A5008150606- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Optical Imaging and Spectroscopy Techniques
- Optical Coherence Tomography Applications
- Photodynamic Therapy Research Studies
- Advanced Fluorescence Microscopy Techniques
- COVID-19 Impact on Reproduction
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Gestational Diabetes Research and Management
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Laser Applications in Dentistry and Medicine
- Global Maternal and Child Health
- Breastfeeding Practices and Influences
- Advanced X-ray and CT Imaging
- Oral Health Pathology and Treatment
- COVID-19 Clinical Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Maternal and Perinatal Health Interventions
- Head and Neck Cancer Studies
- Geriatric Care and Nursing Homes
- Medical Imaging Techniques and Applications
University of California, Davis
2016-2025
UC Davis Health System
2024
Phipps Houses
2015-2021
Université Paris-Sud
2020
Kentuckiana Pulmonary Associates
2020
The University of Texas Health Science Center at San Antonio
2014-2016
Massachusetts General Hospital
2015
The University of Texas System
2015
The University of Texas Health Science Center at Houston
2015
East Carolina University
2015
We demonstrate for the first time application of an endoscopic fluorescence lifetime imaging microscopy (FLIM) system to intraoperative diagnosis glioblastoma multiforme (GBM). The clinically compatible FLIM prototype integrates a gated (down 0.2 ns) intensifier with fiber-bundle (fiber image guide 0.5 mm diameter, 10,000 fibers gradient index lens objective NA, and 4 field view) provide access surgical field. Experiments conducted in three patients undergoing craniotomy tumor resection that...
Since the launch of Fermi satellite, BL Lacertae has been moderately active at gamma-rays and optical frequencies until May 2011, when source started a series strong flares. The exceptional sampling achieved by GLAST-AGILE Support Program (GASP) Whole Earth Blazar Telescope (WEBT) in collaboration with Steward Observatory allows us to perform detailed comparison daily gamma-ray observations Fermi. Discrete correlation analysis between emission reveals time lag 0 +- 1 d, which suggests...
A key mitigation strategy to the COVID-19 pandemic has been development and roll-out of vaccines. However, pregnant lactating people were not included in initial vaccine trials this population is hesitant receive vaccine, despite contrary recommendations from American College Obstetrics Gynecology Centers for Disease Control Prevention. Understanding reasons behind hesitancy vital promote uptake.We surveyed California December 2020 January 2021 (n = 387) describe cognitions decision-making...
A compact clinically compatible fluorescence lifetime imaging microscopy (FLIM) system was designed and built for intraoperative disease diagnosis validated in vivo a hamster oral carcinogenesis model. This apparatus allows the remote image collection via flexible probe consisting of gradient index objective lens fiber bundle. Tissue autofluorescence (337 nm excitation) imaged using an intensified CCD with gate width down to 0.2 ns. We demonstrate significant contrast between tumor...
Abstract A clinically compatible fluorescence lifetime imaging microscopy (FLIM) system was developed. The applied to intraoperative in vivo of head and neck squamous cell carcinoma (HNSCC). endoscopic FLIM prototype integrates a gated (down 0.2 ns) intensifier fiber-bundle endoscope (0.5-mm-diameter, 10,000 fibers with gradient index lens objective 0.5 NA, 4-mm field view), which provides access the surgical field. Tissue autofluorescence induced by pulsed laser (337 nm, 700 ps pulse width)...
Abstract Due to loss of tactile feedback the assessment tumor margins during robotic surgery is based only on visual inspection, which neither significantly sensitive nor specific. Here we demonstrate time-resolved fluorescence spectroscopy (TRFS) as a novel technique complement inspection oral cancers transoral (TORS) in real-time and without need for exogenous contrast agents. TRFS enables identification cancerous tissue by its distinct autofluorescence signature that associated with...
Tumor-free surgical margins are critical in breast-conserving surgery. In up to 38% of the cases, however, patients undergo a second surgery since malignant cells found at excised resection specimen. Thus, advanced imaging tools needed ensure clear time The objective this study was evaluate random forest classifier that makes use parameters derived from point-scanning label-free fluorescence lifetime (FLIm) measurements breast specimens as means diagnose tumor and enable an intuitive...
Abstract Background It is unknown how the novel Coronavirus SARS‐CoV‐2, cause of current acute respiratory illness COVID‐19 pandemic that has infected millions people, affects people with intellectual and developmental disability (IDD). The aim this study to describe individuals IDD have been affected in first 100 days pandemic. Methods Shortly after case was reported USA, our organisation, which provides continuous support for over 11 000 IDD, assembled an outbreak committee composed senior...
Existing clinical intravascular imaging modalities are not capable of accurate detection critical plaque pathophysiology in the coronary arteries. This study reports first catheter combining ultrasound (IVUS) with multispectral fluorescence lifetime (FLIm) that enables label-free simultaneous assessment morphological and biochemical features vessels vivo. A 3.7 Fr a fiber-optic channel was constructed based on 40 MHz IVUS catheter. The ability to safely acquire co-registered FLIm-IVUS data...
Re-excision rates for breast cancer lumpectomy procedures are currently nearly 25% due to surgeons relying on inaccurate or incomplete methods of evaluating specimen margins. The objective this study was determine if could be automatically detected in specimens from mastectomy and by a classification algorithm that incorporated parameters derived fluorescence lifetime imaging (FLIm). This generated database co-registered histologic sections FLIm data (N = 20) support vector machine (SVM)...
Introduction: Hypertensive disorders of pregnancy (HDPs) are rising in the United States, leading to increased maternal mortality, future complications, and cardiovascular disease (CVD) risk factors like hypertension diabetes. Studies suggest that HDPs have different etiologies than non-pregnancy hypertensive disorders, it is unclear whether behavioral lifestyle for CVD general similar HDPs. Hypothesis: We hypothesized women with lower levels physical activity early would a higher Methods:...
Background: Postpartum weight retention (PPWR), even among women with normal prepregnancy BMI, is linked to worsening cardiovascular (CV) risk factors as soon 5 years post-delivery, increasing for midlife CV disease. Depression or anxiety at any point during pregnancy may contribute the development of postpartum, including PPWR. Little known about impact mood in early on PPWR, especially individuals overweight/obesity. This a significant gap given treatability disorders. Hypothesis: Women...
Simultaneous time-and wavelength-resolved fluorescence spectroscopy (STWRFS) was developed and tested for the dynamic characterization of atherosclerotic tissue ex vivo arterial vessels in vivo.Autofluorescence, induced by a 337 nm, 700 ps pulsed laser, split to three wavelength sub-bands using dichroic filters, with each sub-band coupled into different length optical fiber temporal separation.STWRFS allows fast recording/analysis (few microseconds) timeresolved emission these rapid...
This study aimed to systematically investigate whether plaque autofluorescence properties assessed with intravascular fluorescence lifetime imaging (FLIm) can provide qualitative and quantitative information about intimal composition improve the characterization of atherosclerosis lesions. Despite advances in cardiovascular diagnostics, analytic tools technologies currently available have limited capabilities for evaluating situ biochemical changes associated luminal surface features....
Clinical trials worldwide were disrupted when the COVID-19 pandemic began in early 2020. Most intervention moved to some form of remote implementation due restrictions on in-person research activities. Although proportion is growing, they remain vast minority studies part few successful examples. Our team transitioned Goals for Reaching Optimal Wellness (GROWell), an NIH-funded (R01NR017659) randomized control trial (RCT; ClinicalTrials.gov identifier NCT04449432) originally designed as a...
Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding sudden death in patients with high risk rupture.We report on multimodality imaging ex-vivo human carotid samples using a system that integrates fluorescence lifetime (FLIM), ultrasonic backscatter microscopy (UBM), and photoacoustic (PAI).Biochemical composition is differentiated temporal resolution sensitivity at the surface by FLIM subsystem.3D microanatomy whole reconstructed UBM.Functional...
This study investigates the ability of a flexible fiberoptic-based fluorescence lifetime imaging microscopy (FLIM) technique to resolve biochemical features in plaque fibrotic cap associated with instability and based solely on decay characteristics. Autofluorescence atherosclerotic human aorta (11 autopsy samples) was measured at 48 locations through two filters, F377: 377/50 F460: 460/60 nm (center wavelength/bandwidth). The dynamic described by average (τ) four Laguerre coefficients...
We present a novel fiber-based imaging platform that allows simultaneous fluorescence lifetime (FLIm) and optical coherence tomography (OCT) using double-clad fiber. This acquires co-registered images showing structural compositional contrast in unlabeled biological samples by scanning the fiber tip across sample surface. In this Letter, we report characterization of each modality show examples FLIm OCT acquired from lemon segment section human coronary artery. The close comparison between...
During public health emergencies, including the COVID-19 pandemic, access to adequate healthcare is crucial for providing and wellbeing of families. Pregnant postpartum people are a particularly vulnerable subgroup consider when studying access. Not only perinatal likely at higher risk illness, mortality, morbidity from infection, they also negative outcomes due delayed or inadequate routine care.We surveyed 820 pregnant in California over two waves pandemic: (1) 'non-surge' wave (June 2020,...
The aim of this study was to validate novel imaging technology for simultaneous morphological and biochemical endogenous optical coronary atherosclerotic plaque. Optical coherence tomography (OCT) generates high-resolution 3D images plaque morphology fluorescence lifetime microscopy (FLIM) characterizes composition. Both modalities rely on plaque's intrinsic characteristics, making contrast agents unnecessary. A multimodal OCT/FLIM system utilized generate luminal maps superimposed (7 µm...
To investigate the benefit of using time-resolved, laser-induced fluorescence spectroscopy for diagnosing malignant and premalignant lesions oral cavity.
Abstract Background and Objective This study describes a novel fluorescence lifetime imaging (FLIM) classification method to determine the ratio of collagen lipid content in fibrous cap atherosclerotic plaques. Additionally, an analytical process assess risk plaque rupture based on this is proposed. Collagen has been shown be important parameter evaluate structural integrity cap. FLIM other time‐resolved techniques have recently applied atherosclerosis ability biochemical composition. Study...
An important step in establishing the diagnostic potential for emerging optical imaging techniques is accurate registration between data and corresponding tissue histopathology typically used as gold standard clinical diagnostics. We present a method to precisely register acquired with point-scanning spectroscopic technique from fresh surgical specimen blocks histological sections. Using visible aiming beam augment multispectral time-resolved fluorescence spectroscopy on video images, we...
Residents of congregate care settings have been severely impacted by the current Coronavirus disease 2019 (COVID-19) pandemic. In this report, we describe methods our home-based primary practice has developed to mitigate spread COVID-19 in assisted living facilities (ALFs) and present an initial evaluation innovation. Shortly after first case was reported United States, organization assembled outbreak committee, designed support 1794 ALF residents 101 communities which they reside. The...