A5085238045- Hormonal Regulation and Hypertension
- Menopause: Health Impacts and Treatments
- Nitric Oxide and Endothelin Effects
- Estrogen and related hormone effects
- Cardiovascular Health and Disease Prevention
- Cardiac Fibrosis and Remodeling
- Protein Hydrolysis and Bioactive Peptides
- Antioxidant Activity and Oxidative Stress
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Endometriosis Research and Treatment
- Cynara cardunculus studies
- Cardiac Health and Mental Health
- Probiotics and Fermented Foods
- Hydrogen's biological and therapeutic effects
- Cardiovascular and exercise physiology
- Diet, Metabolism, and Disease
- Cardiac Ischemia and Reperfusion
- Sulfur Compounds in Biology
- Cardiovascular Disease and Adiposity
- Renal and Vascular Pathologies
- Paraoxonase enzyme and polymorphisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Biochemical Analysis and Sensing Techniques
- Eicosanoids and Hypertension Pharmacology
- Cardiac Valve Diseases and Treatments
Universidade Federal do Espírito Santo
2014-2022
The aim of this study was to evaluate whether exercise training (ET) prevents or minimizes cardiac dysfunction and pathological ventricular remodeling in ovariectomized rats subjected myocardial infarction (MI) examine the possible mechanisms involved process. Ovariectomized Wistar were either MI fictitious surgery (Sham) randomly divided into following groups: Control, OVX+SHAMSED, OVX+SHAMET, OVX+MISED OVX+MIET. ET performed on a motorized treadmill (5x/wk, 60 min/day, 8 weeks). Cardiac...
Drospirenone (DRSP) is a progestin with anti-aldosterone properties and it reduces blood pressure in hypertensive women. However, the effects of DRSP on endothelium-dependent coronary vasodilation have not been evaluated. This study investigated combined therapy estrogen (E2) bed ovariectomized (OVX) spontaneously rats. Female rats (n=87) at 12 weeks age were randomly divided into sham operated (Sham), OVX, OVX treated E2 (E2), (E2+DRSP) groups. Hemodynamic parameters directly evaluated by...
Estrogen deficiency and hypertension are considered major risk factors for the development of coronary heart disease. On other hand, exercise training is an effective form to prevent treat cardiovascular diseases. However, effects swimming (SW) on vascular reactivity in female ovariectomized hypertensive rats not known. We aimed evaluate SW endothelium-dependent vasodilation rats. Three-month old spontaneously (SHR, n=50) were divided into four groups: sham (SH), plus (SSW), (OVX), (OSW)....
There is an increase in the incidence of cardiovascular events such as myocardial infarction (MI) after menopause. However, use oestrogen therapy (E2) remains controversial. The aim this study was to evaluate effects E2, alone and combined with exercise training (ET), on cardiac function remodelling ovariectomised (OVX) rats MI. Wistar female underwent ovariectomy, followed by MI induction were separated into 5 groups: S; MI; MI+ET; MI+E2 MI+ET+E2. Fifteen days or sham surgery, treadmill ET...
Stanozolol is a steroid that causes lipid deposition in LDLr-/- mice, although the mechanism by which this dyslipidemia results cardiac dysfunction little understood. The aim of study was to evaluate effect stanozolol on contractility and participation myocardial phospholamban (pPLB) phosphorylation an atherosclerosis mouse model. LDL receptor knockout mice (LDLr-/-) were fed standard chow diet received weekly subcutaneous injections either saline (control, C group) or 20 mg/kg (S group)....
The aim of this study was to evaluate the effects exercise training (ET) on aortic vascular reactivity ovariectomized and infarcted rats. animals were divided into 5 groups: Control, Ovariectomized + SHAM sedentary (OVX+SHAMSED), OVX+SHAM ET (OVX+SHAMET), OVX Myocardial Infarction (OVX+MISED), MI (OVX+MIET). protocol (60 minutes/day, 5x/week) in a motorized treadmill began 15 days after lasted 8 weeks. endothelium-dependent endothelium-independent evaluated as well role reactive oxygen...
To evaluate the effects of exercise training (ET) on cardiac dysfunction and ventricular remodeling in ovariectomized (OVX) rats subjected to myocardial infarction (MI) possible mechanisms involved. OVX Wistar were MI or Sham surgery divided Control, OVX+SHAM SED , ET OVX+MI groups. was performed a treadmill (5x/wk, 60 min/day, 8 weeks). Cardiac function assessed by catheterization DHE fluorescence evaluated analyze oxidative stress. Collagen deposition, myocyte hypertrophy infarct size...
To evaluate the effects of exercise training (ET) initiated early or late after myocardial infarction (MI) on cardiac dysfunction and ventricular remodeling in ovariectomized (OVX) rats. OVX Wistar rats were subjected to MI Sham surgery divided SHAM, MI, MI+ET3d MI+ET15d groups. ET was performed a treadmill (5x/wk, 60 min/day, 8 weeks). Cardiac function assessed by catheterization. Collagen deposition, myocyte hypertrophy infarct size histology. Catalase, SOD‐2, Gp91phox AT1 receptor (AT1R)...
This study investigated the effects of combined therapy with E2 and drospirenone (DRSP) on endothelium‐dependent vasodilation coronary bed ovariectomized spontaneously hypertensive rats. Animals were randomly divided into Sham operated (Sham), (OVX), treated (E2) DRSP groups. Hemodynamic parameters evaluated by cannulation femoral artery. Coronary was assessed using isolated hearts. Protein expression eNOS estrogen receptor alpha (ER‐α) Western blotting. Morphometric analyzed histology,...
Estrogen deficiency is detrimental to vascular function. On the other hand, practice of exercise training and estrogen therapy improve However, effects swimming (SW) (ET) on relaxation induced by C‐type natriuretic peptide (CNP) unclear. Our aim was investigate chronic SW ET CNP‐induced in aorta ovariectomized hypertensive rats. The groups were randomly divided into sham (S), sham+SW (SSW), (OVX), ovariectomized+ET (OET), ovariectomized+SW (OSW) ovariectomized+ET+SW (OET+SW). (5 mg...
Renovascular hypertension is characterized by increased angiotensin II and oxidative stress endothelial dysfunction. By acting on multiple targets promoting diverse actions, (Ang II) plays a pivotal role in vascular The purpose of this study was to test whether the administration aliskiren (ALSK) L‐arginine (L‐arg) would restore dysfunction reduce inflammation rat renovascular model. Hypertension induced clipping right renal artery, following five groups were divided: SHAM operated;...
We evaluated whether long‐term kefir treatment affects cardiac function (cardiac contractility and calcium‐handling proteins) sympathetic control in spontaneously hypertensive rats (SHR). Male normotensive (WKYs) SHRs were separated into three groups: treated with milk fermented by the grains of (5%; SHR‐Kefir; oral gavage, 0.3mL/100g daily/9weeks), WKYs milk. At end treatment, direct MAP HR measured via artery catheterization. Hemodynamic parameters (left ventricular (LV) systolic pressure...
AIM: To investigate the effects of hormone replacement therapy with estrogen and progestins on Angiotensin 1-7-mediated vascular reactivity in ovariectomized rats. INTERVENTION(S): Ovariectomy hormonal estradiol, drospirenone plus medroxyprogesterone acetate.RESULT(S): impaired Ang vasodilation, which was prevented by therapies MPA DRSP + E2, to extent that it improved E2 monotherapy. There no difference expression AT1 ECA-2 between groups, but receptor showed increased rats monotherapy...