characterizing...
Hemodynamic parameters and natriuretic peptide levels were evaluated in cardiac hypertrophy produced by sequentially applied renovascular (RV) deoxycorticosterone acetate-salt (DS) models of hypertension. We studied hypertensive rats RV or DS treatment at 2 4 wk, as well the combination wk each an inverse sequence: wk/DS (RV2/DS2) wk/RV (DS2/RV2). The vivo function, interstitial fibrosis, synthesis secretion types A (ANP) B (BNP) peptides monitored compared with their corresponding sham...
In the kidney, a high salt intake favors oxidative stress and hypoxia causes development of fibrosis. Both atrial natriuretic peptide (ANP) inducible factor (HIF-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>) exert cytoprotective effects. We tested hypothesis that renal expression ANP HIF-1<mml:math id="M3"><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>is involved in mechanism responding to produced kidneys rats...
Summary In association with hepatitis B virus ( HBV ), delta HDV ) is a subviral agent that may promote severe acute and chronic forms of liver disease. Based on the percentage nucleotide identity genome, was initially classified into three genotypes. However, since 2006, original classification has been further expanded eight clades/genotypes. The intergenotype divergence be as high 35%‐40% over entire RNA whereas sequence heterogeneity among isolates given genotype <20%; furthermore,...
The involvement of natriuretic peptides was studied during the hypertrophic remodeling transition mediated by sequential exposure to chronic hemodynamic overload. We induced hypertension in rats pressure (renovascular) or volume overload (DOCA-salt) 6 and 12 weeks treatment. also consecutive combination both models inverse sequences: RV weeks/DS DS weeks/RV weeks. All treated groups developed hypertension. Cardiac hypertrophy left ventricular ANP gene expression were more pronounced single...
Baculoviruses are entomopathogens that carry large, double-stranded circular DNA genomes and infect insect larvae of Lepidoptera, Hymenoptera Diptera, with applications in the biological control agricultural pests, production recombinant proteins as viral vectors for various purposes mammals. These viruses have a variable genetic composition differs between species, some sequences shared by all known members, others lineage-specific or unique to isolates. Based on analysis nearly 300...
Dyskerin is a conserved nucleolar protein. Several related genetic diseases are caused by defects in dyskerin. We hypothesized that having comprehensive bioinformatic analysis of dyskerin will help to develop new drugs for this diseases. predicted protein domains and compared sequences structures detect the universe dyskerin-like proteins. identified features shared three superkingdoms. analyzed phylogenetic diversity, confirming there strong structural conservation. Also, we studied...
Microorganisms associated with mosquitoes have fundamental roles, not only in their nutrition, but also physiological and immunological processes, adaptation to the environment as well. Studies on mosquito hologenomes increased significantly during last years, achieving important advances characterization of "core bacteriome" some species health importance. However, fungal mycobiome has been exhaustively researched, especially throughout life cycle hematophagous species. In this work,...
To understand the mechanism of replication used by baculoviruses, it is essential to describe all factors involved, including virus and host proteins sequences where DNA synthesis starts. A lot work on this topic has been done, but there still confusion in defining what sequence/s act such functions, not very well understood. In work, we performed an AgMNPV kinetics into susceptible UFL-Ag-286 cells estimate viral genome rates. We found that exponentially increases two different phases are...
Spodoptera ornithogalli (Guenée) (Lepidoptera: Noctuidae) is an important pest in different crops of economic relevance America. For its control, strategies that include chemicals are usually used; so, the description entomopathogens would be very useful for formulation biopesticides. In this regard, two baculoviruses affecting S. were isolated Colombia, with one them being NPV and other a GV. Ultrastructural, molecular, biological characterization showed both isolates possess 38 core genes...
The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy increase natriuretic peptides (NPs). profiles ANP BNP synthesis secretion have been investigated models hypertension; however, the evolution these during acute chronic periods overload-induced is still unknown. For this reason, we studied DOCA-salt treated Sprague-Dawley rats at weeks 2, 4, 6 12 correlated with hypertension. Cardiac had a positive correlation...
Baculoviruses are insect pathogens that characterized by assembling the viral dsDNA into two different enveloped virions during an infective cycle: occluded (ODVs; immersed in a protein matrix known as occlusion body) and budded (BVs). ODVs responsible for primary infection midgut cells of susceptible larvae thanks to per os infectivity factor (PIF) complex, composed at least nine essential proteins. Among them, P74 is crucial whose activity has been identified virus-specific. In this work,...
Abstract Furcraea necrotic streak virus (FNSV) is the causative agent of disease, also known as macana in fique crops ( spp.) resulting damage to leaf fibres and economic losses. The rhizospheric fungus Olpidium spp. present roots affected plants may play a role disease transmission. FNSV infection fungi were examined macanavirus‐diseased Colombia. Spherical, icosahedral (24.7 ± 1.98 nm), non‐enveloped virions with granular surface isolated from field showing signs viral genome was...