A5045570910- Neuroblastoma Research and Treatments
- Retinoids in leukemia and cellular processes
- Circadian rhythm and melatonin
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Genetics, Aging, and Longevity in Model Organisms
- Thermoregulation and physiological responses
- Cancer therapeutics and mechanisms
- Signaling Pathways in Disease
- DNA Repair Mechanisms
- Sirtuins and Resveratrol in Medicine
- PARP inhibition in cancer therapy
- Glioma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Redox biology and oxidative stress
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Dietary Effects on Health
The University of Texas at San Antonio
2023-2025
The University of Texas Health Science Center at San Antonio
2023-2025
Longevity Biotech (United States)
2024-2025
The University of Texas Health Science Center at Houston
2024-2025
Mays Cancer Center at UT Health San Antonio
2024
Texas Tech University
2019-2021
Texas Tech University Health Sciences Center
2019-2021
A ketogenic diet (KD) is a high-fat, low-carbohydrate that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different and, at ages, induce cellular senescence in multiple organs, including heart kidney. This effect mediated through adenosine monophosphate–activated protein kinase (AMPK) inactivation mouse double minute 2 (MDM2) by caspase-2, leading p53...
ATM activation at telomeres confers chemoresistance in ALT neuroblastoma and is reversible preclinical models by knockdown or inhibition.
Circadian disruption is pervasive in modern society and associated with increased risk of disease. Chronic jet lag paradigms are popular experimental tools aiming to emulate human circadian experienced during rotating night shift work. induces metabolic phenotypes tied liver systemic functions, yet lack a clear definition for how rhythmic physiology impaired under these conditions hinders the ability identify underlying molecular mechanisms. Here, we compared 2 common chronic found that...
Molecular clocks and daily feeding cycles support metabolism in peripheral tissues. Although the roles of local are well defined at transcriptional level, their impact on governing protein abundance tissues is unclear. Here, we determine relative contributions molecular liver muscle proteomes during active phase mice. LC-MS/MS was performed gastrocnemius harvested 4 h into dark from WT, Bmal1 KO, dual liver- muscle-Bmal1-rescued mice under either ad libitum or time-restricted phase....
Abstract Recurrent high-risk neuroblastoma is a childhood cancer that often fails to respond therapy. Fenretinide (4-HPR) cytotoxic retinoid with clinical activity in recurrent and venetoclax (ABT-199) selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). We evaluated 4-HPR + ABT-199 preclinical models neuroblastoma. Patient-derived cell lines xenografts from progressive were tested. Cytotoxicity was by DIMSCAN, apoptosis flow cytometry, gene expression RNA sequencing,...
DNA-damaging chemotherapy is a major component of therapy for high-risk neuroblastoma, and patients often relapse with treatment-refractory disease. We hypothesized that DNA repair genes increased expression in alkylating agent resistant models would provide therapeutic targets enhancing chemotherapy. In-vitro cytotoxicity agents 12 patient-derived neuroblastoma cell lines was assayed using DIMSCAN, mRNA 57 repair, three transporter, two glutathione synthesis assessed by TaqMan low-density...
ABSTRACT Objective Molecular clocks and daily feeding cycles support metabolism in peripheral tissues. Although the roles of local is well defined at transcriptional level, their impact on governing protein abundances tissues unclear. Here, we determine relative contributions molecular clock liver muscle proteomes during feeding. Methods LC-MS/MS was performed skeletal harvested four hours into dark phase from wild-type (WT), Bmal1 knockout (KO), liver- muscle- -rescued (LMRE) mice housed...
Abstract Cancers overcome replicative immortality by activating either telomerase or an alternative lengthening of telomeres (ALT) mechanism. ALT occurs in ∼ 25% high-risk neuroblastomas and relapse progression neuroblastoma patients during after front-line therapy is frequent almost uniformly fatal. Temozolomide + irinotecan commonly used as salvage for neuroblastoma. Patient-derived cell-lines xenografts established from relapsed demonstrated de novo resistance to temozolomide (as SN-38...
<p>Supplementary Data and Tables</p>
<p>Supplementary Data and Tables</p>
<div>Abstract<p>Recurrent high-risk neuroblastoma is a childhood cancer that often fails to respond therapy. Fenretinide (4-HPR) cytotoxic retinoid with clinical activity in recurrent and venetoclax (ABT-199) selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). We evaluated 4-HPR + ABT-199 preclinical models neuroblastoma. Patient-derived cell lines xenografts from progressive were tested. Cytotoxicity was by DIMSCAN, apoptosis flow cytometry, gene...
<div>Abstract<p>Recurrent high-risk neuroblastoma is a childhood cancer that often fails to respond therapy. Fenretinide (4-HPR) cytotoxic retinoid with clinical activity in recurrent and venetoclax (ABT-199) selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). We evaluated 4-HPR + ABT-199 preclinical models neuroblastoma. Patient-derived cell lines xenografts from progressive were tested. Cytotoxicity was by DIMSCAN, apoptosis flow cytometry, gene...