A5006358146- vaccines and immunoinformatics approaches
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Cardiovascular Disease and Adiposity
- T-cell and B-cell Immunology
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Renal Diseases and Glomerulopathies
La Trobe University
2018-2022
The G protein–coupled CXC chemokine receptor 4 (CXCR4) is a candidate therapeutic target for tissue fibrosis. A fully human single-domain antibody-like scaffold i-body AD-114-PA600 (AD-114) with specific high binding affinity to CXCR4 has been developed. To define its renoprotective role, AD-114 was administrated in mouse model of renal fibrosis induced by folic acid (FA). Increased extracellular matrix (ECM) accumulation, macrophage infiltration, inflammatory response, TGF-β1 expression,...
Syngeneic murine systems have pre-fixed MHC, making them an imperfect model for investigating the impact of MHC polymorphism on immunodominance in influenza A virus (IAV) infections. To date, there are few studies focusing allelic differences and its even though it is well documented that individual’s HLA plays a significant role determining hierarchy. Here, we describe broad-based CD8+ T cell response healthy individual to IAV infection rather than typical We used systematic antigen screen...