A5077788853- Chromosomal and Genetic Variations
- Malaria Research and Control
- Prostate Cancer Diagnosis and Treatment
- Mosquito-borne diseases and control
- Viral-associated cancers and disorders
- Diversity and Career in Medicine
- Trypanosoma species research and implications
- Lung Cancer Research Studies
- RNA modifications and cancer
- Vibrio bacteria research studies
- Medical Education and Admissions
- Hospital Admissions and Outcomes
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Global Cancer Incidence and Screening
- Neuroendocrine Tumor Research Advances
- Vaccine Coverage and Hesitancy
- Economic and Financial Impacts of Cancer
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Prenatal Substance Exposure Effects
- Bladder and Urothelial Cancer Treatments
Providence College
2025
Brown University
2019-2025
Columbia University Irving Medical Center
2024
John Brown University
2024
Miriam Hospital
2022
Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 phfrp3 genes make parasites undetectable by RDTs. We analyzed 19,313 public whole-genome-sequenced P. field samples to understand these better. Pfhrp2 deletion only occurred chromosomal breakage with subsequent telomere healing. Pfhrp3 involved loss from pfhrp3 the showed three patterns: no other associated rearrangement evidence healing at breakpoint...
Endemic Burkitt lymphoma (eBL) is one of the most prevalent cancer in children sub-Saharan Africa, and while prior studies have found that Epstein-Barr virus (EBV) type variation may alter tumor driver genes necessary for survival, precise relationship between EBV EBV-associated tumorigenesis remains unclear due to lack scalable, cost-effective, viral whole-genome sequencing from samples. This study introduces a rapid cost-effective method enriching, sequencing, assembling accurate genomes...
Although surgery is less commonly selected as treatment for localized prostate cancer (PCa) patients age, outcomes among older treated with radical prostatectomy remain unclear. The objective of this study was to compare survival across non-definitive therapy (NDT), radiotherapy, and (RP) men than 80 years old. Using the SEER-17 database, we identified ≥80 at diagnosis in 2000-2021 who were initially managed NDT, or RP. We compared overall (OS) cancer-specific (PCSS). 53,437 PCa≥80 including...
Although Epstein-Barr virus (EBV) plays a role in Burkitt lymphoma (BL) tumorigenesis, it is unclear if EBV genetic variation impacts clinical outcomes. From 130 publicly available whole-genome tumor sequences of EBV-positive BL patients, we used least absolute shrinkage and selection operator (LASSO) regression Bayesian variable models within Cox proportional hazards framework to select the top variants, putative driver genes, features associated with patient survival time. These were...
Abstract Endemic Burkitt lymphoma (eBL) is one of the most prevalent cancer in children sub-Saharan Africa, and while prior studies have found that Epstein-Barr virus (EBV) type variation may alter tumor driver genes necessary for survival, precise relationship between EBV EBV-associated tumorigenesis remains unclear due to lack scalable, cost-effective, viral whole-genome sequencing from samples. This study introduces a rapid cost-effective method enriching, sequencing, assembling accurate...
Clinical guidelines state that neoadjuvant chemotherapy should be administered before surgery in muscle invasive urinary bladder small cell neuroendocrine carcinoma. Recently described marker insulinoma-associated protein 1 (INSM1) has been reported to sensitive and specific for differentiation, however, its efficacy tract carcinoma is not well established. This study examines immunohistochemical expression of INSM1 on whole tissue sections compares with established markers....
Background In May 2012, the US Preventive Services Task Force (USPSTF) recommended against prostate‐specific antigen (PSA)–based screening for prostate cancer (PCa), assigning it a grade D. This decision then was modified in 2018 to C men aged 55 69 years. The authors hypothesized that changes practices would reduce survival outcomes both Black and White but maintain racial discrepancies outcomes. Methods Using Surveillance, Epidemiology, End Results database, examined PCa‐specific based on...
Although the clinical benefits of pelvic lymph node dissection (PLND) at time radical prostatectomy for prostate cancer remain uncertain, major guidelines recommend PLND based on risk profile. Thus, objective this study was to examine association between and survival among patients undergoing RP stratified by Gleason grade group (GG) with aim allowing physicians make more informed care decisions about potential risks PLND. From SEER-17 database, we examined overall (OS) cancer-specific...
Plasmodium vivax transmission occurs throughout the tropics and is an emerging threat in areas of falciparum decline, causing relapse infections that complicate treatment control. Targeted sequencing for P. has been widely deployed to detect population structure geographic spread antimalarial diagnostic resistance. However, there are fewer such tools vivax. Leveraging global variation data, we designed four molecular inversion probe (MIP) genotyping panels targeting geographically...
To develop personalized treatments for diseases, it is essential that they reflect the population of individuals may be affected by a given disease. Amidst claims there racial disparities in research populations, have been no direct studies to explore this disparity disease incidence and projects involve genomic sequencing. The precise relationship between underrepresentation certain races sequencing health outcomes relative these unknown. Here, we examine representation national datasets...
ABSTRACT While Epstein-Barr virus (EBV) plays a role in Burkitt lymphoma (BL) tumorigenesis, it is unclear if EBV genetic variation impacts clinical outcomes. From 130 publicly available whole-genome tumor sequences of EBV-positive BL patients, we used least absolute shrinkage and selection operator (LASSO) regression Bayesian variable models within Cox proportional hazards framework to select the top variants, putative driver genes, features associated with patient survival time. These were...
Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 phfrp3 genes make parasites undetectable by RDTs. To better understand these deletions, we analyzed 19,289 public whole-genome-sequenced P. field samples. Pfhrp2 deletion only occurred chromosomal breakage with subsequent telomere healing. Pfhrp3 involved loss from pfhrp3 to the showed 3 patterns: no other associated rearrangement evidence healing at...
transmission occurs throughout the tropics and is an emerging threat in areas of
Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 phfrp3 genes make parasites undetectable by RDTs. We analyzed 19,313 public whole-genome-sequenced P. field samples to understand these better. Pfhrp2 deletion only occurred chromosomal breakage with subsequent telomere healing. Pfhrp3 involved loss from pfhrp3 the showed 3 patterns: no other associated rearrangement evidence healing at breakpoint...
Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 phfrp3 genes make parasites undetectable by RDTs. We analyzed 19,313 public whole-genome-sequenced P. field samples to understand these better. Pfhrp2 deletion only occurred chromosomal breakage with subsequent telomere healing. Pfhrp3 involved loss from pfhrp3 the showed three patterns: no other associated rearrangement evidence healing at breakpoint...