A5102578715- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Mosquito-borne diseases and control
- interferon and immune responses
- Fish biology, ecology, and behavior
- Fish Ecology and Management Studies
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Invertebrate Immune Response Mechanisms
- FOXO transcription factor regulation
- Bat Biology and Ecology Studies
- Physiological and biochemical adaptations
- RNA modifications and cancer
- Fish Biology and Ecology Studies
- Adipose Tissue and Metabolism
- Dietary Effects on Health
Max Planck Institute for Biology of Ageing
2021-2024
University of Cologne
2023-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2023-2024
Late-life-initiated dietary interventions show limited efficacy in extending longevity or mitigating frailty, yet the underlying causes remain unclear. Here we studied age-related fasting response of short-lived killifish Nothobranchius furzeri. Transcriptomic analysis uncovered existence a fasting-like transcriptional program adipose tissue old fish that overrides feeding response, setting persistent metabolic quiescence. The fasting-refeeding cycle triggers an inverse oscillatory...
Aging is associated with an increase in body fat mass and a concomitant decrease lean bone density mammals. Body adiposity can also be redistributed age, resulting abdominal accumulation subcutaneous reduction. In addition, specific variation distribution considered to risk factor for number of age-related metabolic disorders. Micro computed tomography (micro-CT) nondestructive high-resolution imaging method that uses planar X-ray images captured at various angles around sample interest...
Cyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates. In mammals, GMP-AMP synthase (cGAS) has been shown bind intracellular DNA and catalyze the production of 2'3' cGAMP, which signals downstream effectors regulate immune function, interferon signaling, antiviral response. Despite importance CDNs, sensitive accurate methods measure their levels in vivo lacking....
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on downstream outputs, little is known about upstream inputs that regulate these live organism. Here, we found knockdown various glucose metabolic enzymes decreases MML-1...
Abstract The cGAS/STING pathway is a central innate immune signaling whose chronic activation has been implicated in numerous age-related pathologies, yet its impact on life span itself unknown. Here we engineered knockouts of this the killifish Nothobranchius furzeri , and assessed physiology aging. In vitro loss cGAS or STING mitigated DNA damage-induced senescence cultured fibroblasts. vivo knockout unexpectedly led to low-grade inflammation. It also attenuated changes gene expression...
Blood withdrawal is a common procedure performed on laboratory animals to monitor key processes and indicators of fish health physiology, such as hematopoiesis, hemostasis, lipid glucose metabolism. Moreover, the ability extract blood with minimal invasiveness without sacrificing enables repeated sampling, allowing both longitudinal studies individual animals, well reducing number experimental needed in study. The African turquoise killifish an emerging animal model that progressively being...
Abstract The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on downstream outputs, little is known about upstream inputs that regulate these live organism. Here, we found knockdown various glucose metabolic enzymes decreases MML-1...
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on downstream outputs, little is known about upstream inputs that regulate these live organism. Here, we found knockdown various glucose metabolic enzymes decreases MML-1...
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on downstream outputs, little is known about upstream inputs that regulate these live organism. Here, we found knockdown various glucose metabolic enzymes decreases MML-1...
Abstract Late-life-initiated dietary interventions negligibly extend longevity or reduce frailty, yet the reason remains unknown. We investigated age-related changes associated with fasting response in adipose tissue of short-lived killifish N. furzeri . Transcriptomic analysis revealed presence a fasting-like transcriptional program (FLTP) old animals that is irrespective their nutritional status and characterized by widespread suppression anabolic processes. FLTP reduced expression AMPK γ1...