A5062390320- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ubiquitin and proteasome pathways
- PARP inhibition in cancer therapy
- Atherosclerosis and Cardiovascular Diseases
- Vitamin C and Antioxidants Research
- Hemoglobinopathies and Related Disorders
- Endoplasmic Reticulum Stress and Disease
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- Nutrition, Genetics, and Disease
Max Planck Institute for Heart and Lung Research
2021-2024
Shahid Beheshti University of Medical Sciences
2017-2019
Significance We discovered that the histone/protein deacetylase SIRT7, which is only member of mammalian sirtuin family residing primarily in nucleolus, stabilizes p53 response to UV-induced DNA damage by enabling binding deacetylated NPM MDM2/HDM2. The study unveils a crucial mechanism nucleolus controls cellular stress responses. Furthermore, it characterizes SIRT7 as potent regulator and offers opportunities manipulate levels, important for development antitumor therapies.
Sirtuin 7 (SIRT7) is a member of the mammalian family nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylases, known as sirtuins. It acts potent oncogene in numerous malignancies, but molecular mechanisms employed by SIRT7 to sustain lung cancer progression remain largely uncharacterized. We demonstrate that exerts oncogenic functions cells destabilizing tumor suppressor alternative reading frame (ARF). directly interacts with ARF and prevents binding nucleophosmin,...
Differential expression profile of microRNAs (miRNAs) could be a diagnosis signature for monitoring gastric cancer (GC) progression. In this study, we focus on the comparison levels miR-21, miR-25, miR-93, miR-106b, and miR-375 during sequential pattern GC development, including normal gastric, dysplasia, sample.We used SYBR Green-based quantitative-PCR to quantify miRNAs expression.Our analysis revealed increased miR-21 (p = 0.034), miR-25 0.0003), miR-93 0.0406), miR-106b 0.023) in...
p53 is a hallmark tumor suppressor due in part to its role cell cycle progression, DNA damage repair, and cellular apoptosis; protein activity interrelates with the Sirtuin family of proteins, major regulators response metabolic, oxidative, genotoxic stress. In recent years, mammalian 7 (SIRT7) has emerged as pivotal regulator p53, fine-tuning context dependent manner. SIRT7 frequently overexpressed human cancer, yet precise tumorigenesis whether it involves regulation insufficiently...
Giant cell arteritis (GCA), medium and large vessel granulomatous vasculitis affecting the elderly, is characterized by a multitude of vascular complications, including venous thrombosis, myocardial infraction stroke. The formation infiltrates enhanced accumulation proinflammatory cytokines are typical features this condition. GCA pathogenesis remains largely unknown, but recent studies have suggested involvement oxidative stress, mainly sustained an reactive oxygen species (ROS) production...
Idiopathic pulmonary fibrosis (IPF) represents the most aggressive form of (PF) and is a highly debilitating disorder with poorly understood etiology. The lung epithelium seems to play critical role in initiation progression disease. A repeated injury epithelial cells prompts type II alveolar secrete pro-fibrotic cytokines, which induces differentiation resident mesenchymal stem into myofibroblasts, thus promoting aberrant deposition extracellular matrix (ECM) formation fibrotic lesions....
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating ultraviolet irradiation, indicating tumor-suppressive functions SIRT7.
Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial disorders in Iran. Recent genome wide association studies (GWASs) and functional have suggested that WFS1 may predispose individuals to T2DM. However, date, possible such variants with T2DM Iranians remained unknown. Here, we investigated two polymorphisms (rs1801214 a CpG-SNP, rs1046320 3'UTR-SNP) an Iranian population. The study population comprised 432 unrelated including 220 patients T2DM, 211 healthy control...
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ARF) within nucleolus, aiding progression. We propose targeting offers promise for new anti-cancer therapies.
miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In following study we analyzed expression miR-7 samples compared non-tumor tissues and dysplasia (GD) with patients’ clinico-pathological data its potential diagnostic biomarker. We first by real-time qRT– PCR human GD GC tissues, which it was greatly downregulated each control tissues. The current supports participation miRNA miR-7-5p highlights their