A5005233511- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Hormonal Regulation and Hypertension
- Advanced Energy Technologies and Civil Engineering Innovations
- Smart Materials for Construction
- Hydrogels: synthesis, properties, applications
- Concrete Corrosion and Durability
- Periodontal Regeneration and Treatments
- Diet and metabolism studies
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Education Pedagogy and Practices
- Non-Destructive Testing Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Education and Digital Technologies
- Animal testing and alternatives
- Food composition and properties
- Lipid Membrane Structure and Behavior
- Connective tissue disorders research
University of Minho
2014-2024
Institute for Biotechnology and Bioengineering
2014
Lancaster University
2009
Abstract Objectives This study aimed to improve the performance and mode of administration a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), association with dextrin-based hydrogel, DEXGEL, achieve an injectable moldable device named DEXGEL Bone. Methods Twelve participants requiring pre-molar tooth extraction implant placement were enrolled in this study. BL® granules (250–500 µm) administered 6 randomized whereas other received After months, biopsy...
Os jogos e brincadeiras desempenham um papel fundamental no ambiente escolar, proporcionando espaço lúdico que favorece o aprendizado desenvolvimento integral dos alunos. Ao integrar atividades lúdicas cotidiano os educadores promovem mais dinâmico interativo, onde as crianças podem explorar conceitos de forma criativa. Essas não apenas estimulam a socialização cooperação entre alunos, mas também desenvolvem habilidades cognitivas, motoras emocionais. Por meio jogos, estudantes aprendem...
Abstract A local drug delivery system that attempts to find a suitable balance between antimicrobial and regenerative actions was developed for osteomyelitis treatment (OM). This combines the angiogenic immunomodulatory peptide LLKKK18 (LL18) vancomycin hydrochloride (VH), loaded into an injectable oxidized dextrin (ODEX)‐based hydrogel (HG). In vitro cytotoxicity analyzed in MC3T3‐E1 pre‐osteoblasts erythrocytes. The kinetics of LL18 release studied. Antimicrobial activity assessed against...
Increasing relevance has been attributed to hydrogels due their ability provide an extracellular matrix (ECM)-like environment for cellular adhesion and proliferation, acting as mechanical scaffolds tissue remodeling or delivery matrices. In vivo biocompatibility of a hybrid dextrin hydrogel produced from oxidized adipic acid dihydrazide its combinations with human mesenchymal stem cells (hMSCs), ECM porcine bladder (urinary matrix) ceramic granules (Bonelike®), was evaluated following ISO...
The worldwide incidence of bone disorders is raising, mainly due to aging population. lack effective treatments pushing the development synthetic substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Attempting solve these issues and achieve wider acceptance by clinicians, granular ceramics have been associated with hydrogels (HGs) produce injectable/moldable SBSs. Dextrin, a low-molecular-weight carbohydrate, was used develop fully...
Abstract The development of injectable bone substitutes (IBS) have obtained great importance in the regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able fit irregular topographies. In this scenario, association hydrogels graft granules is emerging well-established trend. Particularly, situ forming arisen new IBS generation. An dextrin-based hydrogel (HG) was developed, aiming act carrier granular bioactive agents. work, HG...
Abstract Hydrogels are three‐dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount water or biological fluids, without dissolving. Dextrin, low‐molecular‐weight carbohydrate composed by glucose residues, has been used to develop an injectable hydrogel for biomedical applications. Dextrin was first oxidized introduce aldehyde groups, which then reticulate adipic acid dihydrazide, forming the dextrin‐based (HG). The HG and its components were tested cyto‐...
Conductive cement-based materials have attracted particular attention due to their potential enable low-cost continuous monitoring of next-generation smart structures. This feature is relevant in highly energetic marine environments, where structural damage excessive loads and remote locations are critical the performance However, best authors knowledge literature exploring this context environment inexistent. To fill gap, an electrically conductive cementitious composite (E3C) was developed...
Regeneration of severe bone defects remains a challenge. A formulation synthetic glass-reinforced hydroxyapatite substitute, Bonelike® Poro (BL®P), 250 - 500 µm-diameter, with dextrin-based hydrogel (HG), further loaded human dental pulp stem cells (hDPSCs) osteogenic differentiation ability, was tested for the management critical-sized in an ovine model. Morphology, calcium release, and mechanical strength HG + BL®P were analyzed. Then, BL®P, 106 hDPSCs-loaded implanted 14 mm-diameter...
<p>Self-monitoring structural materials have recently raised renovated attention due to their potential enable continuous low-cost monitoring of next-generation smart-structures. This characteristic is particularly important in harsh environments such as highly energetic marine coastal areas, where damage excessive loading frequent and very impactful the performance structures. In context this research a sustainable fiber reinforced conductive concrete was developed studied, with aim...