A5062067433- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Aquaculture Nutrition and Growth
- Hearing, Cochlea, Tinnitus, Genetics
- Biochemical Analysis and Sensing Techniques
- Retinal Development and Disorders
- Lipid Membrane Structure and Behavior
- Physiological and biochemical adaptations
- RNA and protein synthesis mechanisms
- Reproductive biology and impacts on aquatic species
- Tendon Structure and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Neurobiology and Insect Physiology Research
- Congenital heart defects research
- Animal Genetics and Reproduction
- Cellular transport and secretion
- Axon Guidance and Neuronal Signaling
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Myofascial pain diagnosis and treatment
- RNA Research and Splicing
- Connexins and lens biology
- Nerve injury and regeneration
- Developmental Biology and Gene Regulation
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2008-2024
Universidad de Salamanca
2008-2024
Instituto de Investigación Biomédica de Salamanca
2020-2024
Consejo Superior de Investigaciones Científicas
2003-2008
Centro de Investigación del Cáncer
2005-2008
Instituto de Neurociencias de Castilla y León
2006
Abstract The correct mobilization of cytoplasmic granules is essential for the proper functioning human neutrophils in host defense and inflammation. In this study, we have found that peripheral blood expressed high levels Rab27a, whereas Rab27b expression was much lower. This indicates Rab27a predominant Rab27 isoform present neutrophils. up-regulated during neutrophil differentiation HL-60 cells. Subcellular fractionation immunoelectron microscopy studies resting showed mainly located...
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven neuronal mechanisms that culminate in seizures, making them pivotal targets epilepsy research. Increasingly used advance this field, the genetically audiogenic seizure hamster from Salamanca (GASH/Sal) exhibits generalized seizures triggered by high-intensity acoustic stimulation and harbors significant genetic variants recently identified through whole-exome sequencing. Here, we addressed influence...
Percutaneous electrolysis is an emerging intervention proposed for the management of tendinopathies. Tendon pathology characterized by a significant cell response to injury and gene expression. No study investigating changes in expression those genes associated with collagen regeneration remodeling extracellular matrix has been conducted. The aim this pilot was investigate after application percutaneous on experimentally induced Achilles tendinopathy collagenase injection animal model....
A great number of studies have investigated changes induced by morphine exposure in gene expression using several experimental models. In this study, we examined during chronic to maturation and differentiation zebrafish CNS. Microarray analysis showed 254 genes whose was identified as different at least 1.3 fold change following compared controls. Of these, novel (grb2, copb2, otpb, magi1b, grik-l, bnip4 sox19b) been detected for the first time an animal model treated with morphine. We also...
The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, memory. zebrafish has been proposed candidate to study the vivo effects several drugs abuse discover new pharmacological targets. We report cloning, expression, characterization NOP from (drNOP). full-length cDNA codes protein 363 residues, which shows high sequence similarity other NOPs. Phylogenetic analysis indicates...
The GASH/Sal (Genetic Audiogenic Seizure Hamster, Salamanca) is a model of audiogenic seizures with the epileptogenic focus localized in inferior colliculus (IC). sound-induced exhibit short latency (7-9 s), which implies innate protein disturbances IC as basis for seizure susceptibility and generation. Here, we aim to study profile comparison controls. Protein samples from were processed enzymatic digestion then analyzed by mass spectrometry Data-Independent Acquisition mode. After...
The Pax2 transcription factor plays a crucial role in axon-guidance and astrocyte differentiation the optic nerve head (ONH) during vertebrate visual system development. However, little is known about its function regeneration. fish continuous growth can regenerate. Müller cells astrocytes of retina ONH play an important these processes. We demonstrate that pax2a goldfish highly conserved at least two transcripts are expressed nerve. Moreover, we show different populations goldfish: Pax2+...
The cortico-collicular pathway is a bilateral excitatory projection from the cortex to inferior colliculus (IC). It asymmetric and predominantly ipsilateral. Using microarrays RT-qPCR we analyzed changes in gene expression IC after unilateral lesions of auditory cortex, comparing ICs ipsi- contralateral lesioned side. At 15 days surgery there were mainly ipsilateral lesion. Regulation primarily involved inflammatory cascade genes, suggesting direct effect degeneration more than neuronal...
Abstract Background Tendon dry needling is a potential treatment for tendinopathies. Several hypotheses have been proposed to explain its underlying mechanisms. No studies (to the best of our knowledge) investigated changes in gene expression. Objective To investigate histological and expression after application healthy Achilles tendons rats. Methods Six Sprague-Dawley male rats were randomly divided into two groups: no intervention or needling. Dry consisted three sessions (once per week)...
Epilepsy is a neurological disorder characterized by abnormal neuronal excitability, with glutamate playing key role as the predominant excitatory neurotransmitter involved in seizures. Animal models of epilepsy are crucial advancing research faithfully replicating diverse symptoms this disorder. In particular, GASH/Sal (genetically audiogenic seizure-prone hamster from Salamanca) model exhibits seizures resembling human generalized tonic-clonic convulsions. A single nucleotide polymorphism...