Abstract Mice and rats are widely used to explore mechanisms of mammalian social behavior in health disease, raising the question whether they actually differ their behavior. Here we address this by directly comparing investigation between two mouse rat strains most frequently for behavioral studies as models neuropathological conditions: C57BL/6 J mice Sprague Dawley (SD) rats. Employing novel experimental systems analysis both subjects stimuli during preference test, reveal marked...

Many mammals rely on pheromones for mediating social interactions. Recent studies indicate that both the main olfactory system (MOS) and accessory (AOS) detect process pheromonal stimuli, yet functional difference between these two chemosensory systems remains unclear. We hypothesized distinction MOS AOS is type of sensory information processing performed by each system. Here we compared electrophysiological responses mitral cells recorded from bulb (AOB) (MOB) in acute mouse brain slices to...

Persistent activity has been reported in many brain areas and is hypothesized to mediate working memory emotional states rely upon network or biophysical feedback. Here, we demonstrate a novel mechanism by which persistent neuronal can be generated without feedback, relying instead on the slow removal of Na+ from neurons following bursts activity. We show that mitral cells accessory olfactory bulb (AOB), plays major role mammalian social behavior, may respond brief sensory stimulation with...

Changes in intracellular Na+ concentration ([Na+]i) are rarely taken into account when neuronal activity is examined. As opposed to Ca2+, [Na+]i dynamics strongly affected by longitudinal diffusion, and therefore they governed the morphological structure of neurons, addition localization influx efflux mechanisms. Here, we examined their effects on computation three multi-compartmental models, representing distinct cell types: accessory olfactory bulb (AOB) mitral cells, cortical layer V...

Several species of glaphyrid (Scarabaeoidea: Glaphyridae) beetles forage and mate on Mediterranean red bowl-shaped flowers. In anemones poppies in Israel, female occupy only a subset the flowers, do not aggregate, are hidden below petals. This raises question how males find their mates. present study, we investigated hypothesis that females orient to similar plant-generated cues, thereby increasing encounter prospects. Previous studies have demonstrated beetle attraction models increases...

Rhythmic neuronal activity of multiple frequency bands has been described in many brain areas and attributed to numerous functions. Among these, little is known about the mechanism role infra-slow oscillations, which have demonstrated recently mouse accessory olfactory bulb (AOB). Along with prolonged responses stimuli distinct network connectivity, they inexplicably affect AOB processing social relevant stimuli. Here, we show that assemblies mitral cells are synchronized by lateral...

Response variability is an essential and universal feature of sensory processing behavior. It arises from fluctuations in the internal state brain, which modulate how information represented transformed to guide behavioral actions. In part, brain shaped by recent network activity, fed back through recurrent connections neuronal excitability. However, degree these interactions influence response spatial temporal scales across they operate, are poorly understood. Here, we combined population...

Abstract The giant fiber system (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly Drosophila melanogaster , usually face of threatening visual stimulus. Two branches circuit promote by stimulating an jump followed flight initiation. A recent work demonstrated age-associated decline speed signal propagation through circuit, measured as stimulus-to-muscle depolarization latency. likely due to diminishing number inter-neuronal gap junctions GFS...

Social interactions between mammalian conspecifics rely heavily on molecular communication via the main and accessory olfactory systems. These two chemosensory systems show high similarity in organization of information flow along their early stages: social chemical cues are detected by sensory neurons epithelium vomeronasal organ. then convey to (MOB) (AOB) bulbs, respectively, where they synapse upon mitral cells that project higher brain areas. Yet, functional difference these remains...

Abstract Significance Light-sheet microscopy is a powerful imaging technique that achieves optical sectioning via selective illumination of individual sample planes. However, when the contains opaque or scattering tissue, incident light-sheet may not be able to uniformly excite entire sample. For example, in context larval zebrafish whole-brain imaging, occlusion by eyes prevents access significant portion brain during common implementations using unidirectional illumination. Aim We...

SignificanceLight-sheet microscopy is a powerful imaging technique that achieves optical sectioning via selective illumination of individual sample planes. However, when the contains opaque or scattering tissues, incident light sheet may not be able to uniformly excite entire sample. For example, in context larval zebrafish whole-brain imaging, occlusion by eyes prevents access significant portion brain during common implementations using unidirectional illumination.AimWe introduce...

ABSTRACT The Giant Fiber System (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly Drosophila melanogaster , usually face of threatening visual stimulus. Two branches circuit promote by stimulating an jump followed flight initiation. Our recent work demonstrated age-associated decline speed signal propagation through circuit, measured as stimulus-to-muscle depolarization latency. likely due to diminishing number interneuronal gap junctions GFS...

Abstract The ongoing activity of neuronal populations represents an internal brain state that influences how sensory information is processed to control behaviour. Conversely, external inputs perturb network dynamics, resulting in lasting effects persist beyond the duration stimulus. However, relationship between these dynamics and circuit architecture their impact on processing, cognition behaviour are poorly understood. By combining cellular-resolution calcium imaging with mechanistic...