Charles Brower

ORCID: 0000-0002-9980-9031
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About
Contact & Profiles
Research Areas
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Radiation Dose and Imaging
  • Intestinal and Peritoneal Adhesions
  • Antibiotic Resistance in Bacteria
  • Animal Nutrition and Physiology
  • Hernia repair and management
  • Appendicitis Diagnosis and Management
  • Healthcare cost, quality, practices
  • Intestinal Malrotation and Obstruction Disorders
  • Antibiotics Pharmacokinetics and Efficacy
  • Kidney Stones and Urolithiasis Treatments
  • Law, logistics, and international trade
  • Evolution and Genetic Dynamics
  • International Maritime Law Issues
  • Digital Games and Media
  • Colorectal Cancer Surgical Treatments
  • Gastrointestinal Tumor Research and Treatment
  • International Arbitration and Investment Law
  • Global Maternal and Child Health
  • Pharmacological Effects and Assays
  • Anorectal Disease Treatments and Outcomes
  • Ultrasound in Clinical Applications
  • Malaria Research and Control
  • Advanced X-ray and CT Imaging
  • Abdominal Surgery and Complications

University of Cincinnati
2022-2024

University of Cincinnati Medical Center
2022-2024

Harvard University
2021-2022

Center for Disease Dynamics, Economics & Policy
2014-2017

University of Massachusetts Boston
2017

Leuphana University of Lüneburg
2017

University of Milan
2017

Princeton University
2014

Significance Antimicrobials are used in livestock production to maintain health and productivity. These practices contribute the spread of drug-resistant pathogens both humans, posing a significant public threat. We present first global map (228 countries) antibiotic consumption conservatively estimate total 2010 at 63,151 tons. project that antimicrobial will rise by 67% 2030, nearly double Brazil, Russia, India, China, South Africa. This is likely be driven growth consumer demand for...

10.1073/pnas.1503141112 article EN Proceedings of the National Academy of Sciences 2015-03-19

Agricultural use of antimicrobials in subtherapeutic concentrations is increasing response to the rising demand for food animal products worldwide. In India, production unregulated. Research suggests that many clinically important are used indiscriminately. This largest study date India surveys poultry test antimicrobial resistance and occurrence extended-spectrum β-lactamases (ESBLs) modulated by farming managerial practices.Our goal was survey eleven relevant phenotypic ESBLs as...

10.1289/ehp292 article EN public-domain Environmental Health Perspectives 2017-07-24

The evolution of resistance to antimicrobial chemotherapy is a major and growing cause human mortality morbidity. Comparatively little attention has been paid how different patient treatment strategies shape the resistance. In particular, it not clear whether treating individual patients aggressively with high drug dosages long durations, or moderately low short durations can better prevent spread Here, we summarize very limited available empirical evidence across pathogens provide...

10.1098/rspb.2014.0566 article EN Proceedings of the Royal Society B Biological Sciences 2014-09-24

Rapidly rising incomes are driving demand for animal protein and livestock globally. The move toward more intensive production systems to support this increased is projected increase the dependence on antibiotic growth promoters. volume of antibiotics used promotion in outstrips that disease treatment humans creates significant selection pressure evolution resistance—a challenge global health resource conservation. This review describes benefits costs promoters considers prospects fully...

10.1146/annurev-resource-100814-125015 article EN Annual Review of Resource Economics 2015-07-01

Computed tomography (CT) has long been the gold standard in diagnosing patients with suspected small bowel obstruction (SBO). Recently, point-of-care ultrasound (POCUS) demonstrated comparable test characteristics to CT imaging for diagnosis of SBO. Our primary objective was estimate annual national cost saving impact a POCUS-first approach evaluation secondary objectives were reduction radiation exposure and emergency department (ED) length stay (LOS).We created ran 1000 trials Monte Carlo...

10.1111/acem.14464 article EN Academic Emergency Medicine 2022-02-20

This comparative effectiveness research compares the ability of clinical features vs with computed tomography (CT) to estimate need for small bowel obstruction surgery.

10.1001/jamanetworkopen.2023.41376 article EN cc-by-nc-nd JAMA Network Open 2023-11-02

Research on esports is a relatively new, yet fastgrowing discipline with multiple inter-and multidisciplinary perspectives.For HICSS-56, research was solicited from disciplines, including but not limited to business; cognitive science and psychology; information technology; sociology; media studies communications; law; health, wellness, medical sciences; emerging technology.In total, eleven manuscripts disciplines were received subjected peer editorial review.Of those eleven, five accepted...

10.24251/hicss.2023.474 article EN Proceedings of the ... Annual Hawaii International Conference on System Sciences/Proceedings of the Annual Hawaii International Conference on System Sciences 2024-01-01

10.1016/j.jemermed.2020.11.020 article EN Journal of Emergency Medicine 2021-01-19
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