A5007694645- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Gene expression and cancer classification
- CNS Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Gene Regulatory Network Analysis
- Parvovirus B19 Infection Studies
- Genetic factors in colorectal cancer
- Multiple Myeloma Research and Treatments
- Maritime Security and History
- Bioinformatics and Genomic Networks
- Chronic Myeloid Leukemia Treatments
- Rice Cultivation and Yield Improvement
- Genomic variations and chromosomal abnormalities
- Metabolomics and Mass Spectrometry Studies
Mayo Clinic Hospital
2021
Huntsman Cancer Institute
2018-2020
University of Utah
2018-2020
St Christopher's Hospice
2019
University of Minnesota
2019
University of California, Davis
2013-2018
Mayo Clinic in Arizona
2016-2017
Mayo Clinic in Florida
2012-2015
WinnMed
2012-2015
Brigham Young University
2014
During wheat senescence, leaf components are degraded in a coordinated manner, releasing amino acids and micronutrients which subsequently transported to the developing grain. We have previously shown that simultaneous downregulation of Grain Protein Content (GPC) transcription factors, GPC1 GPC2, greatly delays senescence disrupts nutrient remobilization, therefore provide valuable entry point identify genes involved micronutrient transport generated loss-of-function mutations for GPC2...
Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in health disease. During the analysis of scRNAseq data, annotating biological identity clusters is an important step before downstream analyses it remains technically challenging. The current solutions for single generally lack a graphical user interface, can be computationally intensive or have limited scope. On other hand, manually by examining expression marker genes...
Abstract Purpose: Clear cell renal carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a promoting role for HIF-2α, suppressor HIF-1α. However, few studies have comprehensively examined clinical relevance this paradigm. Furthermore, hypoxia-associated factor (HAF), which regulates HIFs, has not been evaluated ccRCC....
Abstract Motivation: Isotope trace (IT) detection is a fundamental step for liquid or gas chromatography mass spectrometry (XC-MS) data analysis that faces multitude of technical challenges on complex samples. The Kalman filter (KF) application to IT addresses some these challenges; it discriminates closely eluting ITs in the m/z dimension, flexibly handles heteroscedastic variances and does not bin axis. Yet, behavior this KF has been fully characterized, as no cost-free open-source...
Abstract Patients with indolent non‐Hodgkin lymphoma (NHL) have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted assess feasibility, efficacy, and safety of adding lenalidomide rituximab, cyclophosphamide, dexamethasone (LR‐CD) untreated NHL patients requiring a institution phase II trial. Treatment consisted IV rituximab 375 mg/m 2 day 1; oral...
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated stabilize β-catenin protein, leading nuclear and/or cytoplasmic localization and downstream activation Wnt target genes. In patient HCC samples, are typically patchy, even among with highly active mutations. The functional clinical relevance this heterogeneity not well understood. To define mechanisms β-catenin-driven initiation, we generated a Cre-lox system...
Challenges with distinguishing circulating tumor DNA (ctDNA) from next-generation sequencing (NGS) artifacts limits variant searches to established solid mutations. Here we show early and random PCR errors are a principal source of NGS noise that persist despite duplex molecular barcoding, removal due clonal hematopoiesis indeterminate potential, suppression patterned errors. We also demonstrate sample duplicates necessary eliminate the stochastic associated NGS. Integration into analytics...
Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH recognized to occur adults, often associated hematologic malignancies or serious infections.Patients are critically ill, rapid diagnosis is key. In the search for trigger must begin promptly as time effects survival. The underlying our Histoplasma capsulatum infection, which rare southwestern United States. Prompt led...
Abstract Purpose We previously reported an interaction with warfarin anticoagulation when initiating treatment direct-acting antiviral agents for hepatitis C infection. A decreased sensitivity led to subtherapeutic anticoagulation. To study this further, we expanded our research include patients treated the combination of elbasvir and grazoprevir concurrent investigated changes in during after treatment. Methods Using electronic health records Veterans Health Administration, starting...
The life expectancy of patients with chronic phase myeloid leukemia on tyrosine kinase inhibitor therapy now approaches that the general population. Approximately 60% treated second generation inhibitors achieve a deep molecular response, prerequisite for trial treatment-free remission. Those unlikely to response may benefit from more intensive up front. To identify biomarkers predicting we performed transcriptional profiling CD34+ progenitor cells newly diagnosed nilotinib prospective...
Introduction: Lymphoepithelial cysts(LEC) of the pancreas are benign, rare pancreatic cysts that found predominantly in men. These can present as a diagnostic conundrum given their rarity and difficulty distinguishing from with neoplastic potential. We an incidental case LEC middle-aged man. Case description: A 56-year-old gentleman presented for evaluation cyst had been incidentally on Computed tomography (CT) scan during myasthenia gravis. He denied abdominal pain, weight loss, history...
<p>Additional methods</p>
<p>Supplemental Figure Legends</p>
<p>Supplemental Figures</p>
<p>Supplemental Figure Legends</p>
<div>AbstractPurpose:<p>Clear cell renal carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a promoting role for HIF-2α, suppressor HIF-1α. However, few studies have comprehensively examined clinical relevance this paradigm. Furthermore, hypoxia-associated factor (HAF), which regulates HIFs, has not been...
<div>AbstractPurpose:<p>Clear cell renal carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a promoting role for HIF-2α, suppressor HIF-1α. However, few studies have comprehensively examined clinical relevance this paradigm. Furthermore, hypoxia-associated factor (HAF), which regulates HIFs, has not been...
<p>Supplemental Tables</p>
<p>Supplemental Figures</p>
<p>Additional methods</p>
<p>Supplemental Tables</p>