A5048554136- Cellular transport and secretion
- Protein Kinase Regulation and GTPase Signaling
- Protease and Inhibitor Mechanisms
- Synthesis of Organic Compounds
- Sulfur Compounds in Biology
- Lipoproteins and Cardiovascular Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phytase and its Applications
- Adipose Tissue and Metabolism
- Adenosine and Purinergic Signaling
- Cellular Mechanics and Interactions
- Molecular Sensors and Ion Detection
- Enzyme Structure and Function
- Lanthanide and Transition Metal Complexes
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Plant nutrient uptake and metabolism
- Carbohydrate Chemistry and Synthesis
University of Oxford
2020-2024
Mansfield University
2020
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have elusive. Here we report that disrupts focal adhesion dynamics and cytoskeletal remodeling, which requires 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7). We find inositol hexakisphosphate kinase 1 (IP6K1) binds Arp2 generates 5-InsP7 recruit coronin, a negative regulator Arp2/3 complex. IP6K1 also produces adhesion-enriched 5-InsP7, (FAK) at FERM domain promote its...
Abstract Aims Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin challenges exogenous administration, regulatory mechanisms biosynthesis are significant pharmacological interest. Methods results Here, we report 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) generated by inositol hexakisphosphate kinase 1 (IP6K1) governed levels via thiol-mediated quality control in...
D-myo-inositol 1,4,5-trisphosphate (InsP
The yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase DDP1 is a Nudix enzyme with pyrophosphatase activity on diphosphoinositides, dinucleotides, polyphosphates. These substrates bind to diverse protein targets participate in signaling metabolism, being essential for energy phosphate homeostasis, ATPase pump regulation, or phosphorylation. An exhaustive structural study of complex multiple ligands related its three substrate classes reported. This allowed full...
We report the first molecular probe for selective detection of most abundant cellular inositol pyrophosphate 5-PP-InsP 5 , supported by computational chemistry, as well an efficient new synthesis.
Chiral sugar derivatives are potential cyclitol surrogates of the Ca2+-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Six novel polyphosphorylated analogues derived from both d- and l-glucose were synthesized. Binding to Ins(1,4,5)P3 receptors [Ins(1,4,5)P3R] ability release Ca2+ stores via type 1 Ins(1,4,5)P3Rs investigated. β-d-Glucopyranosyl 1,3,4-tris-phosphate, with similar phosphate regiochemistry stereochemistry Ins(1,4,5)P3, α-d-glucopyranosyl...
Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply agents of homeostasis other aspects physiology. It seems likely that enzymes interconvert these signals work against prevailing milieu mixed populations competing substrates products. The synthesis inositol pyrophosphates is mediated in plants by two classes ATP-grasp fold kinase: PPIP5 kinases, known as VIH, members tris/tetrakisphosphate kinase (ITPK) family, specifically ITPK1/2. A...