A5091474442- Peripheral Artery Disease Management
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cerebrovascular and Carotid Artery Diseases
- Gallbladder and Bile Duct Disorders
- Cutaneous Melanoma Detection and Management
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Diabetic Foot Ulcer Assessment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Colorectal Cancer Screening and Detection
- Venous Thromboembolism Diagnosis and Management
- Nonmelanoma Skin Cancer Studies
- Pancreatitis Pathology and Treatment
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Coronary Interventions and Diagnostics
- Full-Duplex Wireless Communications
Saint John's Health Center
2022-2025
Providence College
2022-2023
Loyola University Medical Center
2015-2021
Loyola University Chicago
2016-2019
Cleveland Clinic
2006-2008
Purpose:To compare angiograms, considered the gold standard for diagnostic imaging of peripheral arterial disease (PAD), to corresponding histological sections popliteal and tibial vessels obtained after amputation determine if angiography fails define atheroma burden in “normal appearing” arteries patients with PAD. Methods:Between 2004 2006, 69 underwent a lower extremity severe tissue loss, gangrene, or pedal sepsis precluding limb salvage. Popliteal were harvested, perfusion-fixed,...
ABSTRACT Background There remains significant variability in the surgical management of thick melanoma patients with clinically node‐negative disease. We evaluated factors influencing overall survival (OS) these patients, focusing on primary tumor and nodal basin. Methods Using National Cancer Database, we identified 7647 diagnosed between 2012 2017 (> 4 mm, T4) 4332 had complete data met all inclusion criteria. These were stratified into three groups based assessment: sentinel lymph node...
Summary Activation of C‐X‐C motif chemokine receptor 4 (CXCR4) has been reported to result in lung protective effects various experimental models. The pharmacological CXCR4 modulation on the development acute respiratory distress syndrome (ARDS) after injury, however, are unknown. Thus, we studied whether blockade and activation influences ARDS a unilateral ischaemia–reperfusion injury rat model. Anaesthetized, mechanically ventilated animals underwent right ischaemia (series 1, 30 minutes;...
The baroreceptor at the carotid body plays an important role in hemodynamic autoregulation. Manipulation of during endarterectomy (CEA) or radial force from artery angioplasty and/or stenting (CAS) may cause both intraoperative and postoperative instability. purpose this study is to evaluate long-term effects CEA CAS on blood pressure (BP), heart rate (HR), subsequent changes antihypertensive medications.A retrospective chart review was performed identify patients who underwent between 2009...
Limited evidence-based management guidelines for resectable intrahepatic cholangiocarcinoma (ICC) currently exist. Using a large population-based cancer registry; the utilization rates and outcomes patients with clinical stages I-III ICC treated neoadjuvant chemotherapy (NAT) in relation to other treatment strategies were investigated, as predictors of regimen utilization. Oncologic compared between strategies. Amongst 2736 patients, was low; however, NAT use increased from 4.3% 7.2% (p =...
Chemokine (C-X-C motif) receptor 4 (CXCR4) agonists have been shown to protect lung endothelial barrier function in vitro. In vivo effects of CXCR4 modulation on permeability are unknown. Here we tested the agonist ubiquitin and antagonist AMD3100 vascular cytokine concentrations a rat hemorrhage model. Animals were hemorrhaged (mean arterial blood pressure 30 mmHg for min), treated with vehicle, (0.7 3.5 μmol/kg) or (3.5 μmol/kg), resuscitated crystalloids. Evans blue extravasation was...
Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether channel inhibitors can utilized stabilize hemodynamics reduce resuscitation fluid requirements after hemorrhagic shock.Anesthetized male Sprague-Dawley rats were instrumented with arterial venous catheters for pressure monitoring, hemorrhage resuscitation. Series 1: Linopirdine (Kv7 blocker, 0.1-6 mg/kg) or retigabine activator, 0.1-12...
Summary Recently, we demonstrated that Kv7 voltage‐activated potassium channel inhibitors reduce fluid resuscitation requirements in short‐term rat models of haemorrhagic shock. The aim the present study was to further delineate therapeutic potential and side effect profile blocker linopirdine various severe shock over clinically relevant time periods. Intravenous administration linopirdine, either before (1 or 3 mg/kg) after (3 a 40% blood volume haemorrhage, did not affect pressure...
Abstract Context Red blood cell distribution width (RDW) has been used to predict mortality during infection and inflammatory diseases. It also purported be predictive of following traumatic injury. Objective To identify the role RDW in predicting trauma patients. We sought development sepsis Methods A retrospective observational study was performed medical records for all adult patients admitted Loyola University Medical Center from 2007 2014. Patients fewer than four days were excluded....
The potential benefit of surgical resection intrahepatic cholangiocarcinoma in patients with locoregionally advanced disease has not been definitively determined.The National Cancer Database was queried to identify clinical evidence node-positive cholangiocarcinoma. Resected were stratified by margin status and lymph node ratio (nodes positive nodes harvested). Risk death determined using Cox regression models Kaplan-Meier survival functions.A total 1,425 T(any)N1M0 identified. Two hundred...
Correlations of atherosclerotic plaque attributes with clinical presentation have not been studied in peripheral arterial disease (PAD). The aim the current study was to identify variables associated alterations PAD morphology. Thirty-one patients underwent intravascular ultrasonography (IVUS) at time arteriography for symptomatic PAD. IVUS data were analyzed radiofrequency techniques quantification composition, volume, and total vessel volume. Associations between characteristics evaluated....
New onset atrial fibrillation (AF) is associated with poor outcomes in several different patient populations.To assess the effect of developing AF on cardiovascular events such as myocardial infarction (MI) and cerebrovascular accident (CVA) during acute index hospitalization for trauma patients.The Healthcare Cost Utilization Project State Inpatient Databases California Florida were used to identify adult patients (18 years age or older) who admitted between 2007 2010. After excluding a...