A5088612880- CAR-T cell therapy research
- Virus-based gene therapy research
- Nanowire Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Algal biology and biofuel production
- Vaccine Coverage and Hesitancy
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Sesame and Sesamin Research
- Nanoplatforms for cancer theranostics
- COVID-19 diagnosis using AI
- Medicinal Plants and Bioactive Compounds
- Adenosine and Purinergic Signaling
- Hydrogels: synthesis, properties, applications
Tarbiat Modares University
2019-2025
Background Application of antibodies in therapeutics and diagnostics are growing Continually. Herein, we aimed to find the most qualified immunoglobulin (Ig) chemical preparation method.
Background/Objectives: The SARS-CoV-2's high mutations and replication rates contribute to its infectivity resistance current vaccinations treatments. primary cause of most treatments aligns within the coding regions for spike S protein SARS-CoV-2 that has mutated. As a potential novel immunotherapy, we generated fusion composed soluble ACE2 (sACE2) linked llama-derived anti-CD16 targets different variants proteins enhances natural killer cells target infected cells. Methods: Here,...
In the past few years, research has focused on design and development of natural polymers-based hydrogels owing to their inherent features as well numerous application ranges. this context, polysaccharide-based have attracted significant interest mainly due superior physicochemical biological characteristics. However, these types biomaterials 'suffer' from some problems. This review aims give an update diverse optimization strategies used improve properties based polysaccharides for...
Background Chimeric antigen receptor (CAR)-T cell therapy has established itself as a potent therapeutic option for certain patients with relapsed/refractory (R/R) hematologic malignancies. To date, four CD19-redirected CAR-T products have been granted the United States Food and Drug Administration (FDA) approval medical use. However, all of these are equipped single-chain fragment variable (scFv) their targeting domains. Camelid single-domain antibodies (VHH or nanobody) can also be used...
Abstract Background The immunogenicity of the antigen-recognition domains chimeric antigen receptor (CAR)-T cells leads to immune responses that may compromise antitumor effects adoptively transferred T cells. Herein, we attempt humanize a CD19-specific VHH (named H85) using in silico techniques and investigate impact domain humanization on CAR expression density, cytokine secretion, cytolytic reactivity CAR-T based humanized VHH. Methods H85 was HuH85), then HuH85 compared with terms...
As the most lethal gynecologic oncological indication, carcinoma of ovary has been ranked as 5 th cause cancer-related mortality in women, with a high percentage patients being diagnosed at late stages disease and five-year survival ~ 30%. Ovarian cancer conventionally undergo surgery for tumor removal followed by platinum- or taxane-based chemotherapy; however, experience relapse. Cancer immunotherapy regarded silver lining treatment various immunological indications; mirvetuximab...
Abstract Background Monoclonal antibody (mAb)-based immunotherapies have achieved promising outcomes in the treatment of immunological and oncological indications. CD19 is considered one most qualified antigens B-cell neoplasms. VHHs (nanobodies) are known for their physicochemical advantages over conventional mAbs rendering them suitable therapeutics diagnostic tools. Herein, we aimed to isolate CD19-specific from a novel immune library using phage display. Methods An VHH gene was...
Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation overexpression of NCL are related to various pathologic oncological indications. These characteristics make it an ideal target for the treatment cancers. AS1411 synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows considerably high affinity NCL, therefore, being capable inducing growth inhibition...