A5000950786- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Advanced Glycation End Products research
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- TGF-β signaling in diseases
- Aortic aneurysm repair treatments
- Marriage and Sexual Relationships
- Blood Pressure and Hypertension Studies
- Adenosine and Purinergic Signaling
- Neurological Disorders and Treatments
- Dialysis and Renal Disease Management
- Infective Endocarditis Diagnosis and Management
- Plant-derived Lignans Synthesis and Bioactivity
- Neurological Complications and Syndromes
- Bipolar Disorder and Treatment
- Sepsis Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Neonatal Health and Biochemistry
- Parathyroid Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Mayo Clinic
1998-2013
WinnMed
2000-2013
Mayo Clinic in Arizona
2005-2012
National Institute of Diabetes and Digestive and Kidney Diseases
2011
National Institutes of Health
2011
State Street (United States)
2007
University of Minnesota Rochester
2007
University of Tübingen
1995
Pirfenidone is an oral antifibrotic agent that benefits diabetic nephropathy in animal models, but whether it effective for human unknown. We conducted a randomized, double-blind, placebo-controlled study 77 subjects with who had elevated albuminuria and reduced estimated GFR (eGFR) (20 to 75 ml/min per 1.73 m²). The prespecified primary outcome was change eGFR after 1 year of therapy. randomly assigned 26 placebo, pirfenidone at 1200 mg/d, 25 2400 mg/d. Among the 52 completed study, mean...
The role of sodium bicarbonate in preventing contrast nephropathy needs to be evaluated clinical settings.We performed a retrospective cohort study at Mayo Clinic Rochester, Minnesota, assess the risk associated with use bicarbonate, N-acetylcysteine, and combination N-acetylcysteine from April 2004 May 2005. Contrast was defined as postexposure creatinine elevation > or =25% >0.5 mg/dl within 7 d exposure.A total 11,516 exposures 7977 patients had values available for review before after...
ANG II induces vasoconstriction, at least in part, by stimulating NADPH oxidase and generating reactive oxygen species. also heme oxygenase activity, bilirubin, a product of such possesses antioxidant properties. We hypothesized that because its properties, may reduce the pressor prooxidant effects II. Our vivo studies used hyperbilirubinemic Gunn rat which is deficient enzyme uridine diphosphate glucuronosyl transferase, latter enabling excretion bilirubin into bile. (0.5 mg x kg(-1)...
Adenosine (ADO) has been implicated as a pathophysiological factor in contrast media (CM)-induced acute renal failure, which encountered more often patients with diabetes and impaired function. Therefore, we studied the vascular response to exogenous endogenous ADO streptozotocin-induced diabetic rats. We found that (0.01–100 nmol), injected into abdominal aorta, decreased blood flow (RBF) dose-dependent manner. The dose-response curve was shifted left by 30 diabetic, compared nondiabetic...
In rats with streptozotocin (STZ)-induced diabetes, the renal vasoconstrictor effect of adenosine is enhanced. We investigated role nitric oxide (NO) in vascular response to exogenous and endogenous control STZ diabetic rats. Exogenous (0.01–100 nmol) injected into abdominal aorta decreased blood flow (RBF) a dose-dependent manner much greater extent than ( P < 0.001). Inhibition NO synthesis N ω -nitro-l-arginine (l-NNA, 30 μmol/kg iv) perfusion pressure controlled potentiated...
The role of nitric oxide (NO) in the regulation intrarenal microcirculation streptozotocin (STZ)-induced diabetes mellitus rats is not clear. We examined renal cortical and papillary hemodynamics STZ determined effects systemic inhibition stimulation NO synthesis. Renal blood flow (Q CC ), inner medullary ascending AV ) descending DV vasa recta capillaries was measured by fluorescence videomicroscopy Munich-Wistar nondiabetic control rats. Ten days after injection (80 mg/kg ip), basal Q were...
We investigated the role of prostaglandins in renal vascular response to exogenous and endogenous adenosine control streptozotocin (STZ) diabetic rats. Exogenous (0.01–100 nmol) injected into abdominal aorta decreased blood flow (RBF) a dose-dependent manner much greater extent STZ rats than ( P < 0.001). Inhibition prostaglandin synthesis with indomethacin (Indo; 10 mg/kg iv) potentiated adenosine-induced vasoconstriction but not In rats, Indo shifted dose curve RBF reductions left by...
Purpose: To compare the clinical outcomes in patients with chronic renal insufficiency (CRI) and artery stenosis (RAS) following (RA) stent placement without embolic protection device (EPD) usage. Materials Methods: Eighteen who had RA EPD were matched to control (RA only). Blood pressure, number of hypertensive medications, estimated glomerular filtration rate (eGFR) at 3 months before procedure after 12 determined. An increase ≥ 20% eGFR from baseline was defined as “improvement,” decrease...
We previously demonstrated an increased sensitivity of the renal vasculature to adenosine (ADO) mediated via ADO A 1 receptors in streptozotocin (STZ) diabetic rats. Because stimulates P i reabsorption proximal tubule, present study was performed determine whether tubular system antiphosphaturic effect is enhanced STZ Clearance studies were performed, and infused into interstitium implanted matrices STZ- control (Con) rats mimic effects endogenous ADO. Renal phosphate excretion significantly...