A5101679755- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Musculoskeletal pain and rehabilitation
- Opioid Use Disorder Treatment
- Nausea and vomiting management
- Metabolism and Genetic Disorders
- Stroke Rehabilitation and Recovery
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Vagus Nerve Stimulation Research
- Vestibular and auditory disorders
- Cancer, Hypoxia, and Metabolism
- Pain Mechanisms and Treatments
- Respiratory viral infections research
- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytoestrogen effects and research
- Bacterial Infections and Vaccines
- Pediatric Pain Management Techniques
Shanghai University of Traditional Chinese Medicine
2004-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2016-2024
University of South China
2024
Shengli Oilfield Central Hospital
2023
Weifang People's Hospital
2023
Anhui Medical University
2013-2022
Second Hospital of Anhui Medical University
2013-2022
University of California, San Francisco
2017-2022
First Affiliated Hospital of Anhui Medical University
2022
The microbiota of the aged is variously described as being more or less diverse than that younger cohorts, but comparison groups used and definitions population differ between experiments. differences are often by null hypothesis statistical tests, which notoriously irreproducible when dealing with large multivariate samples. We collected examined gut a cross-sectional cohort 1,000 very healthy Chinese individuals who spanned ages from 3 to over 100 years. analysis 16S rRNA gene sequencing...
Abstract Background Inflammation initiated by damage-associated molecular patterns has been implicated for the cognitive decline associated with surgical trauma and serious illness. We determined whether resolution of inflammation mediates dexmedetomidine-induced reduction pattern–induced decline. Methods Cognitive (assessed trace fear conditioning) was induced high group box 1 protein, a pattern, in mice that also received blockers neural (vagal) humoral inflammation-resolving pathways....
Postoperative cognitive decline (PCD) can affect in excess of 10% surgical patients and be considerably higher with risk factors including advanced age, perioperative infection, metabolic conditions such as obesity insulin resistance. To define underlying pathophysiologic processes, we used animal models a rat model syndrome generated by breeding for trait low aerobic exercise tolerance. After 35 generations, the capacity runner (LCR) rats differ 10-fold their from high (HCR) rats. The LCR...
BACKGROUND Dexmedetomidine is known to be a sedative. Recent studies suggest that administration of dexmedetomidine can prevent postoperative delirium (POD) which has been confirmed as common complication after major surgery. However, its effects in patients undergoing oesophagectomy are scarce. OBJECTIVE To investigate the efficacy and safety reducing POD elderly transthoracic with total intravenous anaesthesia (TIVA). DESIGN A randomised, double-blind, placebo-controlled trial. SETTING...
Abstract Background The prevalence of being bullied traditionally among U.S. high school students is expected to reduce 17.9%, according Healthy People 2020 Initiatives. We examined trends in traditional victimization and cybervictimization with the latest large-scale time-series data United States. Methods analyzed from 2011–2019 national Youth Risk Behavior Survey (YRBS) access students. identified temporal using multivariate logistic regression analyses, accounting for survey design...
Interleukin-6 (IL-6), a pleiotropic cytokine with both degenerative and regenerative properties, is necessary sufficient to provoke perioperative neurocognitive disorders after aseptic trauma in mice. IL-6 initiates its actions binding either membrane-bound receptor α (mIL-6Rα) through classical signalling, or soluble (IL-6R) trans-signalling; signalling pathways require the transducer gp130. We investigated site type of that pertains tibial fracture model disorder.Wild-type genetically...
AIM:To evaluate the effect of hydroxyapatite nanoparticles (Nano HAP) by intravenous injection on inhibition implanted hepatic VX2 tumor growth in rabbits and cell p53/c-Myc protein expression.METHODS: 60 tumor-bearing was randomly divided into five groups.Nano HAP collosol 20 mg/kg, 40 5-FU solutions mg/mL, mixed liquor solution mg/mL Nano mg/kg were infused vein, normal saline conducted as control.The general state, weight, liver function gross volume detected dynamically.The expression...
Morphine has been widely used as rescue treatment for heart attack and failure in humans many decades. Relatively little known about the role of spinal opioid receptors morphine cardioprotection. Recent studies have shown that intrathecal injection can reduce injury caused by ischemia (I)/reperfusion (R) rats. However, molecular cellular mechanisms underlying cardioprotection not determined. Here, we report postconditioning (IMPOC) rescued mean artery pressure (MAP) reduced myocardial I/R....
Gut microbiota plays an important role in the pathogenesis of immune-mediated diseases. However, complex Henoch-Schonlein Purpura (HSP) remains elusive. This study aimed to characterize gut HSP patients and explore potential association between composition phenotypic changes HSP.16SrRNA gene sequencing bioinformatic analyses were performed using total DNA extracted from fecal 34 children with HSP, including 18 primary cases, 16 recurrent 23 healthy children.The diversity indexes showed...
Surgery is accompanied by a systemic inflammatory response that may presage delirium in susceptible individuals. Little known about the trajectory of plasma proinflammatory cytokines and their potential associations with postoperative (POD). The current study longitudinally assessed both pro anti-inflammatory cytokine development POD older surgical patients to investigate individual and/or clusters indicate pathogenic mechanisms.A prospective longitudinal sought enroll >60 years old who were...
Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) are often old and poor in physical fitness. The purpose of this study was to investigate the anesthetic effect different doses alfentanil combined with ciprofol elderly patients (ERCP).In clinical trial, 137 patients, who were candidates for ERCP randomly divided into three groups. Group A given 0.15 μg/kg/min maintenance stage, B 0.25 C 0.35 μg/kg/min. Mean arterial pressure (MAP), heart rate (HR), oxygen saturation...
Background: Osteoporosis is a major health problem that closely related to substantial morbidity, mortality and decline in life quality for the aging population. Although previous studies epidemiological evidence have demonstrated an association between black tea consumption prevention of bone loss, underlying mechanism remains unclear. So, effect extract (BTE) thearubigins (TRs) on osteoporosis rats osteoclast formation vitro were investigated. Methods: In vivo, ovariectomized (OVX) used...
Abstract Background The peak inspiratory pressure (PIP) is crucial in mechanical ventilation with supraglottic airway device (SAD). Pressure-controlled volume-guaranteed (PCV-VG), delivering a preset tidal volume the lowest required pressure, being increasingly used during general anesthesia. In this study, we compared respiratory mechanics and circulatory parameters between volume-controlled (VCV) PCV-VG elderly patients undergoing laparoscopic surgery using laryngeal mask supreme (LMA)....
Count reponses with structural zeros are very common in medical and psychosocial research, especially alcohol HIV the zero-inflated poisson (ZIP) negative binomial (ZINB) models widely used for modeling such outcomes. However, as drinking outcomes days of drinkings counts within a given period, their distributions bounded above by an upper limit (total period) thus inherently follow or (ZIB) distribution, rather than Poisson presence zeros. In this paper, we develop new semiparametric...
To understand epidemiological characteristics of Haemophilus influenzae (Hi) infection in hospitalized children with lower respiratory tract (LRTI) west Sichuan China.The multicenter prospective cross-sectional design was used; four hospitals China were chosen as research field, sputum bacterial culture done and biological typing, PCR identification drug sensitivity test Hi epidemic strains carried out among 0-17y patients LRTI located China.Totally 5 748 cases investigated from Nov. 2013 to...
Abstract Remote intrathecal morphine preconditioning (RMPC) induces cardioprotection via a neural pathway. Intrathecal lidocaine (LID) blocks spinal cord nerve transmission. This study examine whether LID prevents the effects of RMPC. Anesthetized, open chest, male Sprague‐Dawley rats were assigned to one seven treatment groups 3 days after catheter placement. Rats from both RMPC and groups, respectively, received (3 μg/kg) (1%, 10 μL); was administered by three cycles 5‐minute infusions...