A5027686472- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cardiac Structural Anomalies and Repair
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Cerebrovascular and Carotid Artery Diseases
- Mechanical Circulatory Support Devices
- Congenital Diaphragmatic Hernia Studies
- Aortic Thrombus and Embolism
- Cardiac pacing and defibrillation studies
- Trauma Management and Diagnosis
- Cardiac Arrest and Resuscitation
- Connective tissue disorders research
- Cardiac Ischemia and Reperfusion
- Meningioma and schwannoma management
- Cardiac, Anesthesia and Surgical Outcomes
- Pericarditis and Cardiac Tamponade
- Diabetic Foot Ulcer Assessment and Management
University of Tsukuba
1999-2024
University of Tsukuba Hospital
2016-2022
Medical Center Hospital
2009
Tsukuba Medical Center Hospital
1998-2006
Abnormal mechanosensing of smooth muscle cells (SMCs) resulting from the defective elastin-contractile units has been suggested to drive formation thoracic aortic aneurysms; however, precise molecular mechanism not elucidated.
Abstract Aging induces numerous cellular disorders, such as the elevation of reactive oxygen species (ROS), in a number type cells, including mesenchymal stem cells (MSCs). However, correlation ROS and impaired healing abilities well whether or not inhibition elevating results rejuvenation elderly MSCs is unclear. The aged has thus recently received attention field regenerative medicine. Specifically, extracellular vesicles (EVs) act novel tool for cell due to their gene transfer ability...
Type 2 diabetes mellitus (T2DM) is associated with endothelial dysfunction, which results in delayed wound healing. Mesenchymal stem cells (MSC) play a vital role supporting (EC) and promoting healing via paracrine effects through their secretome-containing extracellular vesicles. We previously reported the impaired ability of adipose tissue-derived MSC from T2DM donors; however, whether vesicles isolated (dEV) exhibit altered functions comparison to those derived healthy donors (nEV) still...
Triple negative breast cancer (TNBC) is associated with worse outcomes and results in high mortality; therefore, great efforts are required to find effective treatment. In the present study, we suggested a novel strategy treat TNBC using mesenchymal stem cell (MSC)-derived extracellular vesicles (EV) transform behaviors cellular communication of cells (BCC) other non-cancer related tumorigenesis metastasis. Our data showed that, BCC after being internalized EV derived from Wharton's Jelly...
Objective: Remodeling of the extracellular matrix plays a vital role in cardiovascular diseases. Using mouse model postnatal ascending aortic aneurysms (termed Fbln4 SMKO ), we have reported that abnormal mechanosensing led to aneurysm formation with an upregulation mechanosensitive transcription factor, Egr1 (Early growth response 1). However, and its upstream regulator(s) initiation development their relationship aneurysmal microenvironment are unknown. Approach Results: To investigate...
We present an experience with axillary artery and transapical aortic cannulation for cardiopulmonary bypass according to our indication. could simply achieve antegrade flow using the two methods satisfactory result.
Two-dimensional perfusion angiography (2DPA) is utilized in hybrid operating rooms. 2DPA produces color map images and functional parameters to provide more robust visual quantitative evaluations than conventional angiography. Its efficacy was suggested five patients following bypass surgery; unexpected results were obtained one patient, leading a decision perform surgical re-anastomosis. Furthermore, we found that the general anesthesia eliminates body movements tend disrupt results. useful...
Triple-negative breast cancer (TNBC) is a highly aggressive and invasive type of cancer. In addition, 2 diabetes mellitus (T2DM) recognized as risk factor for metastasis, which associated with mortality in patients Cancer-associated fibroblasts (CAFs) generated from adipose tissue-derived mesenchymal stem cells (AT-MSCs) play vital role the progression TNBC. However, to date, whether T2DM affects ability AT-MSCs differentiate into CAFs still unclear. this study, we found that coculture TNBC...
Four cases of lower extremity hematoma in patients undergoing anticoagulant therapy after heart valve replacement are herein reported, with special emphasis on the comparative diagnostic value ultrasonography and computerized tomography. Although conservative management is sufficient for no neurological impairment, needle aspiration autolysis hematoma, which can be confirmed by CT study, also recommended.
Introduction SARS-CoV-2 infection increases the risk of worse outcomes in cancer patients, including those with breast cancer. Our previous study reported that membrane protein (M-protein) promotes malignant transformation triple-negative cells (triple-negative BCC). Methods In present study, effects M-protein on ability extracellular vesicles (EV) derived from BCC to regulate functions tissue stem facilitating tumor microenvironment were examined. Results results showed EV M-protein-induced...
Glucocorticoids are common anti-inflammatory factors; however, they have been reported to side effects that delay the wound healing process. In a previous study, we found mesenchymal stem cells isolated from adipose tissue of patients with long-term glucocorticoid treatment (sAT-MSC) showed impaired ability due downregulation SDF-1. this aimed clarify mechanisms by which SDF-1 is regulated in sAT-MSC focusing on roles hypoxia-inducible factors (HIFs). Our data suggested impairment HIF-1α and...
Introduction: The therapeutic effects of endothelial progenitor cells (EPC) in neovascularization have been suggested; however, to date, few studies conducted on the ability EPC-derived extracellular vesicles (EV) rescue ischemic tissues. In order examine functional sources EV for cell-free therapy diseases, we compared functions EPC-EV and those Wharton's Jelly-derived mesenchymal stem cell (WJ-EV) flap mouse model. Results conclusion: Our results demonstrated that intravenous injection,...