A5019286475- Advancements in Battery Materials
- Supercapacitor Materials and Fabrication
- Cancer-related molecular mechanisms research
- Rock Mechanics and Modeling
- Advanced Battery Materials and Technologies
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Advanced Battery Technologies Research
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Dupuytren's Contracture and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Angiogenesis and VEGF in Cancer
- Advanced Neuroimaging Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
- Glioma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Fault Detection and Control Systems
- RNA modifications and cancer
- Crystallization and Solubility Studies
- Cancer Cells and Metastasis
- Entrepreneurship Studies and Influences
Penn State Milton S. Hershey Medical Center
2024-2025
Affiliated Hospital of North Sichuan Medical College
2024-2025
Sichuan University
2015-2024
Weatherford College
2020-2024
State Key Laboratory of Biotherapy
2022-2024
Second Affiliated Hospital of Nanchang University
2010-2024
Nanchang University
2010-2024
Beijing Sanbo Brain Hospital
2020-2024
Capital Medical University
2020-2024
Huazhong University of Science and Technology
2007-2023
Abstract The association of necrosis in tumors with poor prognosis implies a potential tumor-promoting role. However, the mechanisms underlying cell death this context and how damaged tissue contributes to tumor progression remain unclear. Here, we identified p38 mitogen-activated protein kinases (p38 MAPK, a.k.a. p38) as key player promoting inflammatory response ischemic stress associated necrotic tumors. We found that glioblastoma (GBM) cells expressing patient-derived Kirsten rat sarcoma...
SiNP-based composites for advanced LIB anodes are discussed from the perspective of composition and electrochemical effects.
This study aims to overcome the drawbacks associated with hydroxyapatite (HAP) dense structures after sintering, which often result in undesirable features such as large grain size, reduced porosity, high crystallinity, and low specific surface area. These characteristics hinder osseointegration limit clinical applicability of material. To address these issues, a new method involving preparation hollow (hHAP) microspheres has been proposed. exhibit distinctive traits including weak...
Perfluorinated compounds (PFCs) were reported to result in the endocrine disruption by activating estrogen receptor (ER) and inducing ER-mediated transcriptions. The aim of present work was perform cross-species comparisons on characteristics eight PFCs binding humans ERα rats ERα. In work, vivo tests, including serum estradiol level assay immunohistochemical staining, fluorescence molecular models applied. Based experiments, exposure PFOA PFOS female proved increase expression terus,...
Homo sapiens caseinolytic protease P (HsClpP) plays an important role in maintaining mitochondrial proteostasis. Activating HsClpP has been proved to be a potential strategy for cancer therapy. In this paper, novel class of agonists is designed and synthesized using position shift based on the imipridone ONC201. Among these newly derivatives, compound 16z exhibits remarkably enhanced antitumor activity (IC50 = 0.04 μM against HCT116 cells). It can improve thermal stability induce...
Homo sapiens caseinolytic protease P (HsClpP) activation is a promising strategy for colon cancer treatment. In this study, CCG1423 was identified as selective activator of HsClpP. After optimization, NCA029 emerged the most potent compound, with an EC50 0.2 μM against Molecular dynamics revealed that affinity YYW aromatic network crucial its selectivity toward Furthermore, displayed favorable pharmacokinetics and safety profiles significantly inhibited tumor growth in HCT116 xenografts,...
Hepatocellular carcinoma (HCC) often presents with satellite nodules, rendering current curative treatments ineffective in many patients. The heterogeneity of HCC is a major challenge personalized medicine. emergence spatial transcriptomics (ST) provides powerful strategy for delineating the complex molecular landscapes tumours.In this study, tissue-wide gene expression tumour and adjacent nonneoplastic tissues using ST technology were investigated. transcriptomes nearly 10,820 tissue...
Introduction Gliomas are the most common primary intracranial tumors, known for their high invasiveness and destructiveness. Sialic acid-binding immunoglobulin-like lectin 7 (SIGLEC7) is present in various immune cells, especially macrophages, significantly affects homeostasis cancer cell response. However, research on role prognostic impact of SIGLEC7 glioma patients currently limited. Methods We utilized transcriptomic data from 702 The Cancer Genome Atlas (TCGA) 693 Chinese Glioma (CGGA),...
To investigate differences in the microstructure of spinothalamic tract (STT) white matter people with chronic neck and shoulder pain (CNSP) using diffusion tensor imaging, to assess its correlation intensity duration pain. A 3.0T MRI scanner was used perform imaging scans on 31 CNSP 24 healthy controls (HCs), employing Automatic Fiber Segmentation Quantification (AFQ) method extract STT quantitatively analyze fractional anisotropy (FA) mean diffusivity (MD), reflecting microstructural...
Objective To explore the changes in white matter microstructure of ascending pain conduction pathways patients with chronic neck and shoulder (CNSP) using combined brain spinal cord diffusion tensor imaging techniques, to assess its correlation clinical indicators cognitive functions. Materials methods A 3.0T MRI scanner was used perform scans on 31 CNSP 24 healthy controls (HCs), extracting spinothalamic tract (STT) quantitatively analyzing fractional anisotropy (FA) mean diffusivity (MD)...
Aggressive tumor cells can mimic embryonic vasculogenic networks and form mimicry (VM). Preliminary studies demonstrated that hypoxia promote VM formation; however, the underlying mechanism remains unclear. The present study aimed to investigate role of Twist1‑Bmi1 connection in hypoxia‑induced formation mechanism. In vitro experiments, western blot analysis upregulated expression Twist1, Bmi1, epithelial‑mesenchymal transition (EMT) markers, stem cell markers VM‑associated markers. 3D...
As the rate-limiting enzyme in fatty acid biosynthesis,