A5070681477- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Augmented Reality Applications
- BIM and Construction Integration
- Gender and Technology in Education
- Quantum chaos and dynamical systems
- Congenital gastrointestinal and neural anomalies
- Proteoglycans and glycosaminoglycans research
- Cancer Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Numerical methods for differential equations
- Stability and Control of Uncertain Systems
- Circular RNAs in diseases
- Bone health and treatments
- Immune Response and Inflammation
- Food Allergy and Anaphylaxis Research
- CRISPR and Genetic Engineering
- Whipple's Disease and Interleukins
- Multiple and Secondary Primary Cancers
- 3D Surveying and Cultural Heritage
- Neonatal Respiratory Health Research
University of California, San Diego
2017-2023
Chang Gung University
2020
Chang Gung Memorial Hospital
2020
National Taiwan Ocean University
2005-2006
Biotechnology Research Institute
2005
National Academies of Sciences, Engineering, and Medicine
2005
National Tsing Hua University
2005
Florida State University
1997
Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to production pathogenic autoantibodies development autoimmunity. Here we show that miR-146a controls by targeting multiple CD40 signaling pathway components in cells; contrast, loss does not alter responses. However, specific deletion both its paralog, miR-146b, increases Tfh cell numbers enhanced reactions....
Follicular helper T (TFH) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged as important players in regulating TFH cell biology. Here, we show that loss of miR-23~27~24 clusters resulted elevated frequencies upon different immune challenges, whereas overexpression this miRNA family led to reduced responses. Mechanistically, coordinately control through targeting a network genes crucial Among them, thymocyte selection-associated HMG-box...
IL-27 controls a diverse range of immune responses in many disease settings. Here, we identify intestinal epithelial cells (IECs) as one the major cellular sources gut-associated tissue. Unlike secreted by innate cells, gut is dispensable for T-bet+ regulatory T cell (T reg cell) differentiation or IL-10 induction. Rather, IEC-derived specifically promotes distinct CD8αα+CD4+ intraepithelial lymphocyte (IEL) population that acquires their functional at epithelium. Loss IECs leads to...
Abstract miR-23∼27∼24 was recently implicated in restricting Th2 immunity, as well the differentiation and function of other effector T cell lineages. Interestingly, miR-24, unlike family members, actually promotes Th1 Th17 responses. In this article, we show that miR-24 drives production IFN-γ IL-17 cells at least part through targeting TCF1, a transcription factor known for its role limiting immunity. Surprisingly, whereas TCF1 previously shown to promote responses inducing GATA3, enforced...
The three-dimensional solution structure of the ligand binding D2 domain fibroblast growth factor receptor (FGFR) is determined using multidimensional NMR techniques. atomic root-mean-square distribution for backbone atoms in structured region 0.64 Å. Secondary structural elements include 11 β-strands arranged antiparallely into two layers β-sheets. characterized by presence a short flexible helix that protrudes out Results size exclusion chromatography and sedimentation velocity experiments...
During thymocyte development, medullary thymic epithelial cells (mTECs) provide appropriate instructive cues in the microenvironment for not only negative selection but also generation of regulatory T (T reg) cells. Here, we identify that miR-155, a microRNA whose expression reg has previously been shown to be crucial their development and homeostasis, contributes (tT cell differentiation by promoting mTEC maturation. Mechanistically, show RANKL stimulation induces miR-155 safeguard medulla...
Regulatory T (Treg) cells are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which Treg control a specific type of immune response given tissue remains unresolved. By simultaneously studying from different origins under systemic autoimmunity, here we show that IL-27 is specifically produced intestinal to regulate Th17 immunity. Selectively increased responses mice with cell-specific ablation led exacerbated inflammation and...
Second primary cancer is prevalent in patients with gastrointestinal (GI) cancer, for which lung the most common and associated high lethality. Image screening was proved to be effective early diagnosis lower mortality. However, trials of screen generally excluded a previous malignancy. The study aimed investigate outcome second factor that improve survival hepato-GI cancer.A total 276 secondary were found among 3723 newly-diagnosed diagnosed Chang Gung Memorial Hospital, between 2010 2014....
Abstract State‐space formulas for reduced‐order H ∞ controllers descriptor systems are given. The approach taken is mainly based on the solutions of two generalized algebraic Riccati equations (GARE), while exploiting structure deflating subspace pencil {E, W ∞}, where an admissible solution to a GARE that counterpart certain ARE (algebraic equation) first developed by Petersen et al. (1991). This has advantage that, proper selection bases space and suitable assumptions, controller may be in...
Abstract T Follicular helper (Tfh) cells are essential for forming geminal centers (GCs) and promoting protective humoral immunity. On the other hand, aberrant Tfh cell responses could also lead to production of autoantibodies development autoimmunity. To date, microRNAs (miRNAs) have emerged as key molecular players in regulating differentiation homeostasis. Here, by using both lost-of-function gain-of-function approaches, we show that loss miR-23~27~24 clusters resulted elevated...
Abstract MicroRNA-155 (miR-155) is a small non-coding RNA highly upregulated in regulatory T (Treg) cells, an immune cell population specialized maintaining immunological tolerance. While the importance of miR-155 conferring Treg competitive fitness has been well established, how regulates development remains unknown. By taking cell-type specific gene targeting approaches, we demonstrate that controls thymic (tTreg) differentiation both cell-intrinsic and -extrinsic manners. Specifically,...
Abstract During thymocyte development, medullary thymic epithelial cells (mTECs) provide appropriate instructive cues in the microenvironment for not only negative selection but also generation of regulatory T (Treg) cells. Here, we identify that miR-155, a microRNA whose expression Treg has previously been shown to be crucial their development and homeostasis, contributes (tTreg) cell differentiation by promoting mTEC maturation. Mechanistically, show RANKL stimulation induces miR-155...