A5103144212- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Glaucoma and retinal disorders
- Hair Growth and Disorders
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Allergic Rhinitis and Sensitization
- Reproductive Biology and Fertility
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Genetic and rare skin diseases.
- Nonmelanoma Skin Cancer Studies
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Neonatal skin health care
- Plant Pathogens and Fungal Diseases
- Antifungal resistance and susceptibility
- Pluripotent Stem Cells Research
- Retinal Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
Atara Biotherapeutics (United States)
2023-2025
La Jolla Alcohol Research
2023
Qingdao Agricultural University
2022
Chinese University of Hong Kong
2018-2021
Scripps Clinic Medical Group
2012
Children's Hospital of Philadelphia
2011
Baylor College of Medicine
2009
Rockefeller University
2006-2008
New York University
2003-2008
Howard Hughes Medical Institute
1996-2008
Background The topical phosphodiesterase 4 inhibitor roflumilast has been studied in several dermatologic conditions. Objective Roflumilast foam 0.3% is being investigated as a treatment for seborrheic dermatitis (SD). Methods In this phase 3, double-blinded trial, patients with SD were randomly assigned (2:1 ratio) to once-daily or vehicle 8 weeks. primary efficacy outcome was Investigator Global Assessment (IGA) Success at week 8, defined IGA of 0 (Clear) 1 (Almost Clear) plus ≥2-point...
We have identified the palmitoylated cysteine residues of alpha q and s, subunits two heterotrimeric G proteins. Mutational substitutions serines for cysteines 9 10 in 3 s profoundly alter behavior expressed HEK293 cells. Neither mutant subunit incorporates palmitate; both proteins are found soluble rather than particulate fraction; or cannot couple a co-expressed receptor to stimulation phospholipase C adenylylcyclase, respectively; substitution prevents mutationally activated (R183C) from...
Importance Safe, effective, and well-tolerated topical treatment options available for long-term use in patients with atopic dermatitis (AD) are limited associated low adherence rates. Objective To evaluate efficacy safety of once-daily roflumilast cream, 0.15%, vs vehicle cream AD. Design, Setting, Participants Two phase 3, randomized, double-blind, vehicle-controlled trials (Interventional Trial Evaluating Roflumilast Cream the Treatment Atopic Dermatitis 1 2 [INTEGUMENT-1 INTEGUMENT-2]),...
The Syk/ZAP-70 family of protein tyrosine kinases is indispensable for normal lymphoid development. Syk necessary the development B cells and epithelial gammadelta T cells, whereas ZAP-70 essential TCR signaling. In this study, we show that although alphabeta lineage was arrested in thymus, CD3-positive primarily lineage, were present lymph nodes mice lacking ZAP-70. Moreover, absence ZAP-70, dendritic epidermal fewer number abnormal morphology, intestinal intraepithelial lymphocytes,...
To compare visual field defects obtained with both multifocal evoked potential (mfVEP) and Humphrey (HVF) techniques to topographic optic disc measurements in patients normal tension glaucoma (NTG) high (HTG).We studied 32 NTG HTG. All had reliable 24-2 HVFs a mean deviation of -10 dB or better, glaucomatous an abnormal HVF at least 1 eye. Multifocal VEPs were from each eye probability plots created. The mfVEP divided into central 10-degree radius outer arcuate subfield superior inferior...
ABSTRACT Background/Objectives Efficacy and safety of roflumilast cream 0.15% were demonstrated in patients aged ≥ 6 years with atopic dermatitis (AD) two Phase 3 trials. This parallel‐group, double‐blind trial (INTEGUMENT‐PED; NCT04845620) compared the efficacy 0.05% a vehicle 2–5 AD. Methods Patients mild‐to‐moderate AD treated once‐daily or for 4 weeks. The primary endpoint was Validated Investigator Global Assessment (vIGA‐AD) Success (0 [Clear] 1 [Almost Clear] plus 2‐grade improvement...
Introduction Seborrheic dermatitis (SD) affects a large, diverse population and is associated with significant morbidity/burden.
AP-2 transcription factors have been implicated in epidermal biology, but their functional significance has remained elusive. Using conditional knockout technology, we show that AP-2α is essential for governing the balance between growth and differentiation epidermis. In vivo, epidermis lacking exhibits elevated expression of factor receptor (EGFR) differentiating layers, resulting hyperproliferation when receptors are activated. Chromatin immunoprecipitation promoter activity assays...
Toehold switches are a class of RNAs with hairpin loop that can be unfolded upon binding trigger RNA, thereby exposing ribosome site (RBS) and permitting translation the reporter protein. They have been shown very useful in detecting variety targets including from Zika Ebola viruses. The base complementation between toehold switch RNA also makes it sensitive to sequence variations. Design involves series considerations related their properties, structures specificities.Here we present first...
Seborrheic dermatitis (SD) is a common, chronic inflammatory skin disease, but the physical and emotional burden of patients with SD experience has not been well characterized. The Harris Poll conducted online surveys US healthcare providers (HCPs) from December 2021 to January 2022. Almost half reported that negatively impacts their well-being "a lot/a great deal"; HCPs underestimate level impact on patients. Most significant mental health impact, including anxiety, depression, anxiety...
Thymocyte development proceeds through two critical checkpoints that involve signaling events different receptors, the TCR and pre-TCR. These receptors employ families of protein tyrosine kinases to propagate their signals, Src Syk families. Genetic biochemical evidence has shown family are for normal T cell maturation. ZAP-70, a kinase, similarly been implicated as component in thymocyte development. Although genetic suggested is involved during development, definitive study expression not...
What is the transcriptome signature associated with poor performance of rescue IVM (rIVM) oocytes and how can we rejuvenate them?The GATA-1/CREB1/WNT signalling axis was repressed in rIVM oocytes, particularly those quality; restoration this may produce more usable oocytes.rIVM aims to mature (MII) for IVF through immature collected from stimulated ovaries. It not popular due limited success rate infertility treatment. Genetic aberrations, cellular stress absence cumulus cell support could...
To determine whether the multifocal visual evoked potential (mfVEP) technique can detect early functional damage in ocular hypertensive (OHT) and glaucoma suspect (GS) patients with normal standard achromatic automated perimetry (SAP) results.Twenty-five GS (25 eyes), 25 OHT 50 controls (50 eyes) were enrolled this study. All GS, control eyes had SAP as defined by a pattern deviation mean within 95% confidence interval hemifield test limits on Humphrey field 24-2 program. Eyes optic disc...
The tyrosine kinase Syk plays a critical role in the phagocytic pathway mediated by Fcgamma receptors (FcgammaR). In transfected COS1 cells co-expression of enhances FcgammaR phagocytosis. other member family, highly homologous Zap70, also signaling immunoglobulin gene family receptors, but does not increase efficiency FcgammaRs. tandem SH2 and domains Zap70 are separated nonhomologous region referred to as unique domain. Zap70's inability enhance phagocytosis was due domain 292, previously...
We describe the case of a 71-year-old-woman with 6-year history generalized eruptive keratoacanthomas on extremities. review diagnostic clinical and histologic features rare Grzybowski variant keratoacanthoma. The course this disease is chronic often demonstrates poor response to therapy.