A5063630602- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Bipolar Disorder and Treatment
- Psychedelics and Drug Studies
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Dental Erosion and Treatment
- Endodontics and Root Canal Treatments
- Orthodontics and Dentofacial Orthopedics
- Parasite Biology and Host Interactions
- Forensic Entomology and Diptera Studies
- Dental Health and Care Utilization
- Autism Spectrum Disorder Research
- Genomic variations and chromosomal abnormalities
- Traumatic Brain Injury Research
- Paleopathology and ancient diseases
- Psychosomatic Disorders and Their Treatments
- Cancer Research and Treatment
- Computational Drug Discovery Methods
Queen's University
2024-2025
National Council for Scientific and Technological Development
2024
Kingston Health Sciences Centre
2024
Universidade de São Paulo
2009-2024
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2010-2015
Universidade de Ribeirão Preto
2012-2015
University of El Salvador
2013
Translational Health Science and Technology Institute
2012
Clinics Hospital of Ribeirão Preto
2010
Instituto de Neurociências e Comportamento
2009
OBJECTIVE: The last decade has seen increasing evidence of dysfunctions in the endogenous cannabinoid system schizophrenia and its relationship with typical cognitive impairment disorder. Studies animal models, healthy volunteers, psychotic patients clearly suggest an antipsychotic-like effect cannabidiol. This study investigated effects cannabidiol on selective attention 28 schizophrenic using Stroop Color Word Test these patients' electrodermal responsiveness to auditive stimuli. METHOD:...
Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders
Major Depressive Disorder (MDD) is a prevalent mood disorder characterized by persistent low and anhedonia, significantly impacting cognitive function daily living. Despite available pharmacological treatments, nearly one-third of individuals with MDD do not achieve adequate symptom relief conventional treatments. The ketogenic diet (KD), high-fat, low-carbohydrate that induces ketosis, has emerged as potential non-pharmacological intervention for MDD. To provide comprehensive perspective on...
Better treatments for schizophrenia are urgently needed. The therapeutic use of the nitric oxide (NO)-donor sodium nitroprusside (SNP) in patients with has shown promising results. role NO is still unclear, and modulation unexplored ketamine (KET) animal models to date. In present study, we compared behavioral effects pre- post-treatment SNP, glyceryl trinitrate (GTN), methylene blue (MB) acute KET model schizophrenia. study was designed test whether GTN, MB treatment taken after...
Objective: Olanzapine is an atypical antipsychotic drug used to treat schizophrenia. Some of the adverse effects related its use are obesity, hyperlipidemia, type 2 diabetes and hypertension, which may result in development metabolic syndrome. This study aimed investigate a possible increase some anthropometric biochemical parameters, existence any correlation between them Brazilian patients with schizophrenia treated olanzapine mid term. Methods: Thirty subjects were evaluated, 16 women 14...
Background: Neuropsychiatric sequelae are the predominant long-term disability after traumatic brain injury (TBI). This study reports a case of late-onset social anxiety disorder (SAD) following TBI.Case report: A patient that was spontaneous and extroverted up to 18-years-old started exhibit significant symptoms. These symptoms became progressively worse he sought treatment at age 21. He had previous history (TBI) 17. Neuroimaging investigations (CT, SPECT MRI) showed bony protuberance on...
One of the subjects that most concerns physicians is treatment-resistance. About 30%–60% schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory patients. Clozapine has been drug choice in such cases. However, approximately 30% them clozapine either. Here, we describe a patient with an initial diagnosis who had history dramatic aggressiveness. this case, “refractoriness” was wrong diagnosis. A case psychosis secondary epilepsy treated for...
Despite the wide variety of currently available antipsychotics, their efficacy is limited only to improvement in positive symptoms. In addition, longitudinal cohort studies patients with first episode psychosis show worsening different psychopathological domains and progressive loss brain gray matter volumes. Beyond changes neurotransmitter systems, most notably dopaminergic glutamatergic there growing evidence an immune inflammatory component pathophysiology schizophrenia, indicating...
"Iracema comes with the pot full of green liquor. The shaman decrees dreams to each warrior and distributes wine jurema, which carries brave Tabajara heaven." José de Alencar, in his poetic novel "Iracema" (1865)1. IntroductionThe "wine jurema", used ancient Brazilian shamanic rituals, is rich N,N-dimethyltryptamine (DMT), a naturally occurring tryptamine like serotonin melatonin. Widely found plants animals, DMT main component some botanical tisanes for centuries as channel communication...
To assess the sealing properties of three different luting materials used for cementation full cast crowns on extracted human premolars.Thirty noncarious premolars were prepared in a standardized fashion crown restorations. All margins placed dentin. After impressions preparations, stone dies fabricated which copings waxed, type III alloy using laboratory methods. Teeth randomly assigned to groups 10 samples each (n=10), following cements used: 1) resin-modified glass ionomer cement, Rely X...
La prevalencia de sexo y el padron edad relacionado a los diferentes tipos rehabilitaciones protesicas son variables importantes que deben ser estudiadas. De esta manera, objetivo este estudio fue evaluar perfil genero en pacientes rehabilitados con protesis dentales un curso Odontologia durante periodo cinco anos. Fueron evaluados 638 fichas recibieron parcial fija (PPF), removible (PPR) total (PT). Las PPR fueron clasificadas dentomucosoportada (DM) o dentosoportadas (D). Para analisis...