A5101644901- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Adipose Tissue and Metabolism
Jeonbuk National University
2020-2021
Recent work provides evidence for the new terminology, 'endoplasmic reticulum (ER) stress response or sensing failure', in relation to metabolic disease. We seek identify and amass possible conditions of ER failure various age-related pathogenesis, including obesity diabetes. is an important organelle found eukaryotic cells that serves functions, protein synthesis, folding, transporting synthesized proteins. Its physiological perturbations affect its function, increase protein-folding...
Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds multiple tumor cells. However, not much attention has paid to elucidate its mechanism of action. Here, chalcone was demonstrated trigger endoplasmic reticulum (ER) stress-induced apoptosis through sulfonation IRE1α by ER-localized NADPH oxidase 4 (NOX4). IRE1α-sulfonation at cysteine residue shown induce "regulated IRE1α-dependent decay" (RIDD) mRNA...
Age-associated persistent ER stress is the result of declining chaperone systems that reduces cellular functions, induces apoptosis, and leads to age-related diseases. This study investigated previously unknown regulatory mechanism TMBIM6 during age-associated hepatic abnormalities. Wild-type (WT) knockout (TMBIM6−/−) mice liver, human liver samples from different age groups were used demonstrate effect physiological aging on liver. For rescue experiments, TMBIM6−/− old stable cell lines...