A5017670864- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Neutropenia and Cancer Infections
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Bee Products Chemical Analysis
- Chemotherapy-related skin toxicity
- MicroRNA in disease regulation
- Cancer survivorship and care
- Iron oxide chemistry and applications
- Silymarin and Mushroom Poisoning
- Chemotherapy-induced cardiotoxicity and mitigation
- RNA modifications and cancer
- Digestive system and related health
- Circular RNAs in diseases
- Clinical Reasoning and Diagnostic Skills
- Phytochemistry Medicinal Plant Applications
- Heavy Metal Exposure and Toxicity
- Fibroblast Growth Factor Research
Mashhad University of Medical Sciences
2014-2024
Emam Reza Hospital
2016-2022
Imam Reza Hospital
2015-2020
Stem Cell Technology Research Center
2009
Tehran University of Medical Sciences
2009
Hand–foot syndrome (HFS) is a frequent dose‐limiting adverse reaction of capecitabine in patient with gastrointestinal cancers. Silymarin polyphenolic flavonoid extracted from the Silybum marianum that exhibits strong antioxidant and antiinflammatory activities. In this study, we evaluated silymarin efficacy prevention capecitabine‐induced HFS patients cancers, as first human study. During pilot, randomized, double‐blinded, placebo‐controlled clinical trial, effect gel 1%, which applied on...
Abstract Purpose Colorectal cancer (CRC) is one of the common cancers with a high mortality rate worldwide. In Iran, there has been trend increased incidence colorectal in last three decades that necessitates early diagnosis. Genetic factors have an influential role its etiology along conventional risk such as age, diet, and lifestyle. Results from GWAS shown significant associations between SMAD7 gene variants CRC. This study aimed to assess association certain polymorphisms well haplotypes...
Background: Today, the role of microRNAs in pathogenesis breast cancer has been established. Genetic mutations play a significant determining risk factors cancer. The polymorphism these two genes can alter their expression. This study performed to investigate relationship between polymorphisms rs6715345 miR-375 gene and rs4939827 SMAD7 development population southeastern Iran. Methods: case-control was on blood sample 205 patients with 200 healthy individuals for investigating rs34917480...
Purpose Neuropathy is one of the most prevalent and dose-limiting side effects platinum chemotherapeutic agents. N-acetylcysteine an antioxidant thiol which able to increase whole blood concentration glutathione, may be protective against chemotherapy-induced neuropathy. The aim this study was evaluate effect on neurotoxicity induced by oxaliplatin in patients with gastric or colorectal cancers. Methods During randomized, double‐blinded, placebo‐controlled clinical trial, preventive...
The purpose of this study was to compare the efficacy and safety a proposed bevacizumab biosimilar those reference product in patients with metastatic colorectal cancer (mCRC).This Phase III, multicenter, randomized, double-blind (patient- assessor-blind), active-controlled, 2-armed, parallel-group, noninferiority trial conducted histologically verified evidence at least 1 metastasis. Patients mCRC were randomized 2:1 receive 5 mg/kg IV either drug plus FOLFIRI-3 (with repeated irinotecan...
Acute myeloid leukemia (AML) is a clonal hematopoietic disorder resulting from genetic alterations in normal stem cells. The aim of this study was to evaluate prognostic factors and survival AML patients the Northeast Iran.This retrospective covered 96 with referred Emam Reza Hospital, Mashhad city, Iran, 2009 2015. Age, sex, blood group, type AML, fever, consumption amphotericin B, cytogenetic forms were analyzed. Also, WBC, hemoglobin platelet levels checked. Mean follow-up 30.5 months...
Abstract Background This study compared efficacy and safety of TA4415V, a trastuzumab biosimilar, with reference in patients human epidermal growth factor receptor 2 – positive (HER2-positive) early-stage breast cancer treated the neoadjuvant setting Iran. Methods Patients were randomly assigned to receive TA4415V or concurrently docetaxel (TH phase) for 4 cycles after treatment doxorubicin cyclophosphamide (AC phase). Chemotherapy was followed by surgery. The primary endpoint comparison...
The present study aimed to evaluate the relationship between serum N-terminal (NT)-pro-brain natriuretic peptide (BNP) levels and incidence of left ventricular (LV) systolic diastolic dysfunction in patients who underwent low-dose anthracycline chemotherapy.
Introduction. Today, breast cancer patients suffer from various psychological symptoms that impose irreversible effects on their quality of life. The aim the present study was to determine prevalence depression, anxiety, and stress in with cancer. Material methods. This descriptive performed 190 women January 1, 2019 July 30, 2019. Data collection carried out using a convenience sampling method. Standard Depression, Anxiety, Stress Scale (DASS-21) used assess stress. Results. mean age 46.3...
Abstract Background Breast cancer is the most frequently diagnosed and leading reason for cancer-related death among women. Neoadjuvant treatment with dual-HER2 (human epidermal growth factor receptor 2) blockade has shown promising effects in this regard. The present study aimed to compare efficacy safety of a proposed pertuzumab biosimilar reference pertuzumab. Methods This randomized, phase III, multicenter, equivalency clinical trial was conducted on chemotherapy-naive women...
Background: Zinc (Zn) and Selenium (Se) are trace minerals that have high anti-cancer chemopreventive properties. Objectives: This study aimed at evaluating the serum levels of both elements in women with breast cancer (BC) compared control group correlation them risk factors BC. Methods: In a case-control study, 142 BC 158 healthy controls, aged 19 to 88 years, were selected. Both groups did not use any type supplement 3 months before participation study; there was no history chronic kidney...
Acute lymphoblastic leukemia (ALL) is aggressive cancer, especially in adults as only 20-40% cured with current treatment regimens.The aim of this study to evaluate prognostic factors and their effects on survival ALL patients the Northeast Iran.In a descriptive retrospective from 2009 2015, 48 referred hematology-oncology clinic. Age, sex, fever, blood group, type consumption amphotericin B, forms cytogenetic, patients, WBC, hemoglobin, platelet were checked first referral for every...
Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests squamous cells in spindle cell background. Furthermore, its occurrence following AML also rare. To best our knowledge, based on review relevant literature, thus far there have not been any welldocumented cases. In present case report, we report middle-aged woman 2year history acute myeloid leukemia (AML) who was admitted to hospital due mass right breast, concurrent cutaneous...
<title>Abstract</title> Background and Aim: The significance of morning report sessions has prompted medical universities, faculties, clinical groups to pursue suitable standards criteria for conducting these at the highest possible quality. Numerous factors have had a significant impact on competencies satisfaction levels interns, residents, faculty members with regard execution sessions. This study aimed investigate compare educational students participating in In this perspectives...
Abstract Background: Epstein–Barr virus (EBV) is a DNA from human herpes that associates with many of the cancers including gastric cancer (GC). Aims: The aim present study was to report infection EBV in adult patients GC Northeast Iran and correlation between number clinicopathology factors status. Materials Methods: In case–control 2016, 56 controls were selected for analysis. All had adenocarcinoma untreated age >18 years. status detected by polymerase chain reaction method. Results:...