A5030100323- Cytomegalovirus and herpesvirus research
- Lipid Membrane Structure and Behavior
- Food Chemistry and Fat Analysis
- Proteins in Food Systems
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Immune Cell Function and Interaction
- Drug-Induced Hepatotoxicity and Protection
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Reproductive System and Pregnancy
- Drug Transport and Resistance Mechanisms
Huntsman Cancer Institute
2019
University of Utah
2019
Massachusetts General Hospital
1998
Harvard University
1998
US11 and US2 encode gene products expressed early in the replicative cycle of human cytomegalovirus (HCMV), which cause dislocation murine major histocompatibility complex (MHC) class I molecules from lumen endoplasmic reticulum to cytosol, where heavy chains are rapidly degraded. Human leukocyte antigens (HLA)-C HLA-G uniquely resistant effects both a trophoblast cell line as well porcine endothelial cells stably transfected with genes. Dislocation degradation MHC do not appear involve...
Abstract Mammalian mitochondrial DNA (mtDNA) is replicated by polymerase γ (POLγ), a heterotrimeric complex consisting of catalytic POLγA subunit and two accessory POLγB subunits 1 . More than 300 mutations in POLG , the gene encoding subunit, have been linked to severe, progressive conditions with high rates morbidity mortality, for which no treatment exists 2 Here we report on discovery characterization PZL-A, first-in-class small-molecule activator mtDNA synthesis that capable restoring...
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated stabilize β-catenin protein, leading nuclear and/or cytoplasmic localization and downstream activation Wnt target genes. In patient HCC samples, are typically patchy, even among with highly active mutations. The functional clinical relevance this heterogeneity not well understood. To define mechanisms β-catenin-driven initiation, we generated a Cre-lox system...
With the goal of refining our discovery DMPK workflow, we conducted a retrospective analysis on internal Celgene compounds by calculating physicochemical properties and gathering data from several assays including solubility, rat human liver S9 stability, Caco-2 permeability, intravenous (iv.) oral pharmacokinetics. Our identified plasma clearance to be most statistically relevant for prediction exposure. In rat, with stability ≥70% at 60 min ≤43 ml/min/kg had greatest chance achieving...