A5076857082- Congenital Heart Disease Studies
- Vascular anomalies and interventions
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Semiconductor materials and devices
- Cardiac Arrest and Resuscitation
- Advanced Chemical Sensor Technologies
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Mechanical Circulatory Support Devices
- Electrochemical Analysis and Applications
- Uterine Myomas and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Soft tissue tumors and treatment
- PI3K/AKT/mTOR signaling in cancer
- Coronary Interventions and Diagnostics
- Extracellular vesicles in disease
National Taiwan University Hospital
2012-2024
National Taiwan University
2021-2024
Cardiovascular Research Center
2018
In this letter, we demonstrate a fully inkjet-printed electrochemical lactate sensor. The sensor is on flexible substrate, Kapton film, where silver nanoparticles (Ag NPs) are printed as conductive electrodes. working and reference electrodes of the Ag NPs/NiO NPs/Polyurethane (PU) Ag/AgCl(s)/PU layers respectively. PU film can not only prevent annihilation NPs resulting from dissolution formation AgCl in phosphate-buffered saline (PBS) but also stabilize lactic acid measurements by...
Abstract Background Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and treatment with sodium bicarbonate given to correct metabolic in the ICU are poorly understood. Method This was an international retrospective observational study 18 ICUs Australia, Japan, Taiwan. Adult patients were consecutively screened, those early (pH < 7.3 Base Excess –4 mEq/L, within 24-h admission) included. Screening continued until 10 who received did not...
Comparison of Skin Toxic Effects AssociatedWith Gefitinib, Erlotinib, or Afatinib Treatment for Non-Small Cell Lung Cancer Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used to treat non-small cell lung cancer.Four major skin toxic effects with different incidences reported from clinical studies, including acneiform eruption (60%-94%), pruritus (16%-60%), xerosis (4%-38%), and paronychia (6%-12%). 1,2However, a direct comparison the severities 4...
Various clinical studies have shown that myocardial troponin T (cTnT) is highly correlated with acute infarction (AMI). A sensitive molecularly imprinted polymer (MIP) sensing electrode for the detection of cTnT in patients' blood serum can enable cost-effective, rapid, and real-time testing patients requiring intensive care. However, existing MIP-based does not perform well low-concentration (<0.2 ng/mL). In this study, a new type electrode, an anodic aluminum oxide (MIP/AAO) nanocomposite...
The use of RDV in SAVR is associated with risk conduction abnormality requiring PPM implantation, when compared to conventional bioprosthetic valves. We aimed evaluate the outcome after selective placement annular compression sutures during surgical aortic valve replacement (SAVR) using Intuity rapid deployment (RDV). This a retrospective study prospectively enrolled patients receiving RDV. Selective commissural suture was assessed for all based on their morphology. Outcomes including...
Visual Abstract Export Background and objectives There is increasing evidence that microRNAs (miRNAs) play crucial roles in the regulation of neointima formation. However, translational role miRNAs dialysis vascular access limited. Design, setting, participants, & measurements miRNA expression tissues was assessed by using venous harvested from ten patients on who received revision or removal surgery, were predialysis creation surgery arteriovenous fistulas served as controls. To extend...
Intravascular leiomyomatosis (IVL) is relatively rare. The optimal surgical method and long-term outcomes are not completely understood. Medical records between 2007 2017 in our hospital were analyzed to identify IVL cases with intervention. Their medical records, operative details, follow-up collected by chart review telephone communication. Eight patients included the study, accounting for 0.26% of all uterine leiomyoma cases. Primary was confined pelvic cavity three patients, extended...
This article presents a cardiac troponin T (cTnT) sensing electrode fabricated using molecular imprinted polymer (MIP) for clinical studies the first time. The MIP-based is an electrochemically polymerized o-phenylenediamine film, which can detect cTnT concentrations ranging from 0.017 to 10 ng/mL in 15 min and be reused more than six times without any performance degradation. There are no size thickness effects on electrode, showing its high potential cost-effective sensor applications....
Blood reflux and metabolic regulation play important roles in chronic venous disease (CVD) development. Histone deacetylases (HDACs) DNA methyltransferases (DNMTs) serve as repressors that inhibit signaling, which is induced by proatherogenic flow to promote aortic endothelial cell (EC) dysfunction atherosclerosis. The aim of this study was elucidate the relationship between blood epigenetic factors HDACs DNMTs CVD. Human varicose veins with different levels versus normal were examined....
MicroRNA-10a (miR-10a) inhibits transcriptional factor GATA6 to repress inflammatory GATA6/VCAM-1 signaling, which is regulated by blood flow affect endothelial function/dysfunction. This study aimed identify the expression patterns of miR-10a/GATA6/VCAM-1 in vivo and their implications pathophysiology human coronary artery disease (CAD), i.e., atherosclerosis. Human atherosclerotic arteries nondiseased were used detect expressions pathogenic vs. normal conditions. In addition, sera from CAD...
Warfarin treatment benefits vary with the clinical skill of warfarin dosage adjustment. However, optimal adjustment in response to out-of-range international normalized ratio (INR) is not completely understood. Data for 2014-2016 from an integrated health care information system a single hospital were analyzed. Based on their fluctuation (WDF), defined as standard deviation all prescribed dosages divided by mean dosage, patients classified into Groups 1 (0-0.10), 2 (0.10-0.20), and 3...
Surgical correction of transposition the great arteries was proposed by many in past half-century and claimed as anatomical correction, but treatment choice ever changing. The current technique usually includes Lecompte maneuver to bring pulmonary bifurcation front aorta. Although ventricular-arterial connection is corrected, it not "normal." This review describes an innovative reconstruct spiral fashion, which natural relationship aorta artery. surgical principles nature even distribution...
Abstract Rationale, Aims, and Objectives A more effective allocation of critical care resources is important as the cost intensive increases. model has been developed to predict probability in‐hospital death among patients who received extracorporeal membrane oxygenation (ECMO). Cost‐effectiveness analyses (CEA) were performed regarding relationship between hospitalization expenses predicted survival outcomes. Methods Adult ECMO in a medical center Taiwan (2005–2016) included. logistic...
In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode pinhole, mushroom, coral-shaped nanostructures can achieve limit (LoD) 13.02, 7.835, 4.462 pg/ml, respectively. Surface roughness porosity emerge as pivotal factors influencing performance. Increasing...
Abstract This study introduces a novel microneedle‐based lactate sensor with SU‐8 micropillar enhancement, designed for real‐time monitoring in dynamic environments. Utilizing inkjet‐printing technology, the demonstrates enhanced sensitivity and reduced limit of detection (LoD), addressing critical challenges clinical applications like hemodialysis patient ICU. Design enhancements medical steel needle improve stress resistance during insertion, contributing to sensor's reliability. The...
Sinus of Valsalva aneurysm (SVA) is an uncommon cardiac defect accounting for only 1% congenital anomalies and the most common complication ruptured into atrium or ventricle. Very late recurrence SVA after patch repair extremely rare. We present a case 57-year-old man had received at 19 ages. In clinics, he presented with exertional dyspnea leg swelling. The serial examination disclosed bicuspid aortic valve very rupture connecting to right atrium. After surgical again, was discharged...
In this paper, we demonstrate a non-enzymatic microsensing needle for lactate detection in dynamic environment mimicking the urine flowing through pipeline of bag. Experimental results show microneedle can exhibit similar linearity 0.97, sensitivity 5.9 x 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> nA/mM·mm xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and LoD (Limit Detection) 0.29 mM both under static where flow rate ranges...
A 77-year-old man developed fever, dyspnoea, and bilateral lung oedema over a 3 days course. Echocardiography found an elongated hyperechoic mass protruding from the aortic wall near left coronary cusp, oscillating in root ( Panel , Supplementary material online, Video S1 ). No significant valvular dysfunction or intra-cardiac thrombus was found. The blood cultures grew methicillin-resistant Staphylococcus aureus . Despite of adequate antibiotics coverage, patient progressed into …
In this paper, we demonstrate real-time hydrogen sulfide monitoring in liquid using a flexible inkjet printed Ag/rGO/Nafion-Ru(NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) xmlns:xlink="http://www.w3.org/1999/xlink">6<sup>3+/2+</sup></sub> two-electrode amperometric sensor. The electrodes are inkjet-printed on substrate, Kapton film, where silver nanoparticles (Ag NPs) as conductive electrodes. working and reference Ag/AgCl...