Introduction: Infections at surgical sites are a major problem all over the world. Pathogens linked to postoperative infections becoming increasingly resistant antibiotics, which presents significant therapeutic challenge for surgeons and raises financial burden placed on patients. The study aimed find prevalence of multidrug resistance among patients with site in tertiary care centre. Methods: A descriptive cross-sectional was conducted from 3 November 2022 2 May 2023 post-operative...

Introduction: Due to the complicated interactions between thyroid gland and liver, hormone dysfunction may affect liver function tests, could be of clinical importance. We aimed compare hepatic parameters hypothyroid euthyroid patients visiting tertiary care center western Nepal.
 Materials Methods: This hospital-based cross-sectional study was conducted among 113 111 patients. After consent, were analyzed using automated analyzers. Mann-Whitney U test, Spearman’s correlation, multiple...

Hyperuricemia in dyslipidemic patients has been addressed as a potential risk factor for cardiovascular disease, because of its association with atherosclerosis and elevated oxidative stress. Hence, the main objective present study was to evaluate effect statins on blood uric acid level being treated dyslipidemia at tertiary care hospital. The comprised 120 who were UCMS-TH's outpatient medicine department over six-month period from December 2022 May 2023. Participants met inclusion criteria...

Background: Reference intervals of any biochemical analyte serve as an invaluable tool in clinical decision making. The IFCC (International Federation Clinical Chemistry) guidelines for determining these values are not feasible some hospital laboratory setting and have led to the development alternative approaches.Aims Objectives: To determine indirect reference serum thyrotropin form records individuals visiting a tertiary care center.Materials Methods: In hospital-record based,...

INTRODUCTION: Dyslipidemia is a modifiable risk factor for cardiovascular diseases (CVDs). Menopause-related hormonal alterations are responsible dyslipidemia. Early identification of such factors aids in the prevention and prompt management CVDs. The current study was done to evaluate prevalence dyslipidemia post-menopausal women compare lipid profiles between pre-menopausal women. MATERIALS AND METHODS: This community-based comparative crosssectional conducted among female population...

INTRODUCTION
 The chronic kidney disease (CKD) patient's calcium phosphate product, alkaline phosphatase (ALP), vitamin-D2 and human growth hormone (hGH) are altered under haemodialysis. This study aimed to evaluate these biochemical variables in conjunction with haemoglobin blood pressure find out their association End Stage Renal Disease (ESRD) patients.
 MATERIAL AND METHODS
 cross-sectional comprised of 104 patients ESRD undergoing estimated glomerular filtration rate...

Background: Diabetes mellitus is a global public health problem, with its prevalence escalating each decade. Serum uric acid said to have strong correlation diabetes and might contribute risk. The present study aimed compare the levels of serum in diabetic, pre-diabetic, non-diabetic patients visiting tertiary care center. Methods: This hospital-based cross-sectional was conducted among 320 medicine OPD Universal College Medical Sciences. Of them, 182 were diabetics, 48 pre-diabetics, 90...

INTRODUCTION: Pan Masala Tobacco (PMT), consumed in smoke and smokeless form, contains various carcinogenic chemicals free radicals. Bilirubin uric acid are said to have both pro- anti-oxidant activities. In this context, we aimed compare the serum levels of bilirubin between PMT users non-users. We also wanted observe pattern consumption among users. MATERIALS AND METHODS: A total 204 participants were enrolled community-based comparative cross-sectional study. The study was conducted...

Introduction: The global burden of thyroid disorders, especially hypothyroidism, is high and increasing. Prevalence studies such disorders are limited in Nepal. aim this study was to find out the prevalence hypothyroidism among patients visiting Department Biochemistry central laboratory a tertiary care centre. Methods: A descriptive cross-sectional conducted from 1 August 2020 31 July 2021 after taking ethical approval Institutional Review Committee (Reference number: UCMS/IRC/054/20)....

Estimation of serum aminotransferase levels play important role in the diagnosis and monitoring hepatic diseases. Studies suggest that patients with chronic kidney disease, especially those under hemodialysis, reference ranges aminotransferases might not be reflective function. Due to this, management liver diseases such becomes quite challenging. This study aims estimate compare hemodialysis healthy controls. Seventy-five undergoing Nepal Medical College Teaching Hospital for at least three...

Introduction: Hypovitaminosis D is a global public health problem affecting approximately one billion people, with particularly high prevalence in South Asia. Several hospital-based studies from Nepal show of hypovitaminosis D. However, large-scale community-based are lacking. The aim the study was to find out among blood samples patients presenting Department Biochemistry tertiary care centre. Methods: A descriptive cross-sectional conducted centre 3 November 2022 30 April 2023 after...

Background: Thyroid function and vitamin D levels may be intricately related. The purpose of the current study was to investigate relationship between thyroid hormones in females attending a tertiary care center western Nepal. Methods: This hospital-based cross-sectional enrolled 300 women advised get test (TFT) were included population. They grouped as euthyroid hypothyroid based on TFT status their serum concentrations measured. Vitamin classified normal, deficient, insufficient using...

INTRODUCTION Various mechanisms suggest changes in hematological profiles of Type 2 Diabetes Mellitus (T2DM) patients. Similarly, alterations have been linked with pathogenic Diabetes. We aim to determine adult MATERIAL AND METHODS This hospital-based cross-sectional study was conducted from March 2020 December at the department Pathology and Biochemistry Universal College Medical Sciences. After ethical clearance (UCMS/IRC/016/20), 90 patients diagnosed T2DM were considered. Both verbal...

Background: Anaemia is characterized by a reduced oxygen-carrying capacity of blood and causes various health problems in people all ages, including pregnant women. The most common cause anemia lack iron the diet. Prevention anaemia requires strict adherence to folic acid supplementation during pregnancy. main objective this study was gather information on prevalence among Methods: cross-sectional conducted 200 postpartum mothers obstetrics ward Universal College Medical Sciences. Eligible...

INTRODUCTION: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and one of the major public health problems in developing countries like Nepal. Despite availability effective treatment regimens, patients must take a combination anti-tubercular drugs for at least six months may endure numerous side effects, making compliance exceedingly difficult to maintain. The primary objective study was assess adherence rate agents find prevalence adverse drug reactions therapy....

Toxic epidermal necrolysis (TEN) is a rare, life-threatening, severe necrolytic exanthematous vesicobullous usually drug-induced, mucocutaneous disease characterized by widespread sloughing of the skin and mucosal surfaces. The most common drugs attributable to cause TEN are antibiotics, anti-inflammatory drugs, chemotherapeutic agents, antivirals, anticonvulsants. evolution accompanied local as well general complications which can range from superinfections multiple organ failure. It utmost...

INTRODUCTIONDiabetes is a metabolic disorder marked by high blood glucose levels, and treatment often requires multiple drugs to achieve adequate glycemic control. In individuals with type 2 diabetes mellitus who do not respond Metformin, doctors may prescribe Dipeptidyl Peptidase-4 inhibitor or Sulphonylurea as potential add-on therapy. The study was conducted compare the efficacy safety of Sulphonylurea. MATERIAL AND METHODSThis an interventional, comparative involving 100 diabetic...

INTRODUCTION COVID-19 is a debilitating disorder affecting lungs with multiple organs. Diabetes mellitus considered as common co-mor- bidity whose impact has not been fully understood. There hypothesis that patients diabetes are at increased risk of severe disease or death due to COVID-19. The main objective the present study was find association (DM) and non-diabetes clinical outcomes. MATERIAL AND METHODS This cross-sectional conducted in hospitalized Universal College Medical Sciences...

INTRODUCTION
 Alcohol dependence is a global problem and rapidly increasing in developing countries. We aimed to analyze the serum levels of vitamin B12 D chronic alcoholic patients their association with parameters liver function.
 MATERIAL AND METHODS
 A cross-sectional study was carried out Universal College Medical Sciences, Bhairahawa, Nepal from March 2020 September on visiting Psychiatric Out Patient Department (OPD) for treatment alcohol dependence. The were...