A5049680777- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Viral Infections and Vectors
- interferon and immune responses
- Hip and Femur Fractures
- Blood disorders and treatments
- Diaspora, migration, transnational identity
- Migration, Ethnicity, and Economy
- Cerebral Palsy and Movement Disorders
- Lipid metabolism and biosynthesis
- Bone and Joint Diseases
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Migration and Labor Dynamics
- Animal Virus Infections Studies
- Lung Cancer Treatments and Mutations
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Renal function and acid-base balance
- Systemic Sclerosis and Related Diseases
- Bone health and osteoporosis research
- Long-Term Effects of COVID-19
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Frailty in Older Adults
University of Hong Kong
2022-2025
Trinity Health
2025
Kern Medical Center
2021
Sydney Children’s Hospitals Network
2019
UNSW Sydney
2019
University College London
2012-2015
Royal Brompton Hospital
2014
Imperial College London
2014
Harvard University Press
2010
Indiana University
2006
Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment.To perform a comprehensive prospective characterization wasting, defining the pathogenic roles altered protein synthesis and breakdown.Sixty-three critically ill patients (59% male; mean age: 54.7 years [95% CI, 50.0-59.6 years]) an Acute Physiology Chronic Health Evaluation II score 23.5 (95% 21.9-25.2) were prospectively recruited within 24 hours following intensive care unit (ICU)...
Puthucheary, Zudin A.; Rawal, Jaikitry; Mcphail, Mark; Connolly, Bronwen; Ratnayake, Gamunu; Chan, Pearl; Hopkinson, Nicholas S.; Padhke, Rahul; Dew, Tracy; Sidhu, Paul Velloso, Cristiana; Seymour, John; Agley, Chibeza C.; Selby, Anna; Limb, Marie; Edwards, Lindsay M.; Smith, Kenneth; Rowlerson, Anthea; Rennie, Michael Moxham, Harridge, Stephen D. R.; Hart, Nicholas; Montgomery, Hugh E. Author Information
Mpox virus (MPXV) has to establish efficient interferon (IFN) antagonism for effective replication. MPXV-encoded IFN antagonists have not been fully elucidated. In this study, the of poxin-schlafen (PoxS) fusion gene MPXV was characterized. PoxS capable decreasing cGAS-produced 2′3′-cGAMP, like its ortholog poxin vaccinia virus, which is first known cytosolic nuclease that hydrolyzes 3′-5′ bond 2′3′-cyclic GMP-AMP (cGAMP). However, did suppress cGAS-STING-mediated type I production. Instead,...
Acute skeletal muscle wasting is a major contributor to post critical illness physical impairment. However, the bone response remains uncharacterized. We prospectively investigated early changes in mineral density (BMD) and fracture risk illness.Patients were recruited ≤24 hours following intensive care unit (ICU) admission university teaching or community hospital (August 2009 April 2011). All aged >18 years expected be intubated for >48 hours, spend >7 days survive ICU admission. Forty-six...
One of the primary targets immune checkpoint inhibition is negative regulatory molecule CTLA-4. Immune-related adverse events are commonly observed following CTLA-4 in melanoma treatment, and a spectrum these conditions also individuals with germline haploinsufficiency CTLA4. Here we describe heterozygous de novo missense variant CTLA4 young girl childhood-onset autoimmune hepatitis polyarthritis, latter responding to treatment CTLA-4-Ig fusion protein. This lay within highly conserved...
Abstract Social service agencies and advocacy groups have played an integral role in mediating between the Asian ethnic populations. In Canadian institutional setting, associations become a means of political expression. Canada incorporates new immigrants into its national institutions. However, these neo‐liberal institutions policies not redressed major problems arising settlement process. Under Canada's discourse enlightened multiculturalism, social are funded to help integrate diverse...
Single-cycle infectious virus can elicit close-to-natural immune response and memory. One approach to generate single-cycle severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is through deletion of structural genes such as spike (S) nucleocapsid (N). Transcomplementation the resulting ΔS or ΔN enforced expression S N protein in cells gives rise a live but unproductive virus. In this study, BAC clones were constructed their virions rescued by transient proteins from ancestral...
Lemierre syndrome was first documented in the literature 1936, and is defined as septic thrombophlebitis of internal jugular vein. It typically a result oropharyngeal infection causing local soft tissue inflammation, which spreads to vasculature, promotes formation thrombi within lumen, persistent bacteremia, emboli. We present case 24-year-old incarcerated man, who presented with leukocytosis right-sided tender, swollen neck after undergoing left mandibular molar extraction for an infected...
<h3>Background</h3> Critical illness survivors demonstrate skeletal muscle wasting with associated functional impairment. We prospectively characterised this process, and defined the pathogenic roles of altered protein synthesis degradation. <h3>Methods</h3> Critically ill patients (n=63, 59% male, age 54.7±18.0 years, APACHE II score 23.5±6.5) were recruited <24 hours following Intensive Care Unit (ICU) admission. Muscle loss trajectory was determined through serial ultrasound...
ABSTRACT Exactly why human infection of avian influenza A virus H7N9 causes more severe disease in the elderly remains elusive. In this study, we found that PB1‐F2 is a pathogenic factor 15–18‐month‐old BALB/C mice (aged mice) but not 6–8‐week‐old young adult (young mice). Recombinant with PB1‐F2‐knockout was less aged as indicated delayed weight loss. contrast, survival infected diminished. Furthermore, tissue damage, inflammation, proinflammatory cytokine and 2′3′‐cGAMP production lung...
<h3>Objectives</h3> To study the bone mineral density (BMD) and body composition (BC) in Chinese patients with systemic sclerosis (SSc), risk factors for low BMD. <h3>Methods</h3> Consecutive who fulfilled ACR criteria SSc were screened BMD BC (fat lean mass) by dual energy X-ray absorptiometry (DXA) scan (Hologic, Belford USA). Exclusion were: (1) Age <18 years; (2) Informed consent could not be obtained. An equal number of age gender matched healthy controls also recruited same...