A5034962867- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Molecular Junctions and Nanostructures
- Organometallic Complex Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Computational Drug Discovery Methods
- Antibiotic Resistance in Bacteria
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Magnetism in coordination complexes
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Chemical Synthesis and Analysis
- Machine Learning in Materials Science
- Bacterial Genetics and Biotechnology
- Metal-Organic Frameworks: Synthesis and Applications
University of Łódź
2013-2024
Zero to Three
2021
Faculty (United Kingdom)
2015-2018
Abstract The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has called for an urgent need dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that used screening drug discovery campaigns, however, there is growing evidence their role medicinal chemistry. Based on previous results, we have selected more than 100 structurally diverse metal profiling as inhibitors two relevant SARS‐CoV‐2 replication mechanisms,...
A new family of metallocene–uracil conjugates, including [3-(N1-uracilyl)-1-(ferrocenyl)]propene (2c), [3-(N1-thyminyl)-1-(ferrocenyl)]propene (3c), [3-(N1-(5-fluorouracilyl))-1-(ferrocenyl)]propene (4c), and [3-(N1-uracilyl)-1-(ruthenocenyl)]propene (5c), was obtained in three steps from (3-chloropropionyl)ferrocene (3-chloropropionyl)ruthenocene, respectively. The complexes 2c–5c their intermediates 2a–5a 2b–5b were characterized by NMR infrared spectroscopy, mass spectrometry, elemental...
A series of six novel metallocenyl-7-ADCA (metallocenyl = ferrocenyl or ruthenocenyl; 7-ADCA 7-aminodesacetoxycephalosporanic acid) conjugates were synthesized and their antibacterial properties evaluated by biochemical microbiological assays. The ruthenocene derivatives showed a higher level inhibition DD-carboxypeptidase 64-575, Penicillin Binding Protein (PBP), than the ferrocene reference compound penicillin G. X-ray crystallographic analysis revealed covalent acyl-enzyme complex...
Crystal structure of β-lactam product complex with CTX-M-14 E166A mutant sheds light on β-lactamase catalysis and ruthenocene binding by proteins.
Luminescent <italic>fac</italic>-[Re(CO)<sub>3</sub>(phen)(aspirin)]: insights into <italic>in vitro</italic> anticancer activity and confocal microscopy imaging in HeLa cells.
Two new neutral fac-[Re(CO)₃(phen)L] compounds (1,2), with phen = 1,10-phenanthroline and L O₂C(CH₂)₅CH₃ or O₂C(CH₂)₄C≡CH, were synthetized in one-pot procedures from fac-[Re(CO)₃(phen)Cl] the corresponding carboxylic acids, fully characterized by IR UV-Vis absorption spectroscopy, ¹H- 13C-NMR, mass spectrometry X-ray crystallography. The compounds, which display orange luminescence, used as probes for living cancer HeLa cell staining. Confocal microscopy revealed accumulation of both dyes...
The first-in-class luminescent dinucleoside phosphate analogs with a [Re2(μ-Cl)2(CO)6(μ-pyridazine)] "click" linker as replacement for the natural group are reported together synthesis of adenosine and thymidine derivatives having entity attached to positions 5' 3', respectively. These compounds were synthesized by applying inverse-electron-demand Diels-Alder copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reactions in three or four steps. obtained exhibited orange emission (λPL ≈...
The synthesis of two new donor–acceptor ferrocenyl derivatives with Meldrum's acid based nonplanar acceptor substituents is presented. Both compounds are obtained in high yields a simple reaction protocol under mild conditions using either 1-acetyl- or 1,1′-diacetylferrocene and acid. products have been characterized spectroscopically, by single-crystal X-ray structure analysis, electrochemical UV/vis/IR spectroelectrochemical measurements, (TD)-DFT calculations. measurements disclose that...
Abstract The enantioselective synthesis and electrochemistry of the first ferrocenyl GNA nucleosides is reported. These compounds were obtained by a Sharpless asymmetric dihydroxylation reaction [3‐( N 1‐thyminyl)‐1‐(ferrocenyl)]propene as S , R enantiomers in about 70 % yield with enantiomeric excesses >99 71 %, respectively. absolute configurations chiral carbon atoms assigned single‐crystal X‐ray diffraction analysis methyl derivatives solid state. also studied circular dichroism (CD)...
Bioimaging techniques that allow the visualization of ferrocene in living cells do not exist. This work addresses this challenging problem, and a new indirect approach for bioimaging ferrocenyl compounds fixed is proposed. It based on structural similarity metallocenyl (ferrocenyl ruthenocenyl) groups to their metal‐free [2.2]paracyclophanyl congeners. Three adequately designed were obtained. They share 5‐(1‐ethynylpyrenyl)uracil group as common motif differ three‐dimensional aromatic...
The β‐lactam antibiotics inhibit penicillin‐binding proteins ( PBP s) by forming a stable, covalent, acyl‐enzyme complex. During the evolution from s to Class A β‐lactamases, β‐lactamases acquired Glu166 activate catalytic water and cleave bond. Here we present three product complex crystal structures of CTX ‐M‐14 β‐lactamase with ruthenocene‐conjugated penicillin—a 0.85 Å resolution structure E166A mutant complexed penilloate product, 1.30 same penicilloate 1.18 S70G epimer—shedding light...
Abstract In this paper, we report the Yb(OTf) 3 ‐mediated etherification reaction that allowed obtaining R , and S isomers of ferrocenyl glycol nucleic acid (Fc‐GNA) nucleosides from their corresponding stereo‐defined ( ) precursor. The absolute configuration chiral carbon atoms in one Fc‐nucleoside was assigned by single‐crystal X‐ray diffraction. Density functional theory calculations showed stereochemical outcome can be explained an exo attack ethylene on pro‐ ‐ or ‐configured...