A5021373781- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Biopolymer Synthesis and Applications
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Hippo pathway signaling and YAP/TAZ
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Wnt/β-catenin signaling in development and cancer
- Celiac Disease Research and Management
- Gastric Cancer Management and Outcomes
- Bioactive natural compounds
- SARS-CoV-2 detection and testing
- Bone Metabolism and Diseases
- Thyroid Disorders and Treatments
- Phytochemicals and Medicinal Plants
- Orthopaedic implants and arthroplasty
- Kruppel-like factors research
- Electrophoretic Deposition in Materials Science
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and healthcare impacts
Birjand University of Medical Sciences
2021-2025
University of Sistan and Baluchestan
2015-2025
Shiraz University of Medical Sciences
2023
Yasuj University of Medical Sciences
2015-2017
University of Kashan
2017
Gastric cancer (GC) is the world's second-leading cause of cancer-related mortality, continuing to make it a serious healthcare concern. Even though prevalence GC reduces, prognosis for patients remains poor in terms lack reliable biomarkers diagnose early and predict chemosensitivity recurrence.We integrated gene expression patterns gastric cancers from four RNAseq datasets (GSE113255, GSE142000, GSE118897, GSE130823) Gene Expression Omnibus (GEO) database recognize differentially expressed...
Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat number of cancers has been reported most likely induce testicular toxicity. Administration antioxidants, such pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) CDDP. Therefore, this study investigated the potentially protective effects PTX on CDDP-induced toxicity in adult rats. For purpose, 42 rats were randomly divided into 7...
The Hippo signaling system plays a vital role in controlling cell proliferation, apoptosis, and organ size. Disruption of this pathway strongly correlates with the growth progression hepatocellular carcinoma (HCC). Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) long noncoding (lncRNAs), play crucial regulating have significant impact on different aspects liver tumor development. This paper thoroughly investigates functions ncRNAs pathway, specifically cancer. We examine how certain...
Resistance to trastuzumab has become a limiting factor for therapeutic efficacy of human epidermal growth 2 (HER2)-positive breast cancer. Different expression levels miRNAs in cancer cells have been associated with poor prognosis and response chemotherapy. The aim this study was evaluate that were thought be HER2-positive chemoresistance. In study, the relative candidate U6 RNA evaluated trastuzumab-resistant trastuzumab-sensitive using real-time PCR. Our results demonstrated miR-23b-3p,...
Abstract Background The outbreak of Coronavirus in late 2019 and its continuation the following years has affected all human societies, government organizations, health systems. Access to services is an important issue during crises. present study aimed investigate effect Covid-19 pandemic on consumption public sector compared private Iran. Methods research population consisted insured individuals covered by Iran Health Insurance Organization Fars province, which amounts approximately...
Several serious attempts to treat colorectal cancer have been made in recent decades. However, no effective treatment has yet discovered due the complexities of its etiology.we used Weighted Gene Co-expression Network Analysis (WGCNA) identify key modules, hub-genes, and mRNA-miRNA regulatory networks associated with CRC. Next, enrichment analysis modules performed using Cluepedia. quantitative real-time PCR (RT-qPCR) was validate expression selected hub-genes CRC tissues.Based on WGCNA...
MicroRNA-98 (miR-98) stands as an important molecule in the intricate landscape of oncology. As a subset microRNAs, these small non-coding RNAs have accompanied new era cancer research, underpinning their significant roles tumorigenesis, metastasis, and therapeutic interventions. This review provides comprehensive insight into biogenesis, molecular properties, physiological undertakings miR-98, highlighting its double-edged role progression-acting both tumor promoter suppressor....
Cancer therapies using defects in homologous recombination (HR) DNA repair pathway of tumor cells are not yet approved to be applicable patients with malignancies other than BRCA1/2-mutated tumors. This study was designed determine the efficacy combination therapy a histone deacetylase inhibitor, valproic acid (VPA) and novel PARP inhibitor AZD2461 both PC-3 (PTEN-mutated) DU145 (PTEN-unmutated) prostate cancer cell lines. The Trypan blue dye exclusion assay tetrazolium-based colorimetric...
Datura innoxia (D. innoxia) has an extensive usage in traditional medicine and can also be used for intervention therapy order to treat cancer. Despite of accomplishing some researches on D. mechanism, still our knowledge is very little about exact apoptotic mechanism human chronic myeloid leukemia cells (K562 cells). This study purpose was clarify the molecular apoptosis, which mediated by leaves aqueous extract K562 cells. MTT assay flow cytometry applied assess viability apoptosis...
Colorectal cancer (CRC) is considered one of the most common malignancies worldwide. The diagnosis and prognosis patients are very poor. In this study, we used in-silico analysis experimental techniques to investigate novel co-expression genes their associated miRNA networks in CRC. For purpose, conducted a comprehensive transcriptome using online bulk single-cell RNA-seq datasets. We then validated results on tissue samples from cancerous adjacent normal tissues CRC by RT-qPCR.Using...
Cancer continues to pose a major global health challenge due its high mortality rates and increasing incidence. MicroRNAs (miRNAs), which are small non-coding RNAs regulating gene expression at the post-transcriptional level, pivotal in development of cancer, serving either as oncogenes or tumor suppressors. miR-18b has become involved number cancers been shown perform both tumor-suppressive carcinogenic activities. This review examines biogenesis, molecular mechanisms, functional roles...
In this study, we aimed to investigate the effect of co-treatment with apigenin and doxorubicin (DOX) on K562 cells. Our results show that (0, 40, 60, 80 ,100 µM) DOX (0-10 as single therapy, could decrease cell viability (after 24 h treatment) in a dose-dependent manner. Additionally, (60, 10 µM led greater reduction growth (CI: 0.92 0.97) after treatment compared (p < 0.05). Consequently, DOX, either or (24 treatment), were indicated induce apoptosis cells through morphological studies,...
Oxidative stress plays an important role in the pathology of thyroid disorders. This study examined effect gallic acid (GA) on oxidative status and expression liver antioxidant genes including thioredoxin (TXN1 & TXN2) reductase1 (TXNRd1) hypo- hyperthyroid rat models. Forty-nine male Wistar rats were randomly assigned into seven groups as follows: control group, hypothyroid respectively induced by propylthiouracil levothyroxine, hyper thyroid-treated (where separately treated with 50 100...