A5101811027- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Biomedical Research and Pathophysiology
- Inflammasome and immune disorders
- Metabolism and Genetic Disorders
- Chemokine receptors and signaling
- Stress Responses and Cortisol
- Dialysis and Renal Disease Management
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Neonatal Health and Biochemistry
- Rheumatoid Arthritis Research and Therapies
- Mitochondrial Function and Pathology
- Renal and Vascular Pathologies
- Drug Transport and Resistance Mechanisms
- Diabetes Treatment and Management
The University of Sydney
2016-2022
Royal North Shore Hospital
2016-2021
Guangdong Provincial Hospital of Traditional Chinese Medicine
2019
Sunnybrook Research Institute
2014
Sunnybrook Hospital
2014
University of Missouri–Kansas City
2007
It is well-known that all progressive chronic kidney disease (CKD) pathologically characterized by tubulointerstitial fibrosis process. Multiple studies have shown the critical role of inflammation and in development CKD. Hence strategies target inflammatory fibrotic signaling pathways may provide promising opportunities to protect against renal fibrosis. Metformin has been used as first-line glucose-lowering agent treat patients with type 2 diabetes mellitus (T2DM) for over 50 years....
Abstract Receptor-interacting protein kinase-3 (RIPK3) is a multifunctional regulator of cell death and inflammation. RIPK3 controls cellular signalling through the formation domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, which recognised to mediate renal fibrogenesis. The role in diabetic kidney disease (DKD) induced fibrosis has not been previously determined. To define action development disease, wild-type (WT), -/- endothelium-derived nitric oxide synthase...
Progressive tubulointerstitial fibrosis has been recognized as a common pathological process that leads to the progression of all chronic kidney disease (CKD). Innovative strategies are needed both prevent and treat CKD. Inflammatory fibrotic signaling pathways play central roles in CKD regardless aetiology. Hence, targeting inflammatory responses holds promise limit renal fibrosis. Metformin most prescribed glucose-lowering medicine worldwide, its potential for many other therapeutic...
Depression is a commonly occurring and persistent sequel of stroke affecting approximately 29% patients. An immunological hypothesis has been put forward, synthesis kynurenine from tryptophan proposed to link inflammatory activity with neurotoxicity neurotransmitter dysfunction. This study assessed the relationship between peripheral blood poststroke depressive symptoms.This was multisite cross-sectional observational cohort patients ischemic stroke. Depressive symptoms were using Center for...
Despite optimal control of hyperglycaemia, hypertension, and dyslipidaemia, the number patients with diabetic nephropathy (DN) continues to grow. Strategies target various signaling pathways prevent DN have been intensively investigated in animal models many proved be promising. However, targeting these once kidney disease is established, remain unsatisfactory. The clinical scenario that diabetes mellitus often present established damage need effective treatments repair reverse damage. In...
Renal fibrosis is common to all forms of progressive kidney disease. However, current therapies limit renal are largely ineffective. Phosphorylation receptor-interacting serine/threonine-protein kinase (RIPK) 3 has been recently suggested be a key regulator the pyrin domain containing (NLRP3) inflammasome, which provides new insights into mechanisms chronic disease (CKD). specific effect RIPK3 on cortical not fully understood. To study function RIPK3, both genetic ablation and...
Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease. quality control primarily mediated by mitochondrial turnover and repair through fission/fusion mitophagy. We have previously shown that blockade calcium-activated potassium channel KCa3.1 ameliorates renal fibrosis. However, mechanistic link between disease not yet known. Transforming growth factor β1 (TGF-β1) plays a central role Recent studies indicate an emerging TGF-β1 regulation function. molecular...
The G protein–coupled CXC chemokine receptor 4 (CXCR4) is a candidate therapeutic target for tissue fibrosis. A fully human single-domain antibody-like scaffold i-body AD-114-PA600 (AD-114) with specific high binding affinity to CXCR4 has been developed. To define its renoprotective role, AD-114 was administrated in mouse model of renal fibrosis induced by folic acid (FA). Increased extracellular matrix (ECM) accumulation, macrophage infiltration, inflammatory response, TGF-β1 expression,...
Purpose: The overall aim of this research work was to evaluate a series dipeptide monoester prodrugs an antiviral agent, ganciclovir (GCV), for oligopeptide transporter-targeted transscleral drug delivery rabbit retina. Methods: permeability and enzymatic hydrolysis GCV were evaluated using freshly excized retinal pigment epithelium (RPE)-choroidsclera (RCS) sclera tissue preparations. Affinity transport mechanism these their translocation across RCS investigated through competitive...
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, causing articular and extra dysfunctions among patients, it could lead to irreversible joint damage or disability if left untreated. Traditional Chinese medicine (TCM) formula, Huayu-Qiangshen-Tongbi (HT) has been found successful in controlling RA TCM clinics. In this study, we conducted systematic analysis of the HT formula with purpose proposing potential mechanism action (MOA) for by using network pharmacological...