A5070965834- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Mass Spectrometry Techniques and Applications
- Cancer Treatment and Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cardiomyopathy and Myosin Studies
- Paleontology and Evolutionary Biology
- Muscle Physiology and Disorders
- Cardiovascular Function and Risk Factors
- Chemical Reactions and Isotopes
- Paleontology and Stratigraphy of Fossils
- Protein Structure and Dynamics
- Lipid Membrane Structure and Behavior
- Geological and Geophysical Studies
- Electron Spin Resonance Studies
- Protein Kinase Regulation and GTPase Signaling
- Neural dynamics and brain function
- Spectroscopy and Quantum Chemical Studies
- Circadian rhythm and melatonin
- Radiopharmaceutical Chemistry and Applications
Stanford University
2014-2020
The β2 adrenergic receptor (β2AR) is an archetypal G protein coupled (GPCR). One structural signature of GPCR activation a large-scale movement (ca. 6 to 14 Å) transmembrane helix (TM6) conformation which binds and activates cognate protein. β2AR exhibits low level agonist-independent activation. origin this basal activity its suppression by inverse agonists unknown but could involve unique that promotes Alternatively, conformational selection model proposes minor population the canonical...
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across varied brain cell types has not been extensively characterized, especially with agonists. This study reports a pharmacological analysis of AR function, offering insights for innovative therapeutic interventions that might serve to compensate decline, known develop in earliest phases neurodegenerative diseases. First, β-AR agonist...
Increased myocardial stiffness is a hallmark of impaired diastole in heart failure (HF). Hypo-phosphorylation the N2B unique sequence (N2Bus) titin (TTN), giant myofilament protein, increases passive tension leading to diastolic dysfunction HF. Enhancing altered N2Bus phosphorylation improves cardiac and function. FHL-1, an interacting protein potentially modulating increased FHL-1 knockout mice display blunted hypertrophy improved compliance response pressure-overload by transverse aortic...
G protein‐coupled receptors (GPCRs) translate extracellular ligand binding into intracellular signaling responses via allosteric communication between two distant sites. For many GPCRs, agonists and proteins has been observed in the form of protein‐mediated enhancement agonist affinity. However, mechanism by which allosterically regulate a receptor's orthosteric site remained unclear. Based on recent crystal structures β 2 ‐adrenergic receptor (β AR), we hypothesized that stabilization an...