A5051233765- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Enhanced Recovery After Surgery
- Liver Disease Diagnosis and Treatment
- Parasitic infections in humans and animals
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Congenital Anomalies and Fetal Surgery
- Parasitic Infections and Diagnostics
- Surgical site infection prevention
- Urinary and Genital Oncology Studies
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hernia repair and management
- Cancer survivorship and care
- Liver physiology and pathology
- Lung Cancer Treatments and Mutations
- Climate Change, Adaptation, Migration
- Retinoids in leukemia and cellular processes
- Music Therapy and Health
- Acute Myeloid Leukemia Research
University Hospital of Bern
2021-2024
University of Bern
2015-2024
Sigmund Freud University Vienna
2023
Mayo Clinic
2023
Spital Zollikerberg
2023
Kantonsspital Winterthur
2016-2022
Spitäler Schaffhausen
2016-2017
Witten/Herdecke University
2016
Spontaneous ruptures of hepatocellular carcinoma (HCC) are rare. Nevertheless they may lead to difficult decisions in the emergency situation. The acute therapies include conservative treatment, transarterial embolization and surgery. Curative treatment HCC can be achieved by liver resection solely. decision-making depends on prognostic patient’s factors, such as hepatic viral infection status, Child-Pugh grade, cirrhosis number tumors. In this case was preferable a bridging therapy prior...
Clinically significant posthepatectomy liver failure (PHLF B+C) remains the main cause of mortality after major hepatic resection. This study aimed to establish an APRI+ALBI, aspartate aminotransferase platelet ratio (APRI) combined with albumin-bilirubin grade (ALBI), based multivariable model (MVM) predict PHLF and compare its performance indocyanine green clearance (ICG-R15 or ICG-PDR) albumin-ICG evaluation (ALICE).
Modern chemotherapy and repeat hepatectomy allow to tailor the surgical strategies for treatment of colorectal liver metastases (CRLM). This study addresses hypothesis that parenchymal-sparing reduces postoperative complications while ensuring similar oncologic outcomes compared standardized non-parenchymal-sparing procedures.Clinicopathological data patients who underwent resection CRLM between 2012 2019 at a hepatobiliary center in Switzerland were assessed. Patients stratified according...
A transanal total mesorectal excision (taTME) is a smart alternative to conventional TME. However, worrisome reports of high recurrence and complications triggered moratorium in few countries. This study assessed the outcomes resource utilization taTME. Consecutive patients with distal rectal cancer treated by taTME were prospectively included. Outcomes reported as median interquartile range (IQR). One hundred sixty-five (67% male 33% female) tumor 7 cm (IQR 5–10) from anal verge followed...
A key element in the postoperative phase of standardized Enhanced Recovery After Surgery (ERAS) treatment pathways is mobilization. Currently, there are no recommendations ERAS guidelines for preoperative physical activity. Patients undergoing major surgery prone to functional decline due impairment muscle, cardiorespiratory, and neurological function as a response surgical stress. It has been shown that training reduces complications. To date, limited studies investigate combined with...
IntroductionRecurrence after curative resection of hepatic alveolar echinococcosis remains a clinical challenge. The current study tested if assessment anti-recEm18 allows for postsurgical patient surveillance in patients undergoing radical echinococcosis.MethodsA retrospective with liver (n = 88) at the University Hospital Bern from 2002 to 2020 and Medical Center Ulm 2011 2017 was performed. Analysis directed determine potential association pre- postoperative values...
In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared healthy neutrophil samples. SENP5 is enzyme targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML differentiation cell models showed increased expression upon induction differentiation; contrast, knocking down...
Abstract Objective Male sex is controversially discussed as a risk factor for surgical site infections (SSI). The aim of the present study was to evaluate impact on SSI in abdominal surgery under elimination relevant confounders. Methods Clinicopathological data 6603 patients undergoing from multi-center prospective database four Swiss hospitals including between 2015 and 2018 were assessed. Patients stratified according postoperative factors identified using univariate multivariate...
Alveolar echinococcosis (AE) remains a very rare disease requiring complete radical resection for curative treatment. While open approaches are common, safety and efficacy of laparoscopic resections remain unknown.This is single-center, retrospective cohort study with patients undergoing liver hepatic AE at the Department Visceral Surgery Medicine, Bern University Hospital from December 2002 to 2020. Postoperative outcomes following hepatectomy (LH) were compared those (OH).A total 93...
In acute obstructive common bile duct (CBD) stones endoscopic retrograde cholangiography for CBD stone removal before cholecystectomy (ChE) ('ERC-first') is the gold standard of treatment. Intraoperative antegrade balloon dilatation duodenal papilla during ChE with flushing to duodenum ('ABD-during-ChE') may be an alternative 'one-stop-shop' treatment option. However, a comparison outcomes 'ABD-during-ChE' technique and the'ERC-first' approach has never been performed.
Abstract Background Transanal total mesorectal excision (taTME) is an alternative to laparoscopic and robotic TME owing its reported superior ability achieve clear margins in distal rectal cancers. Worrisome reports of high recurrence complication rates triggered a moratorium few countries. Aims This study assessed outcomes resource utilization taTME teaching hospital. Methods Patients with cancer treated by were prospectively included following ethical clearance informed consent. Outcomes...
Abstract Objective Male sex is controversially discussed as a risk factor for surgical site infections (SSI). The aim of the present study was to evaluate impact gender on SSI in abdominal surgery under elimination relevant confounders. Methods Clinicopathological data 6603 patients undergoing from multi-center prospective database four Swiss hospitals including between 2015 and 2018 were assessed. Patients stratified according postoperative factors assessed using univariate multivariate...
Fistulas in Crohn's disease are a common problem treatment of the disease.Especially perianal fistulas may cause loss patient's quality life.They coincident with an unfavourable development disease.Because frequent young age, they come along long life suffering and high cost for treatment.Therefore good clinical diagnostic balance between drug therapy surgery is needed.In this report, we present case 28-year old male patient complex system fistula disease.Based on radiological findings...
Abstract Background Best monitoring practices for patients after resection of hepatic alveolar echinococcosis remain unclear. Aims The current study tested if assessment anti-recEm18 allows postsurgical patient surveillance. Methods A retrospective with undergoing liver at the University Hospital Berne from December 2002 to 2020 and Medical Center Ulm January 2011 2017 was performed. Analysis directed determine a potential association pre- postoperative values clinical outcomes. Results...
Background: A key element in the postoperative phase of standardized Enhanced Recovery After Surgery (ERAS) treatment pathways is mobilization. Currently, there are no recommendations ERAS guidelines for preoperative physical activity. Patients undergoing major surgery prone to functional decline due impairment muscle, cardiorespiratory, and neurological function as a response surgical stress. It has been shown that training reduces complications. To date, limited studies investigate...