A5053145357- RNA modifications and cancer
- Palliative Care and End-of-Life Issues
- RNA Research and Splicing
- Global Health Workforce Issues
- Ubiquitin and proteasome pathways
- Patient Dignity and Privacy
- Diversity and Career in Medicine
- RNA and protein synthesis mechanisms
- Patient-Provider Communication in Healthcare
Memorial Sloan Kettering Cancer Center
2023-2024
Meharry Medical College
2022-2023
RELX Group (United States)
2023
Kettering University
2023
University of Pittsburgh
2022
Highlights•GPATCH8 is required for mutant SF3B1-dependent splicing alterations•GPATCH8 involved in quality control of intronic branchpoint selection•GPATCH8 opposes activity SUGP1, and each competes interaction with DHX15•Deletion GPATCH8 corrects aberrant differentiation SF3B1-mutant MDS cellsSummaryMutations the RNA factor gene SF3B1 are common across hematologic solid cancers result widespread alterations splicing, yet there currently no therapeutic means to correct this mis-splicing....