José Sánchez-Sánchez

ORCID: 0000-0002-9782-4764
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About
Contact & Profiles
Research Areas
  • Allergic Rhinitis and Sensitization
  • Lichen and fungal ecology
  • Tendon Structure and Treatment
  • Sports injuries and prevention
  • Cancer Cells and Metastasis
  • Shoulder Injury and Treatment
  • Indoor Air Quality and Microbial Exposure
  • Myofascial pain diagnosis and treatment
  • Plant Pathogens and Fungal Diseases
  • Cancer, Hypoxia, and Metabolism
  • Chemical Reactions and Isotopes
  • Mediterranean and Iberian flora and fauna
  • Acupuncture Treatment Research Studies
  • Epigenetics and DNA Methylation
  • Musculoskeletal pain and rehabilitation
  • Mycorrhizal Fungi and Plant Interactions
  • Fern and Epiphyte Biology
  • Pain Mechanisms and Treatments
  • Urban Green Space and Health
  • Botany, Ecology, and Taxonomy Studies
  • Insect and Arachnid Ecology and Behavior
  • Laser Applications in Dentistry and Medicine
  • Angiogenesis and VEGF in Cancer
  • Nasal Surgery and Airway Studies
  • Orthopedic Surgery and Rehabilitation

Universidad de Salamanca
2014-2023

Servicio de Salud de Castilla La Mancha
2020-2023

Universidad Politécnica de Madrid
2023

University of Castilla-La Mancha
2013-2023

Complejo Hospitalario Universitario de Albacete
2013-2023

Hospital General de Almansa
2019-2023

Patellar tendinopathy has a high prevalence rate among athletes. Different therapeutic options can be found in the current literature, but none of them been clearly established as gold standard. The purpose this study is to compare, randomized controlled trial, clinical efficacy eccentric exercise combined with either an ultrasound-guided galvanic electrolysis technique (USGET) or conventional electrophysiotherapy treat patellar tendinopathy.Sixty patients diagnosed were into two groups....

10.1186/s40634-016-0070-4 article EN cc-by Journal of Experimental Orthopaedics 2016-11-16

Percutaneous electrolysis is an emerging intervention proposed for the management of tendinopathies. Tendon pathology characterized by a significant cell response to injury and gene expression. No study investigating changes in expression those genes associated with collagen regeneration remodeling extracellular matrix has been conducted. The aim this pilot was investigate after application percutaneous on experimentally induced Achilles tendinopathy collagenase injection animal model....

10.3390/jcm9103316 article EN Journal of Clinical Medicine 2020-10-15

Protein expression profiles are directly related to the different properties of cells and conditioned by cellular niche. As an example, they cause characteristic cell plasticity, epithelium-mesenchymal transition (EMT), drug resistance cancer cells. This article characterizes ten biomarkers these features in three human colorectal lines: SW-480, SW-620, DLD-1, evaluated flow cytometry; turn, oxaliplatin is studied through dose-response trials. The main present lines correspond EpCAM, CD-133,...

10.3390/biomedicines10051083 article EN cc-by Biomedicines 2022-05-06

Breast cancer is the leading cause of death among females in developed countries. Although implementation screening tests and development new therapies have increased probability remission, relapse rates remain high. Numerous studies indicated connection between cancer-initiating cells slow cellular cycle cells, identified by their capacity to retain long labeling (LT+). In this study, we perform assays showing how stem cell self-renewal modulating proteins, such as PEDF, can modify...

10.3390/cancers15225422 article EN Cancers 2023-11-15

Chenopodiaceae-Amaranthaceae pollen represents an allergenic risk for pollen-sensitive people. The aim of this study was to describe the dynamics in atmosphere Salamanca (mid-west Spain) during years 2000-2007. Measurements were performed by volumetric method using a Burkard spore trap located urban centre at height 20 m above ground level. This type mainly detected between late spring and summer, with Atmospheric Pollen Season (APS) registered May early October maximum concentrations...

10.3906/bot-1105-17 article EN TURKISH JOURNAL OF BOTANY 2012-01-01

Objective: To investigate the immediate effects of manipulation bilateral sacroiliac joints (SIJs) on plantar pressure distribution in asymptomatic participants standing position. Design: Randomized, controlled, double-blind clinical trial. Participants: Sixty-two men and women (mean age, 20.66±2.56 years) randomly assigned to 2 groups. Interventions: The experimental group underwent mobilization without tension hips supine position high-velocity, low-amplitude SIJs bilaterally. control only...

10.1089/acm.2013.0192 article EN The Journal of Alternative and Complementary Medicine 2014-02-04

The purpose of this double-blinded randomized controlled trial was to investigate whether percutaneous electrolysis (PE) is able activate endogenous pain modulation and its effects are dependent on the dosage galvanic current. A total 54 asymptomatic subjects aged 18–40 years were into three groups, receiving a single ultrasound-guided PE intervention that consisted needle insertion lateral epicondyle tendon: sham (without electrical current), low-intensity (0.3 mA, 90 s), high-intensity...

10.3390/jcm11102889 article EN Journal of Clinical Medicine 2022-05-20

Abstract Background : Breast cancer is the leading cause of death among females in developed countries. Although implementation screening tests and development new therapies has increased probability remission, relapse rates remain high. Numerous studies have indicated connection between initiating cells slow cellular cycle cells, identified by their capacity to retain long labelling (LT+). Methods In this study, we perform tumour cell culture dose-response assays adherent mamospheres...

10.21203/rs.3.rs-2636130/v1 preprint EN cc-by Research Square (Research Square) 2023-09-05

Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). PEDF (Pigmented Epithelium Derived Factor) is an anti-angiogenic, neurotrophic and self-renewal regulator molecule, also involved in CICs biology. Acute chronic exposition of colon cell lines to CT/CTE PEDF-derived peptides decreased drug-resistance conventional colorectal treatments, such as oxaliplatin or irinotecan. We confirmed a reduction irinotecan IC50 doses for all tested tumour lines. After xenograft...

10.18632/oncotarget.26085 article EN Oncotarget 2019-04-26

We report on two patients, successfully treated by the combination therapy of gemcitabine and 24-h intravenous infusion cisplatin, who were initially diagnosed with node-positive advanced urothelial cancer. Each patient had a very good clinical response underwent curative radical surgery after gemcitabine/cisplatin chemotherapy. A microscopically detailed examination surgically obtained specimens showed complete disappearance malignant cells in cases. As pilot study, we have used regimen...

10.6000/1927-7229.2013.02.04.2 article EN Journal of Analytical Oncology 2013-11-11

Percutaneous electrolysis consists of the application a galvanic electrical current throughout an acupuncture needle. It has been previously hypothesized that needling procedures’ neurophysiological effects may be related to endogenous pain modulation (EPM). This protocol study describes design double-blind (participant, assessor) randomized controlled trial with aim investigate whether percutaneous is able enhance EPM and effect different between two applications depending on dosage...

10.3390/brainsci11060801 article EN cc-by Brain Sciences 2021-06-17

Abstract Background Tendon dry needling is a potential treatment for tendinopathies. Several hypotheses have been proposed to explain its underlying mechanisms. No studies (to the best of our knowledge) investigated changes in gene expression. Objective To investigate histological and expression after application healthy Achilles tendons rats. Methods Six Sprague-Dawley male rats were randomly divided into two groups: no intervention or needling. Dry consisted three sessions (once per week)...

10.1093/pm/pnaa352 article EN Pain Medicine 2020-09-12
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