A5066616903- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Autoimmune Bullous Skin Diseases
- Advancements in Transdermal Drug Delivery
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Dermatological diseases and infestations
- Body Image and Dysmorphia Studies
- Herpesvirus Infections and Treatments
- Drug-Induced Adverse Reactions
- melanin and skin pigmentation
- Plant-based Medicinal Research
- Antifungal resistance and susceptibility
- Botulinum Toxin and Related Neurological Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Photodynamic Therapy Research Studies
- Phytochemistry Medicinal Plant Applications
- Bee Products Chemical Analysis
- Retinoids in leukemia and cellular processes
Houston Institute for Clinical Research
2017-2025
Sanova (United States)
2020-2024
Texas Retina Associates (United States)
2022-2024
Pflugerville Independent School District
2021-2024
Cornell University
2024
Instrumental Polymer Technologies (United States)
2023
Center for Clinical Research (United States)
2022
Arlington Center for Dermatology
2021
Baylor University Medical Center
2021
Pflüger (Germany)
2021
The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, precursor of squamous-cell carcinoma.
Background The topical phosphodiesterase 4 inhibitor roflumilast has been studied in several dermatologic conditions. Objective Roflumilast foam 0.3% is being investigated as a treatment for seborrheic dermatitis (SD). Methods In this phase 3, double-blinded trial, patients with SD were randomly assigned (2:1 ratio) to once-daily or vehicle 8 weeks. primary efficacy outcome was Investigator Global Assessment (IGA) Success at week 8, defined IGA of 0 (Clear) 1 (Almost Clear) plus ≥2-point...
Current topical treatment options for seborrheic dermatitis are limited by efficacy and/or safety.To assess safety and of roflumilast foam, 0.3%, in adult patients with affecting the scalp, face, trunk.This multicenter (24 sites US Canada) phase 2a, parallel group, double-blind, vehicle-controlled clinical trial was conducted between November 12, 2019, August 21, 2020. Participants were (aged ≥18 years) a diagnosis 3-month or longer duration Investigator Global Assessment (IGA) score 3...
We evaluated the efficacy of brodalumab in patients with nail or scalp psoriasis three phase 3 studies (AMAGINE-1/-2/-3).In AMAGINE-1, clearance, measured by severity index (PSSI), was reported for who received 210 mg every 2 weeks (Q2W) placebo through 12 weeks. In AMAGINE-2/-3, (NAPSI), receiving either Q2W ustekinumab continuously 52 weeks.At week 12, significantly more achieved 75% and 100% improvement rates from baseline PSSI had lower mean across compared placebo, significant evident...
Acne affects more than 80% of adolescents and young adults, who most often develop acne scars. Supporting data on the effect scars patient's health-related quality life (HRQOL) are limited. The aim was to determine how severity impacts HRQOL afflicted individuals. In this population-based cross-sectional study, 723 adults with facial but without active lesions self-completed Self-assessment Clinical Acne-Related Scars (SCARS) questionnaire formulated investigate degree scarring. Facial Scar...
Baricitinib, a selective Janus kinase 1/Janus 2 inhibitor, is indicated in the European Union and Japan for treatment of moderate-to-severe atopic dermatitis (AD) adults who are candidates systemic therapy. The objective this study was to evaluate safety baricitinib mg AD clinical program. Six double-blind, randomized, placebo-controlled studies, two long-term extension studies were summarized datasets. Placebo comparison based on six 16-week with mg. All-bari-2-mg-AD included patients...
Acne confers an increased risk of physical, psychiatric, and psychosocial sequelae, potentially affecting multiple dimensions health-related quality life (HRQoL). Morbidity associated with truncal acne is poorly understood.To determine how severity location lesions impact the HRQoL those who suffer from it.A total 694 subjects combined facial (F+T) 615 only (F) participated in online, international survey. Participants self-graded their at different anatomical locations completed dermatology...
Background: Injection site reactions are well recognized in patients treated with etanercept.Previous reports describe histologic findings of a cell-mediated T H 1 reaction, CD8 ϩ cells composing the majority dermal infiltrate.Observations: A pruritic, erythematous, edematous patch occurred on right thigh 57-year-old white woman for rheumatoid arthritis within 12 to 24 hours after her second dose subcutaneous etanercept.The patient had similar reaction adalimumab injection 2 weeks prior...
FMX101 4% topical minocycline foam has been shown to be an effective and safe treatment for acne vulgaris (AV).To further evaluate the efficacy safety of in treating moderate severe vulgaris.A 12-week, multicenter, randomized (1:1), double-blind, vehicle-controlled study was conducted. Coprimary end points were absolute change inflammatory lesion count from baseline rate success (Investigator's Global Assessment score 0 or 1 with a ≥2-grade improvement).There 1488 participants...
A three-pronged approach to acne treatment—combining an antibiotic, antibacterial, and retinoid—could provide greater efficacy tolerability than single or dyad treatments, while potentially improving patient compliance reducing antibiotic resistance. We aimed evaluate the safety of triple-combination, fixed-dose topical clindamycin phosphate 1.2%/benzoyl peroxide (BPO) 3.1%/adapalene 0.15% (IDP-126) gel for treatment acne. In a phase II, double-blind, multicenter, randomized, 12-week study,...
Scalp psoriasis affects most patients with psoriasis, but it can be difficult to treat.To evaluate the efficacy and safety of once-daily roflumilast foam 0.3% on scalp body psoriasis.In a phase IIb randomized controlled trial, adults adolescents aged ≥ 12 years were (2 : 1) or vehicle for 8 weeks. The primary endpoint was Investigator Global Assessment (S-IGA) success (score 'clear' 'almost clear' plus 2-grade improvement from baseline) at week 8. Safety tolerability also...
BackgroundA three-pronged acne treatment approach—combining an antibiotic, antibacterial agent, and retinoid—may provide greater efficacy than single/double treatments. Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide (BPO) 3.1% gel (IDP-126) is the first fixed-dose triple-combination in development for acne.ObjectiveTo confirm efficacy, safety, tolerability of IDP-126 treatment.MethodsTwo phase 3, double-blind, 12-week studies randomized participants aged ≥9 years with...
Abstract Background OnabotulinumtoxinA 20 U reduces glabellar line (GL) severity at maximum frown for approximately 3 to 4 months. Small studies have suggested that >20-U doses may increase the efficacy and duration of response GLs. Objectives The aim this study was evaluate safety, pharmacodynamic response, treatment satisfaction with onabotulinumtoxinA ≥20 Methods This 48-week, double-blind compared 40, 60, 80 vs placebo in women moderate or severe dynamic GLs on Allergan Facial...
Introduction: Hyaluronic acid (HA) is a unique molecule with multiple biological activities. In skin, HA plays an essential role as humectant, capable of binding up to 1000 times its mass water, leading both skin moisturization and extracellular matrix rigidity. concentration synthesis decreases significantly in aging due exogenous endogenous factors, including photoaging metabolism, respectively. A key driver for degradation decrease mediated via the induction reactive oxygen species (ROS)...
Introduction: Hyaluronic acid (HA) has become a commonly used ingredient in many topical moisturizing products due to its strong humectant properties and essential role skin hydration; however, limitations of delivery HA only the surface hindered leveraging full capacity biology necessary for rejuvenation. Here we describe clinical efficacy data set novel next-generation, multi-weight plus antioxidant complex-based formulations with targeted enhance rejuvenation, giving youthful, healthy...
Meibomian glands are modified oil-producing that produce meibum and can become dysfunctional negatively affect the lipid layer in tear film, resulting ocular surface diseases such as evaporative dry eye. Abnormal keratin production aggregation at meibomian gland orifice has been implicated pathogenesis of dysfunction (MGD). Current treatments largely ignore role proteins. This review paper synthesizes various publications on hyperkeratinization its MGD proposes a novel treatment strategy for...
Abstract Background/Objectives Topical clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel (IDP‐126) is the first fixed‐dose triple‐combination formulation in development for acne. This post hoc analysis investigated efficacy and safety of IDP‐126 children adolescents with moderate‐to‐severe Methods In a randomized, double‐blind phase 2 study (NCT03170388), participants ≥9 years age acne were eligible randomization (1:1:1:1:1) to once‐daily IDP‐126, one three dyad...
Background: The most rapidly increasing medical aesthetic procedures for facial antiaging comprise nonenergy and injectable treatments. Currently, standards skin care before, during, after treatments are lacking. algorithm on supportive aims to stimulate healing, reduce downtime, improve comfort treatment outcomes.