A5048758091- Dental materials and restorations
- Oral and Maxillofacial Pathology
- AI in cancer detection
- Dental Radiography and Imaging
- Oral microbiology and periodontitis research
- Cell Image Analysis Techniques
- Oral Health Pathology and Treatment
- Medical Image Segmentation Techniques
- Image Retrieval and Classification Techniques
- Endodontics and Root Canal Treatments
- Gene expression and cancer classification
- Dental Research and COVID-19
- Morphological variations and asymmetry
- Dental Implant Techniques and Outcomes
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- Digital Imaging for Blood Diseases
- dental development and anomalies
- Bone Tissue Engineering Materials
- Advanced X-ray and CT Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Soft tissue tumor case studies
- Dental Health and Care Utilization
- Complex Systems and Time Series Analysis
- Periodontal Regeneration and Treatments
University of Birmingham
2015-2024
University College Birmingham
2016-2017
University of Dental Medicine
2001-2015
Universidade de São Paulo
2015
Birmingham Children's Hospital
2014
Birmingham Dental Hospital
1992-2013
Northwestern University
1994
Birmingham and Midland Eye Centre
1993
Kagoshima University
1989-1992
Microscopy images of stained cells and tissues play a central role in most biomedical experiments routine histopathology. Storing colour histological digitally opens the possibility to process numerically distribution intensity extract quantitative data. Among those numerical procedures are deconvolution, which enable decomposing an RGB image into channels representing optical absorbance transmittance dyes when their representation is known. Consequently, range new applications become...
Bands of colour extending laterally from the dorsal to ventral trunk are a common feature mouse chimeras. These stripes were originally taken as evidence directed dorsoventral migration melanoblasts (the embryonic precursors melanocytes) they colonize developing skin. Depigmented 'belly spots' in mice with mutations receptor tyrosine kinase Kit thought represent failure this colonization, either due impaired or proliferation. Tracing single melanoblast clones, however, has revealed diffuse...
The molecular immune response of the pulpal tissue during chronic carious infection is poorly characterized. Our objective was to examine expression potential mediators inflammation, correlate their levels with disease severity, and determine cellular localization key molecules. Results indicated that there significantly increased transcriptional activity in compared healthy pulp, increase correlated positively severity. Semiquantitative reverse transcriptase PCR analysis 10 samples S100...
The immunocytochemical expression of cadherins and catenins was examined during the process oral carcinogenesis by comparing their in normal dysplastic epithelium with primary metastatic carcinomas. While control showed distribution for P E cadherin catenins, severe dysplasia P-cadherin upregulated. In other cases carcinoma-in-situ adjacent to infiltrating carcinomas, membranous reduced or lost. changes E-cadherin suggest that disruption E-cadherin/catenin complex is a late event associated...
Quantification of the local complexity epithelial-connective tissue interface (ECTI) in normal mucosa, epithelial dysplasia, and squamous cell carcinoma floor mouth was investigated by estimating connected fractal dimension profiles from histological sections. The use certain parameters distribution dimensions ECTI classifies cases belonging to these three histopathological diagnoses with 85 per cent accuracy means linear discriminant analysis. values were also used produce colour-coded...
The spontaneous emergence of phenotypic heterogeneity in clonal populations mammalian cells vitro is a rule rather than an exception. We consider two simple, mutually non-exclusive models that explain the generation diverse cell types homogeneous population. In first model, switch consequence extrinsic factors. Initially identical may become different because they encounter local environments induce adaptive responses. According to second intrinsic occur even environments.We have...
Summary We present an approach for automatic threshold segmentation of greyscale images. The procedure is inspired by a reinterpretation the strategy observed in human operators when adjusting thresholds manually and interactively means ‘slider’ controls. translates into two methods. first one suitable single or multiple global to be applied globally images consists searching value that generates phase whose boundary coincides with largest gradients original image. second method variation,...
Epithelial-mesenchymal transition (EMT) is potentially involved in increasing metastasis of oral squamous cell carcinoma (OSCC). Periodontal pathogens are well-known for their ability to induce intense immune responses and here we investigated whether they inducing EMT. Cultures OSCC line (H400) were treated separately with heat-killed periodontal F. nucleatum, or P. gingivalis E. coli LPS 8 d. EMT-associated features assayed using sq-PCR PCR-arrays, EMT-related markers, ELISAs TGF-β1,...
Background and Objective Epithelial‐mesenchymal transition ( EMT ) is a process by which epithelial cells acquire mesenchymal‐like phenotype this may be induced exposure to gram‐negative bacteria. It has been proposed that responsible for compromising barrier function in the pathogenesis of several diseases. However, possible role periodontitis not previously investigated. The aim study therefore was investigate whether gram‐negative, anaerobic periodontal pathogens could trigger primary...
The fractal dimension of the retinal vasculature and isolated venous arterial trees down to a caliber 40 μm was estimated in 23 routine fluorescein angiograms normal retinas. Fractal determined with method based on box counting theorem. This is less susceptible radial architecture vascular tree than those previously reported (mass-radius relation density-density correlation function). Two scale ranges different were consistently present. dimensions showed no significant difference between...
To investigate the perception of facial asymmetry in young adults to identify amounts chin that can be regarded as normal and may benefit from correction.Three-dimensional (3D) images 56 individuals mixed ethnicity were obtained used produce average 3D male female faces. Distortion was then applied these faces using a graphics package simulate different point asymmetry. Five observer groups (lay individuals, dental students, care professionals, practitioners, orthodontists) assessed timed...
This paper reports the detailed calibration of new Periotron 8000® with different fluids and uses method least squares to derive polynomial regression equations up 6th order, investigate most accurate descriptor resulting lines. The use a 4th order equation (recommended by manufacturer) provided better coefficients determination ( R 2 : 0.999) root mean square errors (RMSE = 1.6) than either linear 0.986, RMSE 10.9) or quadratic models 0.998, 3.2). Data derived using manufacturer's MLCONVERT...
Damage to tooth root surfaces may occur during ultrasonic cleaning with both piezoelectric and magnetostrictive scalers. It is unclear which mechanism causes more damage or how their of action leads such damage. Our null hypothesis that tooth-surface defect dimensions, resulting from instrumentation scalers, are independent whether the scaler probe piezoelectric. Piezoelectric probes were placed into contact against polished dentin samples (100 g/200 g). Resulting evaluated a laser metrology...