A5052519791- Psoriasis: Treatment and Pathogenesis
- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Nail Diseases and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Autoimmune Bullous Skin Diseases
- Innovation and Knowledge Management
- Health Systems, Economic Evaluations, Quality of Life
- Regional Development and Policy
- Cultural Industries and Urban Development
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Nonmelanoma Skin Cancer Studies
- Business Strategy and Innovation
- Pharmaceutical studies and practices
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- University-Industry-Government Innovation Models
- Public Health Policies and Education
- Antioxidant Activity and Oxidative Stress
- Simulation Techniques and Applications
- Dermatological and Skeletal Disorders
- Public Administration, ICT, and Policy Development
- Nasolacrimal Duct Obstruction Treatments
George Washington University
2013-2025
American Academy of Dermatology
2022
Manchester Metropolitan University
2011-2019
McGill University Health Centre
2017
Birmingham City University
2015-2016
University of Birmingham
2014
Institute of Art
2014
University of California, San Francisco
2013
Digital Research Alliance of Canada
2002-2008
Langley Research Center
2008
Background The topical phosphodiesterase 4 inhibitor roflumilast has been studied in several dermatologic conditions. Objective Roflumilast foam 0.3% is being investigated as a treatment for seborrheic dermatitis (SD). Methods In this phase 3, double-blinded trial, patients with SD were randomly assigned (2:1 ratio) to once-daily or vehicle 8 weeks. primary efficacy outcome was Investigator Global Assessment (IGA) Success at week 8, defined IGA of 0 (Clear) 1 (Almost Clear) plus ≥2-point...
Re‐examines traditional views on change management, in particular the resistance to change, and suggest alternative a practical approach for better managing change. The literature management contains numerous prerequisites successful with predominantly negative view issue of Some authors have argued positive utility resistance, but lamented lack theories which support this view. Describes methodology called theory constraints (TOC) as necessary force, we demonstrate how it was applied case...
Carotid endarterectomy is an effective method for preventing strokes if patients do not suffer adverse perioperative outcomes. The purpose of this study was to identify preoperative patient risk factors outcomes (death or nonfatal stroke) after carotid through the use a large population-based registry from Ontario, Canada.Medical records all 6038 who underwent in Ontario between January 1, 1994, and December 31, 1997, were abstracted 34 hospitals. Patient characteristics (demographic data,...
Glycopyrronium tosylate (GT) is a topical anticholinergic developed for once-daily treatment of primary axillary hyperhidrosis.Assess the efficacy and safety GT hyperhidrosis.ATMOS-1 ATMOS-2 were replicate randomized, double-blind, vehicle-controlled, 4-week phase 3 trials. Patients randomized 2:1 to 3.75% or vehicle applied once daily each axilla 4 weeks. Coprimary endpoints responder rate (≥4-point improvement from baseline) on item 2 (severity sweating) Axillary Sweating Daily Diary...
Background: The American Academy of Dermatology recommends combination treatment for most patients with acne, but adding ingredients to a regimen may increase the risk adverse effects. Clindamycin phosphate 1.2%/adapalene (ADAP) 0.15%/benzoyl peroxide (BPO) 3.1% (CAB) gel is only triple-combination fixed-dose topical formulation acne. In clinical studies, CAB demonstrated superior efficacy vehicle and component dyad gels, good safety/tolerability. Objectives: Document journey trial...
Introduction Objective response rate (ORR), defined as the percentage of patients achieving a complete or partial to treatment, is critical endpoint in clinical trials assessing efficacy new therapies solid tumors, including BCC. We performed post-hoc analysis exploring ORR potential primary for future studies evaluating VP-315, an intratumorally injected, chemotherapeutic oncolytic peptide. To evaluate effect various VP-315 8 mg dosing regimens on antitumor subjects with Methods Eighty-two...
Glycopyrronium tosylate is a topical anticholinergic approved in the USA for primary axillary hyperhidrosis patients aged ≥ 9 years (Qbrexza™ [glycopyrronium] cloth, 2.4%). This 44-week open-label extension study assessed glycopyrronium safety and descriptive efficacy completing one of two, phase III, double-blind, vehicle-controlled, 4-week trials (NCT02530281; NCT02530294). Patients with were randomized 2:1 (glycopyrronium tosylate: vehicle, once daily) double-blind trials. Completers...
New, effective, and well-tolerated oral therapies are needed for treating psoriasis. Zasocitinib, a highly selective allosteric tyrosine kinase 2 (TYK2) inhibitor, is potential new treatment this disease.
Abstract We studied electroencephalograms and computed tomographic scans of 54 patients with acute hemispheric strokes. Electrographic parameters evaluated included field, amplitude, frequency, persistence, reactivity focal or lateralized slow‐wave activity. Ipsilateral contralateral background activity were also assessed. Structural clinical features lesion size, density, mass effect, location, tissue involvement, deep structure level consciousness, outcome. The data analyzed using computer...
Primary care physician (PCP) perceptions regarding expertise in cutaneous surgery and cosmetic procedures are unknown.An internet-based survey was administered to physicians primary medicine residency programs the United States. Respondents were asked select specialist most qualified perform different surgical procedures.Five hundred sixty-one PCPs undertook survey. Dermatologists identified as evaluate biopsy worrisome lesions on face (95%), skin cancer (56%), inject botulinum toxin (61%),...
Hyperhidrosis in pediatric patients has been understudied. Post hoc analyses of two phase 3 randomized, vehicle-controlled, 4-week trials (ATMOS-1 [NCT02530281] and ATMOS-2 [NCT02530294]) were performed to assess efficacy safety topical anticholinergic glycopyrronium tosylate (GT) patients.Patients had primary axillary hyperhidrosis ≥ 6 months, average Axillary Sweating Daily Diary (ASDD/ASDD-Children [ASDD-C]) Item 2 (sweating severity) score 4, sweat production 50 mg/5 min (each axilla),...
When assessing the effect of a therapy for psoriasis (PsO), it is important to consider speed response and cumulative response. However, responses among biologics may differ by body regions. This post hoc analysis compares ixekizumab (IXE), an interleukin-17A antagonist, guselkumab (GUS), interleukin-23p19 inhibitor, in different regions patients with moderate-to-severe plaque PsO participating IXORA-R study, up week 24. The design has been previously described. Patients received respective...