A5017847170- Renal cell carcinoma treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Testicular diseases and treatments
- Glioma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Urological Disorders and Treatments
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Adrenal and Paraganglionic Tumors
- Ocular Oncology and Treatments
- Brain Metastases and Treatment
- Cancer and Skin Lesions
- Genetic factors in colorectal cancer
- Cutaneous Melanoma Detection and Management
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- Ovarian cancer diagnosis and treatment
Lahey Medical Center
2024
Massachusetts General Hospital
2023
Mount Auburn Hospital
2021-2022
The Ohio State University
2012-2020
The Ohio State University Wexner Medical Center
2012-2020
Brown University
2019-2020
Lifespan
2019-2020
Indiana University – Purdue University Indianapolis
2017-2019
Indiana University School of Medicine
2017-2018
Washington University in St. Louis
2013-2018
Aims Renal cell carcinoma, unclassified (RCCU) is a category that includes morphologically and biologically heterogeneous group of tumours are unable to be diagnosed as other well‐defined entities. We aim describe the morphological findings within this determine most frequent features leading classification difficulty. Methods results One hundred thirty‐six cases RCCU were examined. Patients ranged in age from 23 87 years. Seventy‐seven patients men 59 women. International Society Urological...
Transcription factor E3-rearranged renal cell carcinoma (TFE3-RCC) has heterogenous morphologic and immunohistochemical (IHC) features.131 pathologists with genitourinary expertise were invited in an online survey containing 23 questions assessing their experience on TFE3-RCC diagnostic work-up.Fifty (38%) participants completed the survey. 46 of 50 reported multiple patterns, most commonly papillary pattern (almost always 9/46, 19.5%; frequently 29/46, 63%). Large epithelioid cells abundant...
Aims GATA 3 is a relatively new immunohistochemical marker which shows consistent nuclear expression in variety of tumours, including breast and urothelial carcinoma. The staining pattern adrenal lesions not well established. We aim to describe the tumours determine if there differential between pheochromocytoma cortical Methods results A retrospective search was performed identify 74 were tested immunohistochemically for expression. negative 90% In contrast, pheochromocytomas frequently...
Overgrowth of neuroglial tissue is rare in testicular germ cell tumors and mostly reported as isolated cases. We retrospectively reviewed 13 cases from 2 institutions 1995 to 2018. Hematoxylin eosin slides were collected reviewed. Immunohistochemistry was performed all with available material. The series included 4 primary 9 metastases, including 8 retroperitoneal 1 axillary lymph node (LN). average age 34 (range: 19 54). Five the LN dissections postchemotherapy, one a recurrence 5 years...
Clinical guidelines state that neoadjuvant chemotherapy should be administered before surgery in muscle invasive urinary bladder small cell neuroendocrine carcinoma. Recently described marker insulinoma-associated protein 1 (INSM1) has been reported to sensitive and specific for differentiation, however, its efficacy tract carcinoma is not well established. This study examines immunohistochemical expression of INSM1 on whole tissue sections compares with established markers....
Context.— Primitive neuroectodermal tumors (PNETs) may arise as a somatic-type malignancy in germ cell tumors. In this setting, most PNETs resemble those of the central nervous system and lack chromosome 22 translocations. However, description morphologic differentiation spectrum arising from is lacking. Objective.— To investigate immunohistochemical features these tumors, concentrating on neuronal glial features. Design.— We selected cases based morphologically identifiable and/or...
Background Utilization of fine‐needle aspiration (FNA) biopsy for the evaluation renal masses has been increasing at our institution. At times diagnostic material on direct smears is superior to that in cell block/core biopsy, therefore assigning an accurate nuclear grade cytopathology report would provide useful prognostic information. Methods Search pathology database identified FNAs performed during 11‐year period (2006–2017). Corresponding core biopsies and resections were identified....
Background Papillary renal cell carcinoma (pRCC) is classified as type 1 or 2 on the basis of histomorphologic features. Type pRCC typically carries a better prognosis, and often diagnosed by fine‐needle aspiration (FNA). Thus, this study was designed to characterize cytomorphologic features present in FNA cases that could be used discriminate between pRCC. Methods Electronic records Indiana University were searched for (2007‐2018). Corresponding surgical pathology reports reviewed classify...
Microphthalmia transcription factor (MiTF) is a sensitive and specific immunohistochemistry (IHC) marker for malignant melanoma (MM) in surgical resections, but its utility cytology specimens has not been extensively studied.A search of the pathology database identified fine-needle aspiration biopsies signed out as MM or suspicious (1998-2012). The final diagnosis IHC results were recorded, all slides re-reviewed. MiTF (C5/D5 cocktail) was performed on alcohol-fixed, Papanicolaou-stained...
Adult Wilms' tumor (WT) is a rare entity with less than 300 cases reported to date in the medical literature. Histologic and cytologic features of adult WT kidney are similar findings pediatric WT. While lungs noted be most frequent site metastatic disease population, incidence lung metastases remains unknown for A search revealed 38 published English Amongst these only two have utilized cytology lesions as means arrive at final diagnosis. We report case that was initially diagnosed using...
Adrenal cortical tumors clinically mimicking pheochromocytomas are extremely rare, with 14 cases in the literature. The authors describe 2 patients adrenal adenoma (ACA) and catecholamine elevations. impact of tissue preparation methods on electron microscopy (EM) images was assessed ACA pheochromocytoma, lacking pheochromocytoma-like symptoms. Ten were examined using EM after a variety techniques, including fixation glutaraldehyde, formalin for varying lengths time followed by and/or...
726 Background: NF2 genomic alterations (GA) have been associated with aggressive behavior in RCC. Methods: FFPE tissues from 1,386 clear cell (ccRCC), 307 papillary (pRCC), 72 chromophobe (chRCC), 145 sarcomatoid (sRCC), 54 collecting duct (cdRCC),37 medullary (medRCC) and 134 unclassified (nosRCC) underwent hybrid-capture based CGP to evaluate all classes of (GA). Tumor mutational burden (TMB) was determined on up 1.1 Mbp sequenced DNA MSI 114 loci. PD-L1 expression by IHC (Dako 22C3)....
482 Background: Plasmacytoid urothelial carcinoma (PUC) is a rare variant histology with poor prognosis. We report clinical outcomes on patients PUC. Methods: retrospectively reviewed treatments and in PUC seen at our institution from 1996 through 2016. The Kaplan-Meier method was used to calculate overall survival. Results: A total of 69 median age 68 years were identified. Five presented metastatic disease, whereas 64 diagnosed clinically localized Fifty-seven underwent radical cystectomy...
Myelodysplastic syndrome (MDS) and pulmonary tumor thrombotic microangiopathy (PTTM) are independently rare in the pediatric population. This report describes an 11-year-old male patient who initially presented with respiratory distress cardiovascular collapse. A large left main artery embolus multiple, smaller thromboemboli were widely dispersed throughout both lungs. Despite aggressive supportive care, he died within seven hours of admission. complete postmortem examination was performed,...