A5030458655- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Caveolin-1 and cellular processes
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Plant nutrient uptake and metabolism
- Hippo pathway signaling and YAP/TAZ
- Ocean Waves and Remote Sensing
- PI3K/AKT/mTOR signaling in cancer
- Arsenic contamination and mitigation
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Legume Nitrogen Fixing Symbiosis
- Tropical and Extratropical Cyclones Research
- Studies on Chitinases and Chitosanases
- Cancer-related gene regulation
- Climate variability and models
- Cancer-related Molecular Pathways
National Taiwan University
2011-2024
National Cheng Kung University
2023-2024
National Chung Hsing University
2023-2024
Taichung Veterans General Hospital
2024
Institute of Biomedical Sciences, Academia Sinica
2012-2023
National Yang Ming Chiao Tung University
2014-2023
National Chengchi University
2005-2022
Rogers (United States)
2021
University of Wisconsin–Madison
2021
University of California, Irvine
2021
The tensin family member cten (C-terminal like) is an Src homology 2 (SH2) and phosphotyrosine binding domain–containing focal adhesion molecule that may function as a tumor suppressor. However, the mechanism has not been well established. We report binds to another suppressor, deleted in liver cancer 1 (DLC-1), SH2 domain of responsible for interaction. Unexpectedly, interaction between DLC-1 independent tyrosine phosphorylation DLC-1. By site-directed mutagenesis, we have identified...
Abstract This paper describes the methodology of an ongoing project constructing East Asian climate database REACHES based on Chinese historical documents. The record source is Compendium Meteorological Records China in Last 3000 Years which collects meteorology and related records from mainly official local chronicles along with a small number other We report digitization covering period 1644–1795. An example original translated to illustrate typical contents contain time, location type...
Abstract C-terminal tensin-like (cten) is a focal adhesion molecule belonging to the tensin family. Previous studies have suggested that cten may function as prostate-specific tumor suppressor. Here, we show although expressed at very low level in normal colon, its expression significantly up-regulated colon cancer. Furthermore, high population of found nucleus, where it interacts with β-catenin, critical player canonical Wnt pathway. This interaction contribute role enhancing colony...
Quiescent cancer stem cells (CSCs) have long been considered to be a source of tumor initiation. However, identification and isolation these hampered by the fact that commonly used fluorescent markers are not sufficiently stable, both chemically photophysically, allow tracking over an extended period time. Here, it is shown nanodiamonds (FNDs) well suited for this application. Genotoxicity tests FNDs with comet micronucleus assays human fibroblasts breast indicate nanoparticles neither cause...
Chinese olive (Canarium album L.) has been highlighted for its remarkable health benefits. We previously showed that the ethyl acetate fraction of (COE) is an effective anti-inflammatory agent. In this study, we used a luciferase-based RAW 264.7 cell platform to detect transcriptional activity NF-κB, key mediator inflammation, and promoter downstream target, COX-2. Through functional-oriented screening using these platforms, further divided COE into several subfractions. Subsequently, silica...
Abstract Here, we report the identification of a new tensin family member, tensin3, and its role in epidermal growth factor (EGF) signaling pathway. Human tensin3 cDNA encodes 1445 amino acid sequence that shares extensive homology with tensin1, tensin2, COOH-terminal tensin-like protein. Tensin3 is expressed various tissues different cell types such as endothelia, epithelia, fibroblasts. The potential EGF-induced pathway explored. EGF induces tyrosine phosphorylation MDA-MB-468 cells time-...
Abstract Deleted in liver cancer-1 (DLC-1) is a RhoGTPase-activating protein (RhoGAP) domain containing tumor suppressor that often down-regulated various cancer types. Previously, we have shown DLC-1 recruited to focal adhesions by binding the Src homology 2 domains of tensins and adhesion localization critical for suppression activity DLC-1. To investigate whether mutations targeting (FAT) region might occur attenuate expression, localization, function DLC-1, first mapped FAT amino acid...
Metabolic syndrome (MetS), characterized by a constellation of disorders such as hyperglycemia, insulin resistance, and hypertension, is becoming major global public health problem. Fructose consumption has increased dramatically over the past several decades with it incidence MetS. However, its molecular mechanisms remain to be explored. In this study, we used male Sprague-Dawley (SD) rats study pathological mechanism fructose induced The SD were fed 60% high-fructose diet for 16 weeks...
Abstract Devastating Japan in October 2019, Supertyphoon (STY) Hagibis was an important typhoon the history of Pacific. A striking feature its explosive rapid intensification (RI). In 24 h, intensified by 100 knots (kt; 1 kt ≈ 0.51 m s −1 ), making it one fastest-intensifying typhoons ever observed. After RI, Hagibis’s stalled. Using current intensity record holder, i.e., STY Haiyan (2013), as a benchmark, this work explores evolution differences these two high-impact STYs. We found that...
A monoclonal antibody (mAb) specific to domoic acid was produced from a stable hybridoma cell line, 9F1F11, generated by the fusion of P3/NS1/1-AG4-1 myeloma cells with spleen isolated Balb/c mouse immunized acid−keyhole limpet hemocyanin. The 9F1F11 mAb belongs immunoglobulin G1 (κ-chain) isotype. competitive direct enzyme-linked immunosorbent assay (cdELISA) and indirect ELISA were established for characterization. In cdELISA, concentration causing 50% inhibition (IC50) binding...
We examine the effectiveness of mandatory audit-partner rotation in promoting audit quality using data Taiwan where a five-year became de facto 2004. Using both absolute and signed abnormal accruals working capital as proxies for quality, we find some evidence that companies subject to 2004 is higher than not However, lower these same 2003 under old partners. Furthermore, indistinguishable from whose partners were voluntarily rotated before 2003. Therefore, effect on terms auditors...
The Rho GTPase-activating protein DLC1 is a tumor suppressor that often deleted in liver cancer and downregulated other cancers. regulates the actin cytoskeleton, cell shape, adhesion, migration, proliferation through its activity focal adhesion localization. In this study, we silenced nonmalignant prostate epithelial cells to explore suppression functions. Small hairpin RNA-mediated silencing of was insufficient promote more aggressive phenotypes associated with growth. contrast, promoted...
The anti-proliferation and anti-tumor effects on cancer cells mediated by MEO is due to inhibition of the NF-κB pathway.
Abstract TIAM Rac1-associated GEF 2 short-form protein (TIAM2S) is abundant in specific brain tissues, especially the hippocampus, a region critical for processing and consolidation of spatial memory. However, how TIAM2S plasticizes microstructure circuits hippocampus to shape memory as neuroplastic regulator during aging remains be determined. In this study, transgenic mice overexpressing human (TIAM2S-TG mice) were included, interdisciplinary approaches, such tests multiparametric magnetic...
A class III chitinase cDNA (BoChi3-1) was cloned using a library from suspension-cultured bamboo (Bambusa oldhamii) cells and then transformed into yeast (Pichia pastoris X-33) for expression. Two recombinant chitinases with molecular masses of 28.3 35.7 kDa, respectively, were purified the yeast's culture broth to electrophoretic homogeneity sequential ammonium sulfate fractionation, Phenyl-Sepharose hydrophobic interaction chromatography, Con A-Sepharose chromatography steps. N-Terminal...