A5004601665- Nail Diseases and Treatments
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Plant Pathogens and Fungal Diseases
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Genomics and Phylogenetic Studies
- Click Chemistry and Applications
- Toxoplasma gondii Research Studies
- Radiopharmaceutical Chemistry and Applications
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Community Ecology and Physiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antifungal resistance and susceptibility
- Boron Compounds in Chemistry
- Bioactive Compounds and Antitumor Agents
- Probiotics and Fermented Foods
- Fungal Infections and Studies
- Bacterial Genetics and Biotechnology
- Enterobacteriaceae and Cronobacter Research
- Metal complexes synthesis and properties
- Gut microbiota and health
- Glycosylation and Glycoproteins Research
- Mycobacterium research and diagnosis
University of Łódź
2015-2025
Czech Academy of Sciences, Institute of Microbiology
2012-2017
Institute of Medical Biology
2017
Institute for Medical Biology
2007
Polish Academy of Sciences
2007
University of Alabama at Birmingham
1998
In bacteria, DNA supercoil movement is restricted to subchromosomal regions or ‘domains.’ To elucidate the nature of domain boundaries, we analysed reaction kinetics for γδ site‐specific resolution in six chromosomal intervals ranging size from 14 90 kb. stationary cultures Salmonella typhimurium , were rapid both short and long intervals, suggesting that random barriers occur with a 30% probability at approximately 80 kb along DNA. test biochemical barriers, genetic screen was used look...
The genus Proteus belongs to the Enterobacteriaceae family, where it is placed in tribe Proteeae, together with genera Morganella and Providencia. Currently, consists of five species: P. mirabilis, vulgaris, penneri, hauseri myxofaciens, as well three unnamed genomospecies. most defining characteristic bacteria a swarming phenomenon, multicellular differentiation process short rods elongated swarmer cells. It allows population migrate on solid surface. inhabit environment are also present...
Organometallic ciprofloxacin conjugates were synthesized and two mechanisms of antimicrobial activity demonstrated. The first mechanism involves the inhibition type IIA topoisomerases second ROS generation in bacterial cells.
Formation of infectious urinary calculi is the most common complication accompanying tract infections by members genus Proteus. The major factor involved in stone formation urease produced these bacteria, which causes local supersaturation and crystallization magnesium calcium phosphates as carbonate apatite [Ca(10)(PO(4))(6).CO(3)] struvite (MgNH(4)PO(4).6H(2)O), respectively. This effect may also be enhanced bacterial polysaccharides. Macromolecules such kind contain negatively charged...
Luminescent <italic>fac</italic>-[Re(CO)<sub>3</sub>(phen)(aspirin)]: insights into <italic>in vitro</italic> anticancer activity and confocal microscopy imaging in HeLa cells.
A series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation host cell cytotoxicity. At non-toxic concentrations cells all studied compounds displayed excellent anti-parasitic effects when compared to sulfadiazine, indicating high selectivity their anti-T. activity. The differences bioactivity investigated by DFT calculations suggest that inhibitory activity...
We have synthesized and examined the antibacterial activity, toxicity affinity towards bacterial type II topoisomerases of a series 1,2,4-triazole-ciprofloxacin hybrids. A number these compounds displayed enhanced activity against Gram-positive Gram-negative bacteria when compared to ciprofloxacin. The toxic concentrations obtained derivatives, evaluated on HEK-293 cells using MTT assay, were much higher than required produce effect. Finally, results enzymatic studies showed that analyzed...
We synthesized a series of novel 3-carboranyl-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, using click chemistry, reductive amination amidation reactions investigated their in vitro effects on cytotoxicity, cell death, cycle, the production reactive oxygen species HepG2 cancer line. The analyses showed that modified naphthalic anhydrides naphthalimides bearing ortho- or meta-carboranes exhibited diversified activity. Naphthalimides were more cytotoxic than anhydrides, with...
Introduction Endometrial cancer (EC) is a significant gynecological malignancy with increasing incidence worldwide. Emerging evidence highlights the role of uterine microbiome in pathogenesis EC. This study aims to characterize EC patients and identify potential microbial biomarkers, focus on Anaerococcus as differentiating taxon. Methods The endocervical canal swabs from (n=16) non-cancerous (EM, n=13) were collected. V3-V4 region 16S rRNA gene was sequenced using Illumina platform....
In order to identify the source of infections caused by dermatophytes, as well pathogen transmission pathway, there is a need determine methods that allow detailed genetic differentiation strains within dermatophyte genera. this work, PCR melting profile (PCR-MP) technique based on ligation adaptors and difference in temperatures DNA restriction fragments was used for first time intraspecies genotyping dermatophytes. Clinical isolates reference dermatophytes isolated from skin, scalp,...
Abstract Synthesis of acridine derivatives that act as DNA‐targeting anticancer agents is an evolving field and has resulted in the introduction several drugs into clinical trials. Carboranes can be importance designing biologically active compounds due to their specific properties. Therefore, a series novel analogs modified with carborane clusters were synthesized. The DNA‐binding ability these was evaluated on calf thymus DNA (ct‐DNA). Results analyses showed 9‐[(1,7‐dicarba‐ closo...
In the present article, we describe inhibitory potency of nine thiosemicarbazide derivatives against bacterial type IIA topoisomerases, their antibacterial profile and molecular modelling evaluation. We found that one tested compounds, compound 7, significantly inhibits activity Staphylococcus aureus DNA gyrase with an IC(50) below 15 μM. Besides, this displays on reference Staphylococuss spp. Enterococcus faecalis strains as well clinical S. isolates at non-cytotoxic concentrations in...
In the present paper, we report synthesis and evaluation of in vitro antimicrobial activities aziridine-thiourea derivatives. A series aziridines reaction with isocyanates isothiocyanates to obtain urea thiourea derivatives were used. The structures all new products confirmed based on spectroscopic data (1H-NMR, 13C-NMR, HR-MS). These compounds screened for their activity against a panel Gram-positive Gram-negative strains bacteria. Six tested appeared be promising agents reference...
The synthesis of carborane-1,8-naphthalimide conjugates and evaluation their DNA-binding ability anticancer activity were performed. A series 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide pinafide analogs, synthesised via amidation reductive amination reactions, calf thymus DNA (ct-DNA)-binding properties investigated using circular dichroism, UV–vis spectroscopy, thermal denaturation. Results showed that 34–37 interacted very strongly with ct-DNA (ΔTm = 10.00–13.00 °C),...