A5043279240- Respiratory viral infections research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Vector-Borne Animal Diseases
- Neonatal Respiratory Health Research
- Hepatitis B Virus Studies
- Genetics and Neurodevelopmental Disorders
- Influenza Virus Research Studies
- Systemic Lupus Erythematosus Research
- Animal Virus Infections Studies
University of Leeds
2018-2024
Institute of Structural and Molecular Biology
2019
Human respiratory syncytial virus (HRSV) is a leading cause of illness, particularly in the young, elderly, and immunocompromised, has also been linked to development asthma. HRSV replication depends on P L, whereas transcription requires M2-1. M2-1 interacts with RNA at overlapping binding sites; while these interactions are necessary for transcriptional activity, mechanism action unclear. To better understand transcription, we solved crystal structure complex minimal interaction domain,...
Chikungunya virus (CHIKV) is a re-emerging, pathogenic alphavirus that transmitted to humans by Aedes spp. mosquitoes—causing fever and debilitating joint pain, with frequent long-term health implications high morbidity. The CHIKV lifecycle poorly understood specific antiviral therapeutics or vaccines are lacking. In this study, we investigated the role of host-cell chloride (Cl-) channels on replication.We demonstrate pharmacological Cl- channel inhibitors significantly inhibit replication...
Introduction Human respiratory syncytial virus (HRSV) is a common cause of tract infections (RTIs) globally and one the most fatal infectious diseases for infants in developing countries. Of those infected, 25%–40% aged ≤1 year develop severe lower RTIs leading to pneumonia bronchiolitis, with ~10% requiring hospitalisation. Evidence also suggests that HRSV infection early life major adult asthma. There no vaccine, only clinically approved treatment immunoprophylaxis expensive moderately...
Lymphocytic choriomeningitis virus (LCMV) is a bisegmented negative-sense RNA classified within the
Nairoviruses are tick-borne enveloped RNA viruses that include several pathogens responsible for fatal disease in humans and animals. Here, we analyzed host genes involved trafficking networks to examine their involvement nairovirus replication. We revealed important roles express multiple components of the COPI complex, which regulates transport Golgi apparatus-resident cargos. influenced at least two stages replication cycle: an early stage prior including gene expression also a later...
Abstract Lymphocytic choriomeningitis virus (LCMV) is a bisegmented negative-sense RNA classified within the Arenaviridae family of Bunyavirales order. LCMV associated with fatal disease in immunocompromised populations, and as prototypical arenavirus, acts model for many serious human pathogens family. Here, we examined dependence multiplication on cellular trafficking components using recombinant expressing enhanced green fluorescent protein conjunction curated siRNA library. The screen...
Chikungunya virus (CHIKV) causes fever and debilitating joint pain, with frequent long-term health implications cumulating fatalities worldwide. There are no specific antivirals vaccines, therefore understanding CHIKV replication is essential to establish treatments preventative measures. Cellular ion channels druggable targets known facilitate of RNA viruses. To determine if the activities cellular chloride (Cl--channels) required during replication, we applied broad-ranging inhibitors...
Ion channels are a diverse class of transmembrane proteins, which selectively allow ions across cellular membranes, influencing multitude processes. Modulation these by viruses is emerging as an important host-pathogen interaction, and has been demonstrated to regulate critical stages the virus multiplication cycle including entry, replication egress. Human respiratory syncytial (HRSV) causes severe tract infections (RTIs) globally one most lethal pathogens for infants in developing...