A5040973962- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Wnt/β-catenin signaling in development and cancer
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Congenital gastrointestinal and neural anomalies
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Bioinformatics and Genomic Networks
- RNA regulation and disease
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Colorectal Cancer Surgical Treatments
- Autophagy in Disease and Therapy
Shahid Beheshti University of Medical Sciences
2017-2024
Children's Medical Center
2009-2014
Tehran University of Medical Sciences
2009-2014
Gastric cancer (GC) is the world's second-leading cause of cancer-related mortality, continuing to make it a serious healthcare concern. Even though prevalence GC reduces, prognosis for patients remains poor in terms lack reliable biomarkers diagnose early and predict chemosensitivity recurrence.We integrated gene expression patterns gastric cancers from four RNAseq datasets (GSE113255, GSE142000, GSE118897, GSE130823) Gene Expression Omnibus (GEO) database recognize differentially expressed...
Abstract Background The clinical relevance and prognostic value of tumor‐infiltrating lymphocytes (TILs) as an interplay between malignant cells immune function has been known for decades. On contrary, this potential may be different by T subsets endowed with a function. Colorectal cancer (CRC) is heterogeneous disease suggested biomarkers. So, study was conducted to examine the CD8+ TILs on survival rate CRC independent factor oncogenetic tumor features. Methods With respect this, 281...
The detection of KRAS and BRAF mutations is a crucial step for the correct therapeutic approach predicting epidermal growth factor receptor (EGFR)-targeted therapy resistance colorectal carcinomas. concomitant occur rarely in cancers (CRCs) with prevalence less than 0.001% cases. In patients KRAS-mutant tumors, should not regularly be tested unless patient participating clinical trial enriching presence or BRAF-mutated tumor. current report demonstrates case advanced adenocarcinoma colon...
Abstract Background The feces of colorectal cancer (CRC) patients contain tumor colonocytes, which constantly shed into the lumen area. Therefore, stool evaluation can be considered as a rapid and low‐risk way to directly determine colon rectum status. As long non‐coding RNAs (lncRNAs) alterations are important in cells fate regulation, we aimed assess level panel cancer‐related lncRNAs fecal colonocytes. Methods population study consisted 150 subjects, including training set, validation...
Differential expression profile of microRNAs (miRNAs) could be a diagnosis signature for monitoring gastric cancer (GC) progression. In this study, we focus on the comparison levels miR-21, miR-25, miR-93, miR-106b, and miR-375 during sequential pattern GC development, including normal gastric, dysplasia, sample.We used SYBR Green-based quantitative-PCR to quantify miRNAs expression.Our analysis revealed increased miR-21 (p = 0.034), miR-25 0.0003), miR-93 0.0406), miR-106b 0.023) in...
Several serious attempts to treat colorectal cancer have been made in recent decades. However, no effective treatment has yet discovered due the complexities of its etiology.we used Weighted Gene Co-expression Network Analysis (WGCNA) identify key modules, hub-genes, and mRNA-miRNA regulatory networks associated with CRC. Next, enrichment analysis modules performed using Cluepedia. quantitative real-time PCR (RT-qPCR) was validate expression selected hub-genes CRC tissues.Based on WGCNA...
Despite many efforts to discover the important role of autophagy process in pathogenesis colorectal cancer (CRC), exact involved molecular mechanism still remains be elucidated. Recently, a limited number studies have been employed impact genes' variants on development and progression CRC. Here, we evaluated association between two single-nucleotide polymorphisms (SNPs) main components genes, ATG16L1 rs2241880, ATG5 rs1475270, CRC risk an Iranian population.During this investigation, total...
Colorectal cancer (CRC) is considered one of the most common malignancies worldwide. The diagnosis and prognosis patients are very poor. In this study, we used in-silico analysis experimental techniques to investigate novel co-expression genes their associated miRNA networks in CRC. For purpose, conducted a comprehensive transcriptome using online bulk single-cell RNA-seq datasets. We then validated results on tissue samples from cancerous adjacent normal tissues CRC by RT-qPCR.Using...
This study aims to comprehensively delineate the phenotypic spectrum of ACTL6B-related disorders, previously associated with both autosomal recessive and dominant neurodevelopmental disorders. Molecularly, role nucleolar protein ACTL6B in contributing disease has remained unclear.
Familial adenomatous polyposis (FAP) is an autosomal dominant colorectal cancer syndrome that characterized by the development of multiple adenomas in colon and rectum with high penetrance rates. This disease has specific features like occurrence pathogenic variations APC gene diverse FAP phenotypes due to region. In this study we aimed evaluate variants exons Iranian patients FAP. A total 35 individuals were referred gastroenterology ward Taleghani Hospital. As aim was germline...