A5031036955- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- AI in cancer detection
- vaccines and immunoinformatics approaches
- Optical Coherence Tomography Applications
- Cytokine Signaling Pathways and Interactions
- Brain Metastases and Treatment
- Immune Response and Inflammation
- Cutaneous lymphoproliferative disorders research
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Advanced Biosensing Techniques and Applications
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Infectious Diseases and Mycology
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
Saint John's Health Center
2006-2025
Providence College
2022-2024
St. John's School
1999-2024
Cedars-Sinai Medical Center
2015-2019
University of California, Los Angeles
1989-2010
Cancer Institute (WIA)
1999-2007
Melanoma Institute Australia
2005
Millard Fillmore Suburban Hospital
2005
Molecular Oncology (United States)
1998-2001
St. John's University
2001
We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma.
Objective To evaluate the multicenter application of intraoperative lymphatic mapping, sentinel lymphadenectomy, and selective complete lymph node dissection (LM/SL/SCLND) for management early-stage melanoma. Summary Background Data The multidisciplinary technique LM/SL/SCLND has been widely adopted, but not validated in a trial. authors began international Multicenter Selective Lymphadenectomy Trial (MSLT) 5 years ago to survival patients with primary melanoma after wide excision alone...
The objective of this study was to evaluate, in an international multicenter phase III trial, the accuracy, use, and morbidity intraoperative lymphatic mapping sentinel node biopsy (LM/SNB) for staging regional nodal basin patients with early-stage melanoma.Since our introduction LM/SNB 1990, technique has been widely adopted become part American Joint Committee on Cancer (AJCC) system. Eleven years ago, authors began Multicenter Selective Lymphadenectomy Trial (MSLT-I) compare 2 treatment...
The effects of IL-4 on IL-1 and TNF gene expression in human peripheral monocytes (PBM) were examined. Highly purified PBM cultured for 24 to 96 h the presence produce neither nor protein. RNA hybridization studies demonstrated that does not induce transcription or TNF. Preincubation with did, however, inhibit LPS-induced production a dose- time-related fashion. Maximal inhibition occurred after incubation 200 U/ml IL-4. suppressed alpha, beta, mRNA. These results suggest modulates monocyte...
PURPOSE We developed intraoperative lymphatic mapping with selective lymphadenectomy (SLND) to identify micrometastatic spread of cutaneous melanoma regional lymph nodes. This study was undertaken assess the sensitivity and specificity our technique in patients clinical stage I (CS-I) head or neck. PATIENTS AND METHODS Seventy-two CS-I underwent primary melanomas located on head, neck, upper chest/back draining Key (sentinel) cervical nodes drainage basin were identified, selectively excised...
PURPOSE: Detection of micrometastases in the regional tumor-draining lymph nodes is critical for accurate staging and prognosis melanoma patients. We hypothesized that a multiple-mRNA marker (MM) reverse transcriptase–polymerase chain reaction (RT-PCR) assay would improve detection occult metastases sentinel node (SN), compared with hematoxylin eosin (H&E) staining immunohistochemistry (IHC), MM expression predictive disease relapse. PATIENTS AND METHODS: Seventy-two consecutive patients...
In Brief Objective: Lymphatic mapping and sentinel lymphadenectomy (LM/SL) have been applied to virtually all solid neoplasms since our original description of LM/SL for melanoma. Our objectives were determine the diagnostic therapeutic utility LM/SL, investigate carbon dye microanatomy lymphatic flow within node (SN), prognostic accuracy molecular assessment SN. Methods: Since 1985, 1599 patients with AJCC Stage I/II melanoma treated by at institution 4590 wide excision (WE) without nodal...
Hypothesis:The clinical treatment of patients with stage IV melanoma according to criteria the American Joint Committee on Cancer (AJCC) is controversial because 5-year survival rate approximately 5%.Specific clinicopathologic factors are predictive following curative surgery.Design: Cohort analysis 1574 successive undergoing surgical resection metastatic for a 29-year period.Patients received follow-up routine basis serial examinations and radiographic studies.The median time was 19 months...
The curative effect of surgery in certain patients with metastatic melanoma suggests the presence endogenous antitumor responses. Because is immunogenic, we investigated whether a therapeutic cancer vaccine called Canvaxin (CancerVax Corporation, Carlsbad, CA) could enhance immune responses and thereby prolong survival.Of 263 who underwent complete resection American Joint Committee on Cancer stage IV melanoma, 150 received postoperative adjuvant therapy 113 did not. overall survival (OS)...
Approximately 20% of sentinel node (SN) positive melanoma patients have additional non-SN (NSN) metastasis. The rationale for this study was to identify the factors associated with nodal disease, as a method determine which may most benefit from completion lymph dissection (CLND).During 1990 2002, 1,599 undergone SN biopsy at our institute. 19.5% underwent CLND tumor-positive SN. One hundred ninety-one these had clinicopathologic information available review. Univariate analyses used chi2...
Objective To determine whether adjuvant postoperative active specific immunotherapy with a therapeutic polyvalent vaccine (PV) called Canvaxin can prolong survival following complete resection of melanoma metastatic to regional nodes (American Joint Committee on Cancer [AJCC] stage III melanoma). Summary Background Data Despite lymphadenectomy, 5-year overall (OS) for patients lymph is only 20% 50%, depending the number tumor-involved nodes. In 1984, authors began phase II trials PV as...
Purpose: Regional lymph node status is the strongest prognostic determinant in early-stage melanoma. Lymphatic mapping and sentinel lymphadenectomy (LM/SL) standard to stage regional nodes because it accurate minimally morbid, yet its role for thin (≤ 1.5 mm) primary melanomas unknown. Patients Methods: Our melanoma database of more than 10,000 patients was reviewed with ≤ 1.50 mm thick who underwent LM/SL. All had lymphoscintigrams LM/SL via dye alone or radiopharmaceutical. tumor-positive...
Malignant melanoma can metastasize to almost any organ site. Optimal management requires sensitive radiographic evaluation of the entire body. The optimal patients with metastatic accurate assessment extent disease (EOD). objective this study was evaluate accuracy fluorine-18 deoxyglucose (FDG) whole-body positron emission tomography (PET) in determination EOD and its impact on surgical medical decisions. Forty-nine (30 men, 19 women; aged 25–83 years) known or suspected underwent using...
Melanoma sentinel nodes (SN) show evidence of immunosuppression prior to tumor metastasis. Interleukin (IL)-10 and IFN-gamma can induce dendritic cells (DC) that express immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO). The goals this study are evaluate the role melanoma in SN assess reversibility by a cytokine therapy.Fifty-seven clinical stage I/II patients underwent wide local excision lymphadenectomy (WLE/SL), with removal non-SN. In 21 patients, nodal RNA was analyzed...
The 615-bp 5' flanking region of the human TNF-alpha/cachectin gene was isolated and ligated to luciferase reporter gene. In addition, a series truncated promoter constructs generated by exonuclease III digestion. activity these studied in transient transfection system using TNF-alpha-producing U937 cell line. Full-length TNF constructions extending from -615 -95 bp relative transcription start site (TSS) could be induced phorbol esters. A construct within 36 TSS (and 11 TATAA box) inactive....
ABSTRACT Background There remains significant variability in the surgical management of thick melanoma patients with clinically node‐negative disease. We evaluated factors influencing overall survival (OS) these patients, focusing on primary tumor and nodal basin. Methods Using National Cancer Database, we identified 7647 diagnosed between 2012 2017 (> 4 mm, T4) 4332 had complete data met all inclusion criteria. These were stratified into three groups based assessment: sentinel lymph node...