A5075709846- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- RNA modifications and cancer
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- GDF15 and Related Biomarkers
- Animal Disease Management and Epidemiology
- Telomeres, Telomerase, and Senescence
- Viral Infections and Immunology Research
- Vector-Borne Animal Diseases
- Virus-based gene therapy research
- interferon and immune responses
- Mosquito-borne diseases and control
- RNA and protein synthesis mechanisms
Komipharm International (South Korea)
2025
Seoul National University
2019-2023
Seoul National University of Science and Technology
2020
Kyungpook National University
2019
Many studies have been conducted to improve economically important livestock traits such as feed efficiency and muscle growth. Genome editing technologies represent a major advancement for both basic research agronomic biotechnology development. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technical platform is powerful tool used engineer specific targeted loci. However, the potential occurrence of off-target effects, including cleavage unintended targets,...
African swine fever virus (ASFV) has substantially spread worldwide, resulting in significant economic losses the industry. Despite extensive research, no ASF vaccine surpassed effectiveness of live attenuated vaccines. For instance, ASFV-G-ΔI177L/ΔLVR demonstrated good efficacy and safety, along with prolonged persistence antibodies after vaccination. Therefore, we aimed to evaluate its potential for protection against highly virulent homologous viruses based on changes farm environment. To...
Abstract Background In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, more efficient animal production. Chicken myoblast cells, which are required muscle development regeneration, particularly important because chicken growth closely related mass. Results this study, we induced expression of microRNA-146b-5p mediated by piggyBac transposon system in primary (pCM)...
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, which is the most efficient and reliable tool for precisely targeted modification of genome living cells, has generated considerable excitement industrial applications as well scientific research. In this study, we developed a gene-editing detection system chick embryo sexing during embryonic stage.By combining CRISPR/Cas9 technical platform germ cell-mediated germline...
Innate immunity, as an organism's first line of defense, plays a crucial role in rapidly responding to and protecting the body against invading pathogens. As cytosolic RNA sensor for viral infections, including infections caused by influenza virus, innate immune system chickens has 2 major pathogen-recognition receptors (PRRs): Toll-like receptor 3 (TLR3) melanoma differentiation-associated protein 5 (MDA5). The signaling pathways activated PRRs are complex, systemic processes that underlie...
A bioreactor can be used for mass production of therapeutic proteins and other bioactive substances. Although various methods have been developed using microorganisms animal cells, advanced strategies are needed the efficient biofunctional proteins. In microorganisms, post-translational glycosylation modification not performed properly, while cell systems require more time expense. To overcome these problems, new products from transgenic animals considered, such as genetically modified cow’s...
Abstract In poultry industry as well livestock, the precise genetic information is being required for improving economic traits. Thus, functional genomic studies are widely conducted to build and faster, healthier more-efficient animal production. Especially, chicken myoblast cells which muscle development regeneration important because growth performance closely related mass. this study, we induced expression of microRNA-146b (miR-146b) mediated by piggyBac transposon system in (pCM cells)....
Abstract Background: In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, more efficient animal production. Chicken myoblast cells, which are required muscle development regeneration, particularly important because chicken growth closely related mass. Results: this study, we induced expression of microRNA-146b-5p mediated by piggyBac transposon system in primary...
Abstract Background: In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, more efficient animal production. Chicken myoblast cells, which are required muscle development regeneration, particularly important because chicken growth closely related mass. Results: this study, we induced expression of microRNA-146b-5p mediated by piggyBac transposon system in primary...