A5092065350- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
Shahid Beheshti University of Medical Sciences
2023
Abstract Background Approximately 5% of colorectal cancers (CRCs) are hereditary. Lynch syndrome (LS), also known as hereditary nonpolyposis cancer (HNPCC), is the most common form recognized CRC. Although Iran, a developing country, has high incidence CRC, spectrum variants yet to be thoroughly investigated. Aims This study aimed investigate pathogenic and non‐pathogenic in MLH1 MSH2 genes Iranian patients with suspected (sLS). Methods results In present study, 25 peripheral blood samples...
Approximately 5% of colorectal cancers (CRCs) are hereditary. Lynch syndrome (LS), also known as hereditary nonpolyposis cancer (HNPCC), is the most common form recognized CRC. Although Iran, a developing country, has high incidence CRC, spectrum mutations yet to be thoroughly investigated. Therefore, this study aimed investigate pathogenic and non-pathogenic variants in MLH1 MSH2 genes Iranian patients with suspected (sLS). In present study, 25 peripheral blood samples were collected from...
Familial adenomatous polyposis (FAP) is an autosomal dominant colorectal cancer syndrome that characterized by the development of multiple adenomas in colon and rectum with high penetrance rates. This disease has specific features like occurrence pathogenic variations APC gene diverse FAP phenotypes due to region. In this study we aimed evaluate variants exons Iranian patients FAP. A total 35 individuals were referred gastroenterology ward Taleghani Hospital. As aim was germline...